DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3097 and AGBL2

DIOPT Version :9

Sequence 1:	NP_572259.1	Gene:	CG3097 / 31503	FlyBaseID:	FBgn0029804	Length:	445	Species:	Drosophila melanogaster
Sequence 2:	NP_079059.2	Gene:	AGBL2 / 79841	HGNCID:	26296	Length:	902	Species:	Homo sapiens

Alignment Length:	315	Identity:	66/315 - (20%)
Similarity:	104/315 - (33%)	Gaps:	113/315 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 IRTKFPNIVRLYTIGQTAEGRDLKVLRI---SENPRE---NKKVWIDGGIHARE----WISPATV 215
            |:::|   .:|.|:.::..|..:.:|.|   |:.|:|   .|.|.:...:|..|    |:....:
Human   415 IQSQF---CKLQTLCRSLAGNTVYLLTITNPSQTPQEAAAKKAVVLSARVHPGESNGSWVMKGFL 476

  Fly   216 TFIL-----YQLMSDWENQPAHIRGLTWYIMPVMNPDGYEYSRTTNRLWRKNRSPSRRAQCSGVD 275
            .|||     .||:.|.         ..:.::|::||||....             :.|...:|.|
Human   477 DFILSNSPDAQLLRDI---------FVFKVLPMLNPDGVIVG-------------NYRCSLAGRD 519

  Fly   276 LNRNFDIGWNGYGSSTNPCSDTYRGSAP--ASERETRAVAEFLA---------------KRKY-- 321
            |||::    ......:.||....|....  ..|||.....:|..               .|||
Human   520 LNRHY----KTILKESFPCIWYTRNMIKRLLEEREVLLYCDFHGHSRKNNIFLYGCNNNNRKYWL 580

  Fly   322 -----------NLESYLTFHSYGQMIVYPWAYKAVKVKDAS---VLQRVSSLAAERILQKTGTSY 372
                       |.....:|||..        :|..|.|:.:   |:.|:..|          .||
Human   581 HERVFPLMLCKNAPDKFSFHSCN--------FKVQKCKEGTGRVVMWRMGIL----------NSY 627

  Fly   373 RAAVTHEVLGIAGGGSDDWSRAALGVKYVYTIELRDRGAYGFVLPPRFIKDTALE 427
            ....|.       |||      .||.|......:.|..:.|:     .:.||.|:
Human   628 TMESTF-------GGS------TLGNKRDTHFTIEDLKSLGY-----HVCDTLLD 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3097	NP_572259.1	Propep_M14	64..118	CDD:280416
CG3097	NP_572259.1	M14_CP_A-B_like	148..439	CDD:199844	66/315 (21%)
AGBL2	NP_079059.2	GVQW	105..>120	CDD:290611
		M14_AGBL2-3_like	407..666	CDD:133117	66/315 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	746..770
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	796..879
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900