Protein Alignment Rtel1 and Brip1

DIOPT Version :10

• Sequence 1: NP_572254.1
• Gene: Rtel1 / 31497
• FlyBaseID: FBgn0029798
• Length: 985
• Species: Drosophila melanogaster
• Sequence 2: NP_001417159.1
• Gene: Brip1 / 360588
• RGDID: 1307659
• Length: 1166
• Species: Rattus norvegicus
• Alignment Length: 1195
• Identity: 316/1195 - (26%)
• Similarity: 494/1195 - (41%)
• Gaps: 337/1195 - (28%)

  Fly     1 MPESLIAGIPVHFPFEPYPVQRAYMEKVIHCLRDGTNGVLESPTGTGKTLSLLCSSLAW------ 59
            :.|..|.|:.:|||...||.|.|.|..::..|....:.:||||||:||:|:||||:|||
  Rat     5 LSEYTIGGVKIHFPCRAYPAQLAMMNSIVRGLNSSQHCLLESPTGSGKSLALLCSALAWQQSLTG 69

  Fly    60 ----------------------------------------------------------------- 59
                                                                             
  Rat    70 KPVDEGLNKKPEAPSSCSCSCHSKNFTYSDTNLDTSPHFSSPSKPSSERNAVSSPCRDSPERNSL 134

  Fly    60 -----IRTRQSEHQKQMVKMEK------------------------------------------- 76
                 .:...|.|:....::||
  Rat   135 AAKLSAKKHASIHEDDDFQVEKKRIRPLETTQQIRKRHCLEKDVHHLDARLASEKRVKPESPIRK 199

  Fly    77 --ADFSGLGG-------GAPGGDLSELAKTMGRAN--NWGVPKVIYASRTHSQLTQAMRELKRTA 130
              :.|....|       .|..|...|.|.|:.:.|  ....||:.:.:|||.|:.|..|||::||
  Rat   200 TSSSFQNPDGLCSRCCCSANQGINKESANTVKKDNGDQSKRPKIYFGTRTHKQIAQITRELRKTA 264

  Fly   131 YANMRSVVLGSRDQLCIHPEVMREQGNSNKTNMCKLRV---HSKTCSFQ---MRVESRKDHPDLR 189
            |:.:...:|.|||..|:||||:   ||.|:...|...:   |.|:|.|.   .|:.:::....|.
  Rat   265 YSGVPMTILSSRDHTCVHPEVV---GNFNRNEKCMELLDGKHGKSCYFYHGVHRISNQQTLQFLH 326

  Fly   190 G-PTIMDIEDLVKVGQRLKICPYFASRELVPQADITFMPYNYLLDPKARKANKIELGNTIVILDE 253
            | ....|||:||.:|::||.|||:.:|||:..|||.|.|||||||.:.|::..|:|...:|||||
  Rat   327 GISKAWDIEELVSLGRKLKACPYYTARELIDSADIIFCPYNYLLDSQIRESMDIKLKEQVVILDE 391

  Fly   254 AHNIEKICEESASVQIKSSDVAMAIEDVTHIMQVFASGESQDMAGDEP-KDFTLDDLTLLK---- 313
            |||||:...|:||..:....:..|.:::..::......:|.     || :|...:.:..|:
  Rat   392 AHNIEECARETASYSVTEVQLRFARDELDSLINSNIRKKSH-----EPLRDVCYNLINWLETNSK 451

  Fly   314 -----------------EMLLELEKAIDAIVVDNAVDGTTFPA-----SMMYELLGKANFTYGNV 356
                             ||||.|.:.        .:...:||.     |.:.:...|...|:|.
  Rat   452 NLVERDYESSCKIWSGNEMLLNLHRM--------GITAASFPVLQKHLSAVLQKEEKVTSTHGK- 507

  Fly   357 ATIVSLLDKLVQY-LLVASQQMSIRKGGTFTLLSDLLTIVFANKEDVMSKVYASFKVHVLVEESK 420
                   ::.:|. ::.||.|:.::  |.|.:|..|.     .|.   |:....:||.:
  Rat   508 -------EEAIQIPIISASTQIMLK--GLFMVLDYLF-----RKN---SRFADDYKVAI------ 549

