DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4078 and AT1G20750

DIOPT Version :9

Sequence 1:	NP_001259262.1	Gene:	CG4078 / 31497	FlyBaseID:	FBgn0029798	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_173498.3	Gene:	AT1G20750 / 838665	AraportID:	AT1G20750	Length:	1144	Species:	Arabidopsis thaliana

Alignment Length:	1113	Identity:	313/1113 - (28%)
Similarity:	453/1113 - (40%)	Gaps:	321/1113 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IAGIPVHFPFEPYPVQRAYMEKVIHCL----RDG-TNGVLESPTGTGKTLSLLCSSLAWIRTRQS 65
            |.|:.|.||::||..|.|:|.:||..|    ||| ::.:|||||||||:||||||.|||.::.:|
plant    29 IGGLQVEFPYQPYGTQLAFMSRVISTLDRAQRDGHSHALLESPTGTGKSLSLLCSVLAWQKSYKS 93

  Fly    66 EHQKQMVKMEKADFSGLGGGAPGGDLSELAKTM-----GRAN----NWGVPKVIYASRTHSQLTQ 121
            ..                   |.|:||. :||.     |.:|    ...:|.:.||||||:|:||
plant    94 RF-------------------PNGNLSH-SKTQPSDIAGSSNVEPHEPQIPTIYYASRTHAQITQ 138

  Fly   122 AMRELKRTAYANMRSVVLGSRDQLCIHPEVMREQGNSNKTNMCKLRVHSK---TCSFQMRVESRK 183
            .:||.::|.| .:...|||||.:.|.:..|   ||..|....|:|.:..|   .|:....|....
plant   139 VIREYRKTGY-RVPMTVLGSRKRYCTNSHV---QGKENVDEKCRLLLKDKKNIKCAEFNGVGRIL 199

  Fly   184 DHPDLRGP---TIMDIEDLVKVGQR-----LKICPYFASRELVPQADITFMPYNYLLDPKARKAN 240
            .:|.|:..   .:.|||||||:|:.     ||.....::.|     ||            ||:|.
plant   200 AYPSLQQTGHNGVHDIEDLVKIGKTVTGRLLKSFTVHSNME-----DI------------AREAG 247

  Fly   241 KIELGNTIVI-----LDEAHNIE--------KICEESASVQIKSSDVAMAIEDVTHIMQVFASGE 292
            .|.|...|:.     |::...:|        ::.|...|...:..| ::|..||.|    :.|..
plant   248 SINLEEDIIFKLKNELEQMSEVEPEIYDSLYEVVEGLISWIGRKKD-SLAKRDVDH----YFSNW 307

  Fly   293 SQDMAGDEPKDFTLDDLTLLKEMLLELEKAIDAIVVDNAVDGTTFPASMMYELLGKANFTYGNVA 357
            :.|.|..|.|:|.                    |..:|      ||..       ||.|......
plant   308 TGDRALKELKEFN--------------------ITREN------FPNL-------KACFNQAITK 339

  Fly   358 TIVSLLDKLVQYLLVASQQMSIRKGGTFTLLSDL---LTIVFANKEDVMSKVYASFKVHVLVEES 419
            :..:.:|....||          .|.:.:.|.:|   ||..|:....           |||..|.
plant   340 SEAAEIDPDKPYL----------SGISVSTLEELFATLTYFFSRNGS-----------HVLDYEM 383

  Fly   420 KQGHGKQQGAKQ-QGGWLGKGTIAAATGLSKVAKIINFWCFNPGFGMEQLLNTQVRSVILTSGTL 483
                |.|:.||: ..||               ....:.||.||....:.|.:..: |:|||||||
plant   384 ----GLQRSAKRGDNGW---------------TNTFSLWCMNPSVVFKDLADLSL-SIILTSGTL 428

  Fly   484 APLKPLIAELAIPVAQHLENPHIVDQS-QVYVKIIGTGPDRQQLISNYANRDNPKYISSLGQTIL 547
            :|:....:||.:.....||.||::|.: ||:...|.|.|....|.::|...:...:..:||:::.
plant   429 SPMNSFSSELGMQFGTCLEAPHVIDPNMQVWAGAISTVPGNYPLNASYRTAEAYAFQDALGKSLE 493

