DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4078 and AT1G79950

DIOPT Version :9

Sequence 1:	NP_001259262.1	Gene:	CG4078 / 31497	FlyBaseID:	FBgn0029798	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_178113.3	Gene:	AT1G79950 / 844335	AraportID:	AT1G79950	Length:	1040	Species:	Arabidopsis thaliana

Alignment Length:	1069	Identity:	344/1069 - (32%)
Similarity:	539/1069 - (50%)	Gaps:	181/1069 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPESLIAGIPVHFPFEPYPVQRAYMEKVIHCLRDGTNGVLESPTGTGKTLSLLCSSLAWIRTRQS 65
            ||...|.||.|.||||.|..|..||::||..|::..:.:|||||||||||.|||::|||.::..|
plant    46 MPNYSIRGINVEFPFEAYQSQIIYMDRVIESLQNKCHALLESPTGTGKTLCLLCATLAWRKSLGS 110

  Fly    66 EHQKQMVKMEKADFSGLGGGAPGGDLSELAKTMGRANNWGVPKVIYASRTHSQLTQAMRELKRTA 130
            ...::..|         ....|..|..|.....|.......|.::|||||||||.|.::||||::
plant   111 FSTRKDRK---------NSAIPWSDSDEPLSQSGGGGGGAFPTIVYASRTHSQLRQVIKELKRSS 166

  Fly   131 YANMRSVVLGSRDQLCIHPEVMREQGNSNKTN----MCKLRVHSKTCSFQMRVESRKDHPDLRGP 191
            | ..:.||||||:|||::.||...:|.: .||    :||.|...:...|....:..|.:|.: |.
plant   167 Y-RPKMVVLGSREQLCVNEEVNSLRGKA-LTNACQYLCKKRGKRQCNHFNRLPDYLKHNPHI-GD 228

  Fly   192 TIMDIEDLVKVGQRLKICPYFASRELVPQADITFMPYNYLLDPKARKANKIELGNTIVILDEAHN 256
            ..:||||||.:|:....|||:.:|||....||.|.|||||:....||..|:...|:::|.|||||
plant   229 EPVDIEDLVNIGKDSGPCPYYITRELHKDVDIIFAPYNYLISNGYRKFLKVNWTNSVLIFDEAHN 293

  Fly   257 IEKICEESASVQIKSSDVAMAIEDVTHIMQVFASGESQDMAGD---EPKDFTLDDLTLLKEMLLE 318
            :|.:|.:|||..:.|..::..|.:....:|:.|:  .:|...|   .|::|     .:||.:||:
plant   294 LESLCADSASFDLPSVLLSACISEAQECVQLAAA--RRDSLNDVSINPENF-----AILKGLLLK 351

  Fly   319 LEKAIDAIVVDNAVDGTTFPASMMYELLGKANFTYGNVATIVSLLDKLVQYLLVASQQMSIRKGG 383
            |::.|..:.:....:|.|.|...:||:|...|.|:.....::..:::...:|....|:.:...|.
plant   352 LQELISKVPIPKRDEGFTKPGPYIYEMLKSLNITHETAPKLIGTVEEAAVFLEEEKQRTATNAGS 416

  Fly   384 TFTLLSDLLTIVF----ANKEDVMSKVYASFKVHVLVEESKQGHGKQQGAKQQGGWLGKGTIAAA 444
            ...:::|:|.::|    :|..||       ::|||            |..:|....:.||
plant   417 KLEIIADMLKLIFRENGSNHADV-------YRVHV------------QELEQNSTDVMKG----- 457

  Fly   445 TGLSKVAKIINFWCFNPGFGMEQLLNTQVRSVILTSGTLAPLKPLIAELAIPVAQHLENPHIVDQ 509
                ||::.:::|||:||..|..:....|.|:|||||||:|:..|..||.:.....|||||::..
plant   458 ----KVSRTLSWWCFSPGITMLDIAQKGVGSIILTSGTLSPMDSLAQELKLDFPIRLENPHVISS 518

  Fly   510 SQVYVKIIGTGPDRQQLISNYANRDNPKYISSLGQTILNVARIVPDGLLVFFPSYPMLNKCVDAW 574
            :|::..::.|||....|.|:|.|||.|:|...||..|:|.:|:||:|||:|||||.:::.|:..|
plant   519 NQLWAGVVSTGPSGYVLNSSYRNRDVPEYKQELGNAIVNFSRVVPEGLLIFFPSYYLMDSCITFW 583

