Protein Alignment Rtel1 and Ercc2

DIOPT Version :10

• Sequence 1: NP_572254.1
• Gene: Rtel1 / 31497