DRSC/TRiP Functional Genomics Resources

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Protein Alignment Rtel1 and RTEL1

DIOPT Version :10

Sequence 1:NP_572254.1 Gene:Rtel1 / 31497 FlyBaseID:FBgn0029798 Length:985 Species:Drosophila melanogaster
Sequence 2:NP_001269938.1 Gene:RTEL1 / 51750 HGNCID:15888 Length:1300 Species:Homo sapiens


Alignment Length:1042 Identity:384/1042 - (36%)
Similarity:560/1042 - (53%) Gaps:140/1042 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MPESLIAGIPVHFPFEPYPVQRAYMEKVIHCLRDGTNGVLESPTGTGKTLSLLCSSLAWIRTRQS 65
            ||:.::.|:.|.|||:||..|:.||.||:.||:...||:|||||||||||.|||::|||     .
Human     1 MPKIVLNGVTVDFPFQPYKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAW-----R 60

  Fly    66 EHQKQMVKMEKADFSGLGGGAPGGDLSELAKTMGRANNWG---------------VPKVIYASRT 115
            ||.:..:...|......|...|...||          :||               :||:||||||
Human    61 EHLRDGISARKIAERAQGELFPDRALS----------SWGNAAAAAGDPIACYTDIPKIIYASRT 115

  Fly   116 HSQLTQAMRELKRTAYANMRSVVLGSRDQLCIHPEVMREQGNSNKTNMCKLRVHSKTCSFQMRVE 180
            ||||||.:.||:.|:| ..:..|||||:||||||||.:::.|..:.::|:.:|.|::|.|...||
Human   116 HSQLTQVINELRNTSY-RPKVCVLGSREQLCIHPEVKKQESNHLQIHLCRKKVASRSCHFYNNVE 179

  Fly   181 SRKDHPDLRGPTIMDIEDLVKVGQRLKICPYFASRELVPQADITFMPYNYLLDPKARKANKIELG 245
            .:....:|..| |:|||||||.|.:.::|||:.||.|..||||.|||||||||.|:|:|:.|:|.
Human   180 EKSLEQELASP-ILDIEDLVKSGSKHRVCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAHNIDLK 243

  Fly   246 NTIVILDEAHNIEKICEESASVQIKSSDVAMAIEDVTHIMQVFASGESQ-----DMAGDEPK--- 302
            .|:||.|||||:||:||||||..:...|:|..::.:..:::.......|     :.:.|.|.   
Human   244 GTVVIFDEAHNVEKMCEESASFDLTPHDLASGLDVIDQVLEEQTKAAQQGEPHPEFSADSPSPGL 308

  Fly   303 DFTLDDLTLLKEMLLELEKAIDAIVVDNAVDGTTFPASMMYELLGKANFTYGNVATIVSLLDKLV 367
            :..|:|:..||.:||.||.||||:.:.....|.|.|.|.::||..:|..|:.....|:..||:::
Human   309 NMELEDIAKLKMILLRLEGAIDAVELPGDDSGVTKPGSYIFELFAEAQITFQTKGCILDSLDQII 373

  Fly   368 QYLLVASQQMSIRKGGTFT------LLSDLLTIVFANKEDVMSK-------VYASFKVHVLVEES 419
            |:|        ..:.|.||      .|:|::.|||:......|.       ...|:|||:   ..
Human   374 QHL--------AGRAGVFTNTAGLQKLADIIQIVFSVDPSEGSPGSPAGLGALQSYKVHI---HP 427

  Fly   420 KQGHGKQQGAKQQGGWLGKGTIAAATGLSKVAKIINFWCFNPGFGMEQLLNTQVRSVILTSGTLA 484
            ..||  ::.|::...|       :.|...|..|::::|||:||..|.:|:...|||:||||||||
Human   428 DAGH--RRTAQRSDAW-------STTAARKRGKVLSYWCFSPGHSMHELVRQGVRSLILTSGTLA 483

  Fly   485 PLKPLIAELAIPVAQHLENPHIVDQSQVYVKIIGTGPDRQQLISNYANRDNPKYISSLGQTILNV 549
            |:.....|:.||....||||||:|:.|::|.::..|||..||.|.:..|.:.:.:||||:.:.|:
Human   484 PVSSFALEMQIPFPVCLENPHIIDKHQIWVGVVPRGPDGAQLSSAFDRRFSEECLSSLGKALGNI 548