  Fly   421 QGHGKQQGAKQQGGWLGKGTIAAATGLSKVAK------------IINFWCFNPGFGMEQLLNTQV 473
                     :|...|..:..|.....|..|.|            ::||||.||...... :|.:|
  Rat   550 ---------QQTYSWTNQIAIFDKNALLPVPKNKKHSRQKIGVNVLNFWCLNPAVAFSD-INDKV 604

  Fly   474 RSVILTSGTLAPLKPLIAELAIPVAQHLENPHIVDQSQVYVKIIGTGPDRQQLISNYANRDNPKY 538
            |:::||||||:|||...:||.:.....||..|::..|||:|..:|:||..:.|.:.:.:.:..::
  Rat   605 RTIVLTSGTLSPLKSFSSELGVTFNIQLEANHVISNSQVWVGTVGSGPKGRNLCATFQHTETFEF 669

  Fly   539 ISSLGQTILNVARIVPDGLLVFFPSYPMLNKCVDAWQASGLWADISCKKPIFLEPR--SKDQFTS 601
            ...:|..:|:|.:.|..|:|.|.|||.:|.|..:.|..:|||..:...|.:..||:  .|..|..
  Rat   670 QDEVGMLLLSVCQTVSQGILCFLPSYKLLEKLRERWIFTGLWHSLESVKTVIAEPQGGEKTDFDE 734

  Fly   602 TMEEFYQAIR---DSKGAVFMAVCRGKVSEGLDFADRNGRAVIITGLPFPPLKDPKVILKRRYLE 663
            .::.:|.||:   :..||:.:|||||||||||||:|.|.||||..|:|||.:||.:|.|||:|.:
  Rat   735 LLQVYYDAIKFKGEKDGALLIAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYND 799

  Fly   664 ANRTRENQLLSGQEWYNLDATRAVNQAIGRVIRHRNDYGAILLCDSRFKDASQ--VQQLSKWIRG 726
             :.::...||.|::||.:.|.||:|||:||.|||:||:||::|.|.||.:...  :..||||:|.
  Rat   800 -HHSKLRGLLPGRQWYEIQAYRALNQALGRCIRHKNDWGALILVDDRFNNNPDRYISGLSKWVRQ 863

  Fly   727 HLGDRPQCSPFGPIVRELRQFFKNAE--ANMKLPDE---RETDSPLETVC--------------K 772
            .:...   |.|...:..|.:|.|..:  .|....:|   :|..|.|:..|              :
  Rat   864 QIQHH---STFASALESLTEFSKRHQKVTNRSKKEEKCTKENGSTLDVACLEGSTLTSVSEASHQ 925

  Fly   773 TEDEPLAAIPKV--------------------------KREPG-------------------SNA 792
            |.:..|....||                          :.:||                   |:.
  Rat   926 TPENSLEEEAKVCVQEQRYPQMAAENPSGPSHGVSRRKESDPGLREKSVQTMKTEKSEISRSSSP 990

  Fly   793 TFKSANE-------SAIKVEMANSIKTWTPADYASAAGHKLGGAAPN--AMDFMSRLDSNVSSID 848
            ||....|       :::|....:.:|..||. ..|:..|....:|.|  |:....:..|  ||..
  Rat   991 TFGKQTEPVNWPIFNSLKRHFNSKVKNRTPV-LKSSKNHASASSAFNKTALPLTGKCVS--SSAP 1052

  Fly   849 FNC----CTDSK------SGSSGLVKIHKRERSSPTAPESS-SQVTKKRYKLVENIKVEPSSSQ- 901
            .|.    |..|:      ...:...|.|.::.....:|::. |.||:         :.:.|||.
  Rat  1053 ANTPLAPCPQSEVIIPSVKADTTPAKTHCKQNEKDPSPDAELSPVTE---------EAKGSSSNP 1108

  Fly   902 --AKEAPEERAAFLRELRSLVTQDQ 924
              ..|..::...|..||...|:.|:
  Rat  1109 AVGTEVDDDSVCFTPELFDPVSTDE 1133

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rtel1	NP_572254.1	rad3	10..742	CDD:273169	264/915 (29%)
		HN_RTEL1	896..985	CDD:259826	9/32 (28%)
Brip1	NP_001417159.1	PRK08074	<25..>72	CDD:236148	20/46 (43%)
		rad3	242..878	CDD:273169	226/689 (33%)