DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4078 and ddx11

DIOPT Version :9

Sequence 1:	NP_001259262.1	Gene:	CG4078 / 31497	FlyBaseID:	FBgn0029798	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_001007320.1	Gene:	ddx11 / 492353	ZFINID:	ZDB-GENE-041114-191	Length:	890	Species:	Danio rerio

Alignment Length:	954	Identity:	235/954 - (24%)
Similarity:	372/954 - (38%)	Gaps:	284/954 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 FPFEPYPVQRAYMEKVIHCLRDGTNGVLESPTGTGKTLSLLCSSLAWIRTRQSEHQKQMVKM--- 74
            |||:|||:|.::||.:...|.....|:.||||||||:|||:|.:|.|:|..:.:.:::..::
Zfish    10 FPFQPYPIQESFMEALYTALDQRKVGIFESPTGTGKSLSLICGALTWLRDYEEQRKQEAARLLEG 74

  Fly    75 --------EKADFSGLGGGAPGGD-LSELAK-------------------------TMGRAN--- 102
                    ||...|    |.|..| :||..:                         .|.|.|
Zfish    75 QKDSDVVKEKNSNS----GPPEPDWVSEFVQKKAERDMVNKLKDEELKRKKREERLEMIRHNAQL 135

  Fly   103 ----------------------------------------------------------------- 102

Zfish   136 RYAMKRKADEDDEAVKLLQLSREGSEPETHSPEEEGLIVAEYESDDEATPKSRLCDDDNDDDDDL 200

  Fly   103 -NWGVPKVIYASRTHSQLTQAMRELKRTAYAN-MRSVVLGSRDQLCIHPEVMREQGNSNKTNMCK 165
             ...|.|:.|.|||||||.|.:.|::::.|.: :|.|.||||..|||:|||:| .||....|...
Zfish   201 EEEHVTKIYYCSRTHSQLAQFVHEVQKSPYGDAVRLVNLGSRQNLCINPEVVR-LGNVQMMNERC 264

  Fly   166 LRV----HSK------------------TCSFQMRVESRKDHPDLRGPTIMDIEDLVKVGQRLKI 208
            |.:    |.|                  ||.|. |.|:.....|.....:.|:|.|::.|:....
Zfish   265 LEMQKNKHEKRQKASDSESKRSRGLAKATCVFS-RFENLMAMKDEVLVKVRDVEQLIQHGRETHT 328

  Fly   209 CPYFASRELVPQADITFMPYNYLLDPKARKANKIELGNTIVILDEAHNIEKICEESASVQIKSSD 273
            |||:::|..:|.|.:..:||..||....|||:.|:|.:.|||:|||||:........|.:|....
Zfish   329 CPYYSTRMSIPAAQVVVLPYQSLLHASTRKASGIKLKDQIVIIDEAHNLMDTISAIHSAEISGGQ 393

  Fly   274 VAMAIEDVTHIMQVFASGESQDMAGDEPKDFTLDDLTLLKEMLLELEKAIDAIVVDNAVDGTTFP 338
            :..|...::...:.:.|            .....:|..:|::|..||
Zfish   394 LCRAHSQLSQYCERYRS------------RLKAKNLMYIKQILFVLE------------------ 428

  Fly   339 ASMMYELLGKANFTYGNVATIVSLLDKLVQYLLVASQQMSIRKGGTFTLLSDLLTIVFANKEDVM 403
             .::..|.||..   .|..|                  .|.:.|      |:||||     .|.:
Zfish   429 -GLVRTLGGKVG---QNPNT------------------QSCQTG------SELLTI-----NDFL 460

  Fly   404 SKVYAS----FKVHVLVEESK------------QGHG--------KQQGAKQQGGW--------- 435
            .|....    |||....|:|.            :|.|        .::..:.:|.|
Zfish   461 FKAQVDNINLFKVQKYFEKSMISRKLCGFAEKYEGSGINTHSSSKNKENRRTEGLWRFLQTLQSK 525

  Fly   436 ----------------------LGKGTIAAATGLSKVAKII------------NFWCFNPGFGME 466
                                  |.:..:.|.|..:|..:|:            .|...|......
Zfish   526 PTDVSEQQMAVEDKPIMASPMMLAESFLFALTNANKDGRIVIQRQACVAQSSLKFLLLNAAVHFA 590

  Fly   467 QLLNTQVRSVILTSGTLAPL----KPLIAELAIPVAQHLENP--HIVDQSQVYVKIIGTGPDRQQ 525
            |:|. :.|:||:..||:.|:    :.|:....:...:.||..  |::....:...::..||..||
Zfish   591 QILQ-ECRAVIIAGGTMQPVADFKEQLLFSAGVTEERILEFSCGHVIPPENILPIVLCAGPSGQQ 654

  Fly   526 LISNYANRDNPKYISSLGQTILNVARIVPDGLLVFFPSYPMLNKCVDAWQASGLWADISCKKPIF 590
            |...:..||:|:.:...|:.:.|:..|||.|::.|||||....:.:..|:::|:...:..||.||
Zfish   655 LEFTFQTRDSPQMMEETGRVLSNLCNIVPGGVVCFFPSYEYEKRILGHWESTGILQRLQSKKKIF 719

  Fly   591 LEPRSKDQFTSTMEEFYQAIR-------DSKGAVFMAVCRGKVSEGLDFADRNGRAVIITGLPFP 648
            .||:...|....:.|:.:.|:       ...||:..:|..||:|||::|:|..||.:::.|:|:|
Zfish   720 QEPKKASQVEQVLSEYSKCIQRCSNIGGGQTGALLFSVVGGKMSEGINFSDDLGRCIVMVGMPYP 784

  Fly   649 PLKDPKVILKRRYLEANRTRENQLLSGQEWYNLDATRAVNQAIGRVIRHRNDYGAILLCDSRFKD 713
            .:|.|::..|..||:.:.........|:........:||||:|||.||||.||..|:|||.|:..
Zfish   785 NIKSPELQEKMAYLDKHMPHVAGKSPGKALVESLCMKAVNQSIGRAIRHRGDYACIVLCDHRYAR 849

  Fly   714 ASQVQQLSKWIRGHLGDRPQCSPFGPIVRELRQFF--KNAEANM 755
            ...:|:|.:|||......   :.|||.....|:||  |..:|.:
Zfish   850 TGTLQKLPEWIRSSTHTH---ATFGPAFASARRFFLEKRQKATL 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4078	NP_001259262.1	rad3	10..742	CDD:273169	230/937 (25%)
		DEAD_2	111..274	CDD:284209	65/185 (35%)
		Helicase_C_2	546..725	CDD:290046	63/185 (34%)
		HN_RTEL1	896..985	CDD:259826
ddx11	NP_001007320.1	P-loop_NTPase	8..416	CDD:304359	106/423 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..95		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..199		0/22 (0%)
		rad3	205..877	CDD:273169	193/740 (26%)
		DEAH box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	372..375		2/2 (100%)
		Helicase_C_2	675..863	CDD:290046	65/187 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820