Protein Alignment CG4078 and BRIP1

DIOPT Version :9

• Sequence 1: NP_001259262.1
• Gene: CG4078 / 31497
• FlyBaseID: FBgn0029798
• Length: 985
• Species: Drosophila melanogaster
• Sequence 2: XP_011523634.1
• Gene: BRIP1 / 83990
• HGNCID: 20473
• Length: 1269
• Species: Homo sapiens
• Alignment Length: 1225
• Identity: 315/1225 - (25%)
• Similarity: 490/1225 - (40%)
• Gaps: 386/1225 - (31%)

  Fly     3 ESLIAGIPVHFPFEPYPVQRAYMEKVIHCLRDGTNGVLESPTGTGKTLSLLCSSLAWIR------ 61
            |..|.|:.::||::.||.|.|.|..::..|....:.:||||||:||:|:||||:|||.:
Human     7 EYTIGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSALAWQQSLSGKP 71

  Fly    62 -----------------------------------------TRQSEH------------------ 67
                                                     |..||.
Human    72 ADEGVSEKAEVQLSCCCACHSKDFTNNDMNQGTSRHFNYPSTPPSERNGTSSTCQDSPEKTTLAA 136

  Fly    68 ------QKQMVKMEKADFS--------------------------GLGGGAPGGDLSELAKTMGR 100
                  |..:.:.|..||.                          .|......|...:|...:.:
Human   137 KLSAKKQASIYRDENDDFQVEKKRIRPLETTQQIRKRHCFGTEVHNLDAKVDSGKTVKLNSPLEK 201

  Fly   101 ANNWG------------------------------------VPKVIYASRTHSQLTQAMRELKRT 129
            .|::.                                    :||:.:.:|||.|:.|..|||:||
Human   202 INSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRT 266

  Fly   130 AYANMRSVVLGSRDQLCIHPEVMREQGNSNKTNMCKLRV---HSKTCSFQMRVESRKDHPDLRGP 191
            ||:.:...:|.|||..|:||||:   ||.|:...|...:   :.|:|.|...|....|...|:..
Human   267 AYSGVPMTILSSRDHTCVHPEVV---GNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTF 328

  Fly   192 TIM----DIEDLVKVGQRLKICPYFASRELVPQADITFMPYNYLLDPKARKANKIELGNTIVILD 252
            ..|    |||:||.:|::||.|||:.:|||:..|||.|.|||||||.:.|::..:.|...:||||
Human   329 QGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQIRESMDLNLKEQVVILD 393

  Fly   253 EAHNIEKICEESASVQIKSSDVAMAIEDVTHIMQVFASGESQDMAGDEPKDFTLDDLTLL----- 312
            ||||||....||||.            .||.:...||..|...|..:..:....:.|..:
Human   394 EAHNIEDCARESASY------------SVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLI 446

  Fly   313 ------------------------KEMLLELEKAIDAIVVDNAVDGTTFPASMMYELLGKANFTY 353
                                    .||||.|.|.        .:...|||            ...
Human   447 NWLEANAEYLVERDYESACKIWSGNEMLLTLHKM--------GITTATFP------------ILQ 491

  Fly   354 GNVATIVSLLDKLVQY----------LLVASQQMSIRKGGTFTLLSDLLTIVFANKEDVMSKVYA 408
            |:.:.::...:|:...          ::.||.|:.::  |.|.:|..|.      :::  |:...
Human   492 GHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLK--GLFMVLDYLF------RQN--SRFAD 546

  Fly   409 SFKVHVLVEESKQGHGKQQGAKQQGGWLGKGTIAAATGLSKVAK------------IINFWCFNP 461
            .:|:.:               :|...|..:..|:...||..:.|            ::||||.||
Human   547 DYKIAI---------------QQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNP 596

  Fly   462 GFGMEQLLNTQVRSVILTSGTLAPLKPLIAELAIPVAQHLENPHIVDQSQ--------------- 511
            ...... :|.:|::::||||||:|:|...:||.:.....||..||:..||
Human   597 AVAFSD-INGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQIMSSKFIIYVVACAR 660

  Fly   512 -----VYVKIIGTGPDRQQLISNYANRDNPKYISSLGQTILNVARIVPDGLLVFFPSYPMLNKCV 571
                 |:|..||:||..:.|.:.:.|.:..::...:|..:|:|.:.|..|:|.|.|||.:|.|..
Human   661 VSSLKVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLK 725

  Fly   572 DAWQASGLWADISCKKPIFLEPR--SKDQFTSTMEEFYQAIR---DSKGAVFMAVCRGKVSEGLD 631
            :.|.::|||.::...|.:.:||:  .|..|...::.:|.||:   :..||:.:||||||||||||
Human   726 ERWLSTGLWHNLELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLD 790

  Fly   632 FADRNGRAVIITGLPFPPLKDPKVILKRRYLEANRTRENQLLSGQEWYNLDATRAVNQAIGRVIR 696
            |:|.|.||||..|:|||.:||.:|.|||:|.: :.::...||.|::||.:.|.||:|||:||.||
Human   791 FSDDNARAVITIGIPFPNVKDLQVELKRQYND-HHSKLRGLLPGRQWYEIQAYRALNQALGRCIR 854

  Fly   697 HRNDYGAILLCDSRFKD--ASQVQQLSKWIRGHLGDRPQCSPFGPIVRELRQFFKNAE--ANMKL 757
            ||||:||::|.|.||::  :..:..||||:|..:...   |.|...:..|.:|.|..:  .|:.:
Human   855 HRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHH---STFESALESLAEFSKKHQKVLNVSI 916

  Fly   758 PDE---RETDSPLE-TVCK-------------------TEDEPLAAI-----PKVKRE----PGS 790
            .|.   ::.:|.|| |..|                   .|||....:     ||:..:    |.|
Human   917 KDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSS 981

  Fly   791 NATFKSANE--------SAIKVEMANSIK----------TWTPADYASAAGHKLGGAAPNAMDFM 837
            ..:.|..|:        .|.|:.::.|..          :|:.   .::.|....|..|.|...:
Human   982 IISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSS---FNSLGQYFTGKIPKATPEL 1043

  Fly   838 SRLDSNVSS-----------------------------IDFNCCTDSKSGSSGLVKI-----HKR 868
            ...:::.||                             ..|..|..|::..|.| ||     .|.
Human  1044 GSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSL-KIDATLTRKN 1107

  Fly   869 ERSSPTAPESS-------SQVTKKRYKLVENIKVEPSSSQAKEAPEERAAFLREL 916
            ....|...|.:       |.|:::..:...|...|      .||.:|...|..||
Human  1108 HSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFE------TEAEDESIYFTPEL 1156

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4078	NP_001259262.1	rad3	10..742	CDD:273169	263/949 (28%)
		DEAD_2	111..274	CDD:284209	73/169 (43%)
		Helicase_C_2	546..725	CDD:290046	84/185 (45%)
		HN_RTEL1	896..985	CDD:259826	7/21 (33%)
BRIP1	XP_011523634.1	rad3	245..901	CDD:273169	227/720 (32%)
		DEAD_2	248..415	CDD:284209	75/181 (41%)
		Helicase_C_2	700..886	CDD:290046	84/186 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53562
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3587
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.860