DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4078 and rtel1

DIOPT Version :9

Sequence 1:	NP_001259262.1	Gene:	CG4078 / 31497	FlyBaseID:	FBgn0029798	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_001013328.2	Gene:	rtel1 / 503732	ZFINID:	ZDB-GENE-050306-11	Length:	1177	Species:	Danio rerio

Alignment Length:	1064	Identity:	389/1064 - (36%)
Similarity:	569/1064 - (53%)	Gaps:	169/1064 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPESLIAGIPVHFPFEPYPVQRAYMEKVIHCLRDGTNGVLESPTGTGKTLSLLCSSLAWIRTRQS 65
            ||...:.||.|.|||.|||.|..||.|||.||:...||||||||||||||.||||:|||     .
Zfish     1 MPVIKLKGINVDFPFTPYPCQEDYMSKVIECLQKKVNGVLESPTGTGKTLCLLCSTLAW-----R 60

  Fly    66 EHQKQMVKMEKADFSGLGGGAPGGDLSELAKTMGRA--------NNWG--------------VPK 108
            :|.|..:...|                 :.:.||.|        ::||              :||
Zfish    61 DHFKDTISARK-----------------ITERMGGAELFADRPMSSWGTAATDGDTPTYYTDIPK 108

  Fly   109 VIYASRTHSQLTQAMRELKRTAYANMRSVVLGSRDQLCIHPEVMREQGNSNKTNMCKLRVHSKTC 173
            :||||||||||||.:.|||.|:| ..:..|||||:||||:.||||.:.|..|.:||:.:|.|::|
Zfish   109 IIYASRTHSQLTQVVNELKNTSY-RPKICVLGSREQLCINQEVMRHESNHIKVHMCRAKVSSRSC 172

  Fly   174 SFQMRVESRKDHPDLRGPTIMDIEDLVKVGQRLKICPYFASRELVPQADITFMPYNYLLDPKARK 238
            .|...|:.:....::.. :|:|:|||||.|::.::|||:.||.|...||:.|||||||||||:|:
Zfish   173 IFYNNVDEKSTDKEIVN-SILDVEDLVKTGKKQRVCPYYLSRSLKQHADVIFMPYNYLLDPKSRR 236

  Fly   239 ANKIELGNTIVILDEAHNIEKICEESASVQIKSSDVAMAIEDVTHIMQVFASGESQDMAGDEPKD 303
            |:.|||...:||.|||||:||:||||.|..:...|:..|||.|..:::..||..|:   .|..:|
Zfish   237 AHNIELKGAVVIFDEAHNVEKMCEESTSFDLTPHDLISAIEAVDRLLREQASDISK---ADSAED 298

  Fly   304 FTLD--------DLTLL---KEMLLELEKAIDAIVVDNAVDGTTFPASMMYELLGKANFTYGNVA 357
            |.::        |:|.:   |::|::||.||:...:.....|.|.|.|.::||...||.......
Zfish   299 FNVESLNSGLKMDITTIAKVKQILMDLETAINDFEMPANNQGITKPGSFIFELFEMANVNSKTKT 363

  Fly   358 TIVSLLDKLVQYLL----VASQQMSIRKGGTFTLLSDLLTIVF------ANKEDVMSKVYASFKV 412
            ..|..::::..||.    |......::|      ::|::.:||      .:|:.........|||
Zfish   364 ETVEAMEQITGYLAGRPGVFLNTSGLQK------VADIIQLVFVAEPAEGSKKSQTGNSLKEFKV 422

  Fly   413 HVLVEESKQGHGKQQGAKQQ---GGWLGKGTIAAATGLSKVAKIINFWCFNPGFGMEQLLNTQVR 474
            |:        |......|::   ..|       |::...|...::::|||:|||.|::||..:||
Zfish   423 HI--------HPDNSNFKKKQITDVW-------ASSSTKKQGNVLSYWCFSPGFSMQELLRQEVR 472

  Fly   475 SVILTSGTLAPLKPLIAELAIPVAQHLENPHIVDQSQVYVKIIGTGPDRQQLISNYANRDNPKYI 539
            .:|||||||:||.....|:.||....|||||::.:.|::|.||..|||..||.:.:..|..|:.:
Zfish   473 CIILTSGTLSPLSSFTCEMQIPFPVSLENPHVIQRDQIFVSIIEKGPDGVQLSTAFDRRFVPENM 537