  Fly   548 NVARIVPDGLLVFFPSYPMLNKCVDAWQASGLWADISCKKPIFLEPR--SKDQFTSTMEEFYQAI 610
            .:..|||.|.|||||||.::.|....|..:|.|:.:..|..:|:|||  |||.|.:.::|:|.:|
plant   494 EICTIVPGGSLVFFPSYKLMEKLCTRWHETGQWSRLCLKTDLFIEPRGGSKDDFETVLKEYYDSI 558

  Fly   611 R------------------------DSK-GAVFMAVCRGKVSEGLDFADRNGRAVIITGLPFPPL 650
            .                        ||| |:.|:||||||||||:||:|.|.|||||.|:|.|.|
plant   559 SGKNRLIGRNSSVKKAGSVITEAQDDSKRGSAFLAVCRGKVSEGMDFSDDNARAVIIVGIPLPNL 623

  Fly   651 KDPKVILKRRYLEANRTRENQLLSGQEWYNLDATRAVNQAIGRVIRHRNDYGAIL---LCDSRFK 712
            .|..|.|||:|.:.|::.:| ||.|.|||...|.||:|||.||.||||.|||||:   :...|.
plant   624 GDILVELKRKYNDTNKSSKN-LLGGSEWYCQQAYRALNQAAGRCIRHRFDYGAIIFLVIVALRL- 686

  Fly   713 DASQVQQLSKWIRGHLGDRPQCSPFGPIVRELRQFFKNAEANMKLPDERE--------------- 762
                                      |..:|...:||.|:|::|:.|..|
plant   687 --------------------------PTTKEQSVYFKVAKASIKVYDNFEASMEGLRYFFSSVKE 725

  Fly   763 -TDSPL---------------ETVCKTED--------EPLAAIP-----KVKR------------ 786
             .||.:               |.|.|...        ||...||     :|||
plant   726 RVDSKMLESHEQNLSSENQRNEFVRKENQTQNKSSHVEPKQTIPAHTFIQVKREAECCKGVIDLD 790

  Fly   787 -----EPGSNATFKSAN-----ESAIKVEMANSIKTWTPADYASAAGHKL--GGAAPNAMD-FMS 838
                 |||........|     |::....|.|.|.|..|...:......|  |..:..:.| |:.
plant   791 CEVQPEPGYCEESSVTNCDEDPETSFVSGMINGIATARPCSSSKYESSSLETGLRSLKSPDQFLK 855

  Fly   839 RLDSNV----SSIDFNCCTDSKSGSSGLVKIHKRERSSPTAPESSSQVTKKRYKLVENIKV---E 896
            |..||.    |.:........:..|.|.::....|..||.....:|.|.|:|......|.:   |
plant   856 RHVSNANFRRSPLGAESSVTPERYSIGDMRNMTLEAESPLNMSVNSHVLKRRKFTTSPIIIDLEE 920

  Fly   897 PSSSQAKEAPEERAAFLREL-------------------RSLVTQDQFRRFGKALLEYKNGTYES 942
            .:|:.....||:..:|.|.:                   ||.::..:...:...:|...:.||
plant   921 ENSNAPDNRPEDHTSFTRRIEFGFPEVDQRVMRISCSLCRSTLSHPENNSYPICMLTSSSKTY-- 983

  Fly   943 FQALMAIL 950
               |:::|
plant   984 ---LLSLL 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4078	NP_001259262.1	rad3	10..742	CDD:273169	250/804 (31%)
		DEAD_2	111..274	CDD:284209	53/186 (28%)
		Helicase_C_2	546..725	CDD:290046	87/208 (42%)
		HN_RTEL1	896..985	CDD:259826	13/74 (18%)
AT1G20750	NP_173498.3	rad3	31..679	CDD:273169	249/768 (32%)
		P-loop_NTPase	32..>227	CDD:304359	80/218 (37%)
		Helicase_C_2	492..679	CDD:290046	86/187 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D186062at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820