DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4078 and CG11403

DIOPT Version :9

Sequence 1:	NP_001259262.1	Gene:	CG4078 / 31497	FlyBaseID:	FBgn0029798	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_569898.1	Gene:	CG11403 / 31072	FlyBaseID:	FBgn0026876	Length:	861	Species:	Drosophila melanogaster

Alignment Length:	886	Identity:	222/886 - (25%)
Similarity:	367/886 - (41%)	Gaps:	195/886 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 FPFEPYPVQRAYMEKVIHCLRDGTNGVLESPTGTGKTLSLLCSSLAWI----------------- 60
            ||:.||.:|...|:::...|..|..|:.||||||||:|:|.|.:|.|:
  Fly    20 FPYSPYEIQEQLMQELFQVLERGQVGIFESPTGTGKSLTLTCGALTWLARHEELVRTEMLARIRG 84

  Fly    61 -------------------------RTRQSE-----HQKQMVKMEKADFSGLGGGAP-------- 87
                                     |.:::|     |.:.::..::.....:..||.
  Fly    85 VEQELAKLKEESEQSSNWLESQGKSRAQRAELLRLQHLQALLDKQEQQLDQIRKGAKKHKRQGRV 149

  Fly    88 -GGDLSELAKTM------------------GRANNWGVPKVIYASRTHSQLTQAMRELKRTAYA- 132
             .|.|.||.|.:                  ...:.:...::.:.|||||||.|.:.||::|.:.
  Fly   150 HPGKLEELEKDLDPESDSDSEHETADGPQEAAEDRYRPVQIFFCSRTHSQLAQIVAELRKTPHGQ 214

  Fly   133 NMRSVVLGSRDQLCIHPEVMR----------------EQGNSNKTNMCKLRVHSKT-CSFQMR-- 178
            ::||:.||||.|||.:|.|.:                ::...|.:...:|...:.: |.|:..
  Fly   215 SVRSISLGSRQQLCGNPAVRKLKHVGLMNERCLDMATKKARPNPSKKSRLTAEANSRCPFKAASL 279

  Fly   179 VESRKDHPDLRGPTIMDIEDLVKVGQRLKICPYFASRELVPQADITFMPYNYLLDPKARKANKIE 243
            |||.:|.. |..|  :|||:|...|.....|.|:|||..|..|.:..:||..||...||....|.
  Fly   280 VESLRDLA-LTEP--LDIEELANEGTACGGCSYYASRSAVEHAQLILLPYQLLLQKSARNQLGIS 341

  Fly   244 LGNTIVILDEAHNIEKICEESASVQIKSSDVA-MAIEDVTHIMQVFASGESQDMAGDEPKDFTLD 307
            |..:|||:|||||:     ..:..|:..|::: ..:|..    :|..||.....    .|.||..
  Fly   342 LKGSIVIVDEAHNL-----LDSVAQLHGSEISRQQLERA----KVQISGYKDHF----QKRFTTK 393

  Fly   308 DLTLLKEMLLELEKAIDAIVVDNAVDGTTFPASMM--YELLGKANFTYGNVATI----------- 359
            :|..:.:::..:.:.:.  ::|...:..:...|||  |||..:.:|...::..:
  Fly   394 NLLKINQIIFIIRRLLK--ILDQRKELQSNGCSMMRTYELTAEGDFFNIDLCELLDFCARTRFAR 456

  Fly   360 ---------------------VSLLDKLVQYLLVASQQMSIRKGGTFTLLSDLLTIVFANKEDVM 403
                                 ||....|:...|.:.|::..:.......:.|:      ||||
  Fly   457 KVQGRADRMEREPRPSENQAPVSTARSLILQRLASEQKLKEKTKSVKRRVEDI------NKED-- 513

  Fly   404 SKVYASFKVHVLVEESKQGHGKQQGAKQQG-----GWLGKGTIAAATG---LSKVAKIINFWCFN 460
                   |...|.|:.|......:......     .:|...|..|..|   :..|...:.:...:
  Fly   514 -------KAEELQEQQKPTKKPVEEVAPSPIRPLLAFLETLTSNAEDGRILVDPVGGTLKYILLD 571

  Fly   461 PGFGMEQLLN--TQVRSVILTSGTLAPLKPLIAELAIPVAQHLEN---PHIVDQSQVYVKIIGTG 520
            |.   ||..:  .:.|::::..||:.|.|.|..:|.......|..   .|:|....:...:|..|
  Fly   572 PA---EQFADIVAEARAIVIAGGTMQPTKELKEQLFTGCHDRLVERFYNHVVANDAILPFVISNG 633

  Fly   521 PDRQQLISNYANRDNPKYISSLGQTILNVARIVPDGLLVFFPSYPMLNKCVDAWQASGLWADISC 585
            |....|...:|:|.:.:.:..|...:.|:.::||.|::.|.|||..|:|.....:.||....||.
  Fly   634 PSGAPLSFKFAHRGSAEMLRELSMILRNLCQVVPGGVVCFLPSYEYLDKVYKYLEQSGTLETISG 698

  Fly   586 KKPIFLE-PRSKDQFTSTMEEFYQAIR--DSKGAVFMAVCRGKVSEGLDFADRNGRAVIITGLPF 647
            :|.:|.| ..|.:|.   ::.:..||:  .|.||:.::|..||:||||:|||..||||::.|||:
  Fly   699 RKSVFREVSGSAEQL---LDNYALAIKRPASYGALLLSVVGGKLSEGLNFADDLGRAVLVVGLPY 760

  Fly   648 PPLKDPKVILKRRYLEANRTRENQLL---SGQEWYNLDATRAVNQAIGRVIRHRNDYGAILLCDS 709
            .....|::..:.::|:       :.|   :|.|:|.....:||||.|||.:||..||..:.|.|.
  Fly   761 SNSLSPELRQRMQHLD-------EKLGPGAGNEYYENLCVKAVNQCIGRAVRHIKDYACVYLLDK 818

  Fly   710 RFKDASQVQQLSKWIRGHLGDRPQCS-PFGPIVRELRQFFK 749
            ||.|.....:|.|||..|:.:....: .||.:.....:|||
  Fly   819 RFADPKIRGKLPKWISRHIVEANAANGGFGAVQGRTARFFK 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4078	NP_001259262.1	rad3	10..742	CDD:273169	219/877 (25%)
		DEAD_2	111..274	CDD:284209	62/182 (34%)
		Helicase_C_2	546..725	CDD:290046	66/184 (36%)
		HN_RTEL1	896..985	CDD:259826
CG11403	NP_569898.1	DinG	15..841	CDD:224120	217/866 (25%)
		DEXDc2	16..394	CDD:214693	101/389 (26%)
		Helicase_C_2	659..836	CDD:290046	67/186 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467042
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1199
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	67	1.000	Inparanoid score	I412
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11472
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.900