  Fly   550 ARIVPDGLLVFFPSYPMLNKCVDAWQASGLWADISCKKPIFLEPRSKDQFTSTMEEFYQ--AIRD 612
            ||:||.|||:||||||::.|.::.|:|..|...:...||:|:|||||..|:.|:..:|.  |...
Human   549 ARVVPYGLLIFFPSYPVMEKSLEFWRARDLARKMEALKPLFVEPRSKGSFSETISAYYARVAAPG 613

  Fly   613 SKGAVFMAVCRGKVSEGLDFADRNGRAVIITGLPFPPLKDPKVILKRRYLEANRTR---ENQLLS 674
            |.||.|:||||||.||||||:|.|||.||:||||:||..||:|:||.::|:..:.:   ..|.||
Human   614 STGATFLAVCRGKASEGLDFSDTNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMKGQGGAGGQFLS 678

  Fly   675 GQEWYNLDATRAVNQAIGRVIRHRNDYGAILLCDSRFKDASQVQQLSKWIRGHLG--DRPQCSPF 737
            |||||...|:||||||||||||||.||||:.|||.||..|....||..|:|.|:.  |.     |
Human   679 GQEWYRQQASRAVNQAIGRVIRHRQDYGAVFLCDHRFAFADARAQLPSWVRPHVRVYDN-----F 738

  Fly   738 GPIVRELRQFFKNAEANMKLP---------------DERETDSPLETVCKTEDEPLAAIPKVK-R 786
            |.::|::.|||:.||..|..|               .|.::..|..:..|.:...| .:|.:| |
Human   739 GHVIRDVAQFFRVAERTMPAPAPRATAPSVRGEDAVSEAKSPGPFFSTRKAKSLDL-HVPSLKQR 802

  Fly   787 EPGSNATFKSANESAIKVEMANSIKTWTPADYASAAGHKLGGAAPNAMDFMSRLDSNVSSIDFNC 851
            ..||.|.....:...::.|.........|....:|..|                           
Human   803 SSGSPAAGDPESSLCVEYEQEPVPARQRPRGLLAALEH--------------------------- 840

  Fly   852 CTDSKSGSSGLVKIHK---RERSSPTAPESSSQVTKKRYKLVENIKVEPSSSQAKEAPEERAAFL 913
             ::.::||.|..:.|.   ....|...|....:..:|:.:||.:    |....|....:....|:
Human   841 -SEQRAGSPGEEQAHSCSTLSLLSEKRPAEEPRGGRKKIRLVSH----PEEPVAGAQTDRAKLFM 900

  Fly   914 RELRSLVTQDQFRRFGKALLEYKNGTYESFQALMAILLDVLSA-PKVRYMLVGMRKYLKNEHKDE 977
            ..::..::|..|..|.:||.:||..  :.|.||.|.|..:.:. ||...:|.|..::::..||.:
Human   901 VAVKQELSQANFATFTQALQDYKGS--DDFAALAACLGPLFAEDPKKHNLLQGFYQFVRPHHKQQ 963

  Fly   978 FD 979
            |:
Human   964 FE 965

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rtel1NP_572254.1 rad3 10..742 CDD:273169 328/774 (42%)
HN_RTEL1 896..985 CDD:259826 22/85 (26%)
RTEL1NP_001269938.1 rad3 10..743 CDD:273169 328/774 (42%)
Nuclear localization signal. /evidence=ECO:0000255|HAMAP-Rule:MF_03065 151..167 2/15 (13%)
DEAH box 250..253 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 287..306 3/18 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 757..786 3/28 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 839..877 7/65 (11%)
Nuclear localization signal. /evidence=ECO:0000255|HAMAP-Rule:MF_03065 871..877 0/5 (0%)
HN_RTEL1 877..976 CDD:259826 24/95 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 979..1005
PRK07764 <989..1240 CDD:236090
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1017..1054
HN_RTEL1 1052..1138 CDD:259826
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1132..1151
PIP-box 1178..1185
Blue background indicates that the domain is not in the aligned region.

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