  Fly   540 SSLGQTILNVARIVPDGLLVFFPSYPMLNKCVDAWQASGLWADISCKKPIFLEPRSKDQFTSTME 604
            ||:|.|::|::|:||.||||||||||:::|.::.|:|.|....|...||:|:|||.|..||..::
Zfish   538 SSMGNTLVNLSRVVPHGLLVFFPSYPVMDKTLEFWRAKGHADRIENVKPMFVEPRGKGTFTEVID 602

  Fly   605 EFYQAIRD--SKGAVFMAVCRGKVSEGLDFADRNGRAVIITGLPFPPLKDPKVILKRRYLE---A 664
            .:|..:.|  |.|..|.||||||.||||||||..||.|:||||||||..||:|:||.:||:   .
Zfish   603 GYYGKVDDPNSSGGSFFAVCRGKASEGLDFADTYGRGVVITGLPFPPRMDPRVVLKMQYLDEMCR 667

  Fly   665 NRTRENQLLSGQEWYNLDATRAVNQAIGRVIRHRNDYGAILLCDSRFKDASQVQQLSKWIRGHL- 728
            |:....:.|:|||||...|:||||||||||||||.|||||.|||.|||.|....||..|:|.::
Zfish   668 NKISGVKYLTGQEWYRQQASRAVNQAIGRVIRHREDYGAIFLCDHRFKSADARNQLPSWVRPYVK 732

  Fly   729 ---GDRPQCSPFGPIVRELRQFFKNAEANMKLP--------DERETDSPLETVCKTEDEPLAAIP 782
               |       ||.:||::.|||:.|:....:|        .|.:.|:.|
Zfish   733 IYDG-------FGTMVRDVAQFFRTAQKTRPVPVKKGKAEGHENQADTRL--------------- 775

  Fly   783 KVKREPGSNATFKSANESAIKVEMANSIKTWTPA------DYASAAGHKLGGAAPNAMDFMSRLD 841
               ...||:...||...|.| .:.|.::....|:      |....:|.:  |||...:.:...:.
Zfish   776 ---LNTGSSCLTKSVWPSDI-YQKAKTLDAHVPSLKRRKLDSEEHSGRE--GAARLCIQYEMEMT 834

  Fly   842 SN---VSSID-FNCCTDSKSGSSGLVKIHKRERSSPTAP---------ESSSQVTKKRYKLVENI 893
            |.   ||.:| .:..||.:.....:|   ..||:|..:.         :..|:..|::.|:|:.
Zfish   835 SKRKPVSLLDALDDTTDKEEREDTMV---GEERASHLSTLSLQHDKRLDDESRGGKRKIKVVQE- 895

  Fly   894 KVEPSSSQAKEAPEERAAFLRELRSLVTQDQFRRFGKALLEYKNGTYESFQALMAILLD-VLSAP 957
            :...:|..||..    .||:.|||..::.:.|:...:||..||  |.::...|:|.:.: ::...
Zfish   896 RETVTSHTAKTG----KAFMMELRRCLSHENFKLIMEALQSYK--TADNLNNLLATVAEPLIQDH 954

  Fly   958 KVRYMLVGMRKYLKNEHKDEFDRR 981
            ....:|.|:.::::..||.|:|.|
Zfish   955 NTHSLLRGLYQFIRPHHKKEYDER 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4078	NP_001259262.1	rad3	10..742	CDD:273169	325/786 (41%)
		DEAD_2	111..274	CDD:284209	84/162 (52%)
		Helicase_C_2	546..725	CDD:290046	102/183 (56%)
		HN_RTEL1	896..985	CDD:259826	23/87 (26%)
rtel1	NP_001013328.2	rad3	13..742	CDD:273169	324/783 (41%)
		DEAD_2	111..272	CDD:284209	84/162 (52%)
		Nuclear localization signal. /evidence=ECO:0000255\|HAMAP-Rule:MF_03065	151..167		6/15 (40%)
		DEAH box	250..253		2/2 (100%)
		Helicase_C_2	544..730	CDD:290046	103/185 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	847..869		6/24 (25%)
		Nuclear localization signal. /evidence=ECO:0000255\|HAMAP-Rule:MF_03065	883..889		2/5 (40%)
		HN_RTEL1	889..987	CDD:259826	25/97 (26%)
		HN_RTEL1	1041..1144	CDD:259826
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593535
Domainoid	1	1.000	210	1.000	Domainoid score	I2773
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H13168
Inparanoid	1	1.050	609	1.000	Inparanoid score	I886
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	1	1.000	-	-		FOG0006111
OrthoInspector	1	1.000	-	-		oto40613
orthoMCL	1	0.900	-	-		OOG6_102317
Panther	1	1.100	-	-	LDO	PTHR11472
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3587
SonicParanoid	1	1.000	-	-		X4406
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790