  Fly   575 Q------ASGLWADI-SCKKPIFLEPRSKDQFTSTMEEFYQAIRD--SKGAVFMAVCRGKVSEGL 630
            :      :..:|..| ..|||: :||:....|.:.|.:|.:.::|  :.|.||.|||||||||||
plant   584 KNGCYRNSMTVWERICKLKKPV-IEPKDSSLFPAAMRDFSEKLQDRATSGVVFFAVCRGKVSEGL 647

  Fly   631 DFADRNGRAVIITGLPFPPLKDPKVILKRRYLEAN------RTRENQLLSGQEWYNLDATRAVNQ 689
            ||||..||||:|||||:..:.||:|.|||.:|:..      :...:.||||..||:.:|.|||||
plant   648 DFADGAGRAVVITGLPYARVTDPRVKLKREFLDEQSQLADVKLPRSTLLSGSMWYSQEAARAVNQ 712

  Fly   690 AIGRVIRHRNDYGAILLCDSRFKDASQVQQLSKWIRGHLGDRPQC-SPFGPIVRELRQFFKNAEA 753
            |||||||||:|||||:.||.||:..||..::|.|||.::    :| |.:|.::.:|.:||:...:
plant   713 AIGRVIRHRHDYGAIIFCDDRFEQPSQQSKISLWIRPNV----KCYSRYGEVISDLARFFRTERS 773

  Fly   754 NM--KLPDERE-----TDSPLETVCKTEDEPLAAIPKVKREPGSNATFKSANESAIKVEMANSIK 811
            |.  :|..|:|     |..|:|::   ||.|..|.        .|:..|  |....:.|::. ::
plant   774 NFPARLVTEQENNIVSTLLPVESI---EDNPTPAF--------GNSNLK--NVGVAQNELSR-LE 824

  Fly   812 TWTPADYAS--------------------------AAGHKLGGAAPNAMDFMSRLDSNVSSIDFN 850
            .:.||:.||                          ..|..:.|.:......:...|...:.::..
plant   825 AFPPANRASPLERDGNNVKRNGLTILKHTGKIPRIVKGDVMQGCSSRKAKLVELSDDEETPVERR 889

  Fly   851 C--------------CTDSKSGSS------GLVKIHKRERSSPTAPESSSQVTKKRYKLVENIKV 895
            |              |......||      ||.|..|...|..:|  |||.:|.|
plant   890 CEVVDLESDNCETQTCVTEVLASSTCLNTMGLKKKRKVPESQGSA--SSSVLTAK---------- 942

  Fly   896 EPSSSQAKEAPEERAAFLRELRSLVTQDQFRRFGKALLEYKNGTYESFQAL----------MAIL 950
            .......|||  ..:|||.:::..:..:::::|    :.|       .|||          |..:
plant   943 GNGGGDKKEA--SASAFLSQVKEKLNTEEYKKF----IGY-------MQALKKKEIKLANVMQSI 994

  Fly   951 LDVLSAPKVRYMLVGMRKYLKNEHKDEFD 979
            :.:....:..::|:|.:.::..:::..::
plant   995 VQLFCGSERDHLLMGFKDFVPVKYRPAYE 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4078	NP_001259262.1	rad3	10..742	CDD:273169	285/758 (38%)
		DEAD_2	111..274	CDD:284209	73/166 (44%)
		Helicase_C_2	546..725	CDD:290046	94/193 (49%)
		HN_RTEL1	896..985	CDD:259826	14/94 (15%)
AT1G79950	NP_178113.3	rad3	56..762	CDD:273169	285/757 (38%)
AT1G79950	NP_178113.3	HN_RTEL1	928..1032	CDD:259826	21/121 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	187	1.000	Domainoid score	I976
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H13168
Inparanoid	1	1.050	500	1.000	Inparanoid score	I317
OMA	1	1.010	-	-		QHG53562
OrthoDB	1	1.010	-	-		D186062at2759
OrthoFinder	1	1.000	-	-		FOG0006111
OrthoInspector	1	1.000	-	-		oto3453
orthoMCL	1	0.900	-	-		OOG6_102317
Panther	1	1.100	-	-	LDO	PTHR11472
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4406
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840