DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4078 and Ddx11

DIOPT Version :9

Sequence 1:	NP_001259262.1	Gene:	CG4078 / 31497	FlyBaseID:	FBgn0029798	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_001335221.1	Gene:	Ddx11 / 320209	MGIID:	2443590	Length:	906	Species:	Mus musculus

Alignment Length:	928	Identity:	228/928 - (24%)
Similarity:	383/928 - (41%)	Gaps:	221/928 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IAGIPVHFPFEPYPVQRAYMEKVIHCLRDGTNGVLESPTGTGKTLSLLCSSLAWIRTRQSEHQKQ 70
            |.||...|||.|||:|:.:|.::...|..|..|:.||||||||:|||:|.:|:|:|    :.:|:
Mouse     8 IGGIHFPFPFPPYPIQKDFMAELYKVLEGGKIGIFESPTGTGKSLSLICGALSWLR----DFEKK 68

  Fly    71 MVKMEKADFSGLGGGAPGGD--------------------------------------------- 90
            .::.| |.....|.|.|..:
Mouse    69 KLQAE-ALLLAPGSGPPSSEKNSLLTSSSCQEPTDTPRPAGEPDWVTEFVQKKEERDLVERLREE 132

  Fly    91 ------------------------------------LSELAKTMGRANNW--------------- 104
                                                |..|::.|..|...
Mouse   133 QVRRRKREERLKEVCQDGRLRFAAKRTKHEEEETEALLRLSREMLDAGTGPEQLEQLECGEEHLV 197

  Fly   105 -------------------------GVPKVIYASRTHSQLTQAMRELKRTAYA-NMRSVVLGSRD 143
                                     .:.|:.|.|||||||.|.:||:.::.:. ..|.|.||||.
Mouse   198 LAEYESDEERRGSRVDEAEDDLEEEHITKIYYCSRTHSQLAQFVREVLKSPFGKETRLVSLGSRQ 262

  Fly   144 QLCIHPEV-------------------MREQGNSNKTNMCKLRVHSKT-CSF--QMRVESRKDHP 186
            .||::.:|                   .||:..:.:....:.|...:| |.|  ..::|..:|..
Mouse   263 TLCVNEDVKNLGSVQLMNDRCVDMQRSKREKNGTGEDKPKRKRQKIQTSCPFYNHEQMELLRDEI 327

  Fly   187 DLRGPTIMDIEDLVKVGQRLKICPYFASRELVPQADITFMPYNYLLDPKARKANKIELGNTIVIL 251
            .|.   :.|:|.||.:|:..:.|||:.||..:|.|.:..:||..||....|:|..|.|...:||:
Mouse   328 LLE---VKDMEQLVALGKEARACPYYGSRFAIPAAQLVVLPYPMLLHAATRQAAGIRLQGQVVII 389

  Fly   252 DEAHNIEKICEESASVQIKSSDVAMAIEDVTHIMQVFASGESQDMAGDEPKDFTLDDLTLLKEML 316
            |||||:........|.::..|.:..|...:...|:.:.            |.....:|..:|::|
Mouse   390 DEAHNLIDTITNIHSTEVNGSQLCQAHSQLLQYMERYR------------KRLKAKNLMYIKQIL 442

  Fly   317 LELEKAIDAIVVDNAVDGTTFPASMM--YELLGKANFTYGNVATIVSLLDKLVQYLLVASQQMSI 379
            ..|||.: |::..|.....|..:...  .||....:|.:.:....::|. |:.:||   .:.|..
Mouse   443 YLLEKFV-AVLGGNVKQNPTTQSLSQTGSELKSINDFLFQSQVDNINLF-KVQRYL---EKSMLS 502

  Fly   380 RKGGTFTLLSDLLTIVFANKEDVM-SKVYASFKVHVLVEESKQGHGKQQGAKQQGGWLG------ 437
            ||...||   :...:|..:..|.. ::..|.|:..:...:|    |..:.:.::|..:.
Mouse   503 RKLFGFT---ECFGVVLPSLSDSQENRGLAGFQQFLKSLQS----GPTEDSPEEGQAVALRPASP 560

  Fly   438 ----KGTIAAATGLSKVAKII------------NFWCFNPGFGMEQLLNTQVRSVILTSGTLAPL 486
                :..:||.|..::..::|            .|...||.....|::. :.|:|::..||:.|:
Mouse   561 LMHIEAFLAALTTANQDGRVIVNRQGSVGQSSLKFLLLNPAVHFAQVVK-ECRAVVIAGGTMQPM 624

  Fly   487 ----KPLIAELAIPVAQHLENP--HIVDQSQVYVKIIGTGPDRQQLISNYANRDNPKYISSLGQT 545
                :.|:|...:...:.:|..  |::....:...||.:||..|||...|..|:.|:.:...|:.
Mouse   625 SDFREQLLACSGVEAGRVVEFSCGHVIPPDNILPLIICSGPSNQQLEFTYQRRELPQMVEETGRI 689

  Fly   546 ILNVARIVPDGLLVFFPSYPMLNKCVDAWQASGLWADISCKKPIFLEPRSKDQFTSTMEEFYQAI 610
            :.|:..:||.|::.|.|||..|.:....|..:||...:|.:|.||.||:...|....:..:.:.|
Mouse   690 LCNLCNVVPGGVVCFLPSYEYLRQVHAHWDKTGLLTRLSVRKKIFQEPKRASQVEQVLMAYSKCI 754

  Fly   611 RDSK-------GAVFMAVCRGKVSEGLDFADRNGRAVIITGLPFPPLKDPKVILKRRYLEANRTR 668
            ....       ||:.::|..||:|||::|:|..||.|::.|:|:|.:|.|::..|..||.....|
Mouse   755 MSCSHSEGHLTGALLLSVVGGKMSEGINFSDDLGRCVVMVGMPYPNIKSPELQEKMAYLNQTLPR 819

  Fly   669 -ENQLLSGQEWYNLDATRAVNQAIGRVIRHRNDYGAILLCDSRFKDASQVQQLSKWIRGHLGDRP 732
             :.|.|.|.........:|:||:|||.|||:.|:.:|:|.|.|:...|.:.:|..|||    ||.
Mouse   820 TQGQPLPGTVLIENLCMKAINQSIGRAIRHQRDFASIVLLDHRYARPSILAKLPAWIR----DRV 880

  Fly   733 QC-SPFGPIVRELRQFFK 749
            :. :.|||....:|:|.:
Mouse   881 EVKATFGPAFAAVRKFHR 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4078	NP_001259262.1	rad3	10..742	CDD:273169	223/915 (24%)
		DEAD_2	111..274	CDD:284209	58/185 (31%)
		Helicase_C_2	546..725	CDD:290046	62/186 (33%)
		HN_RTEL1	896..985	CDD:259826
Ddx11	NP_001335221.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..111		3/32 (9%)
		rad3	225..889	CDD:273169	186/695 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..310		3/25 (12%)
		DEAH box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	390..393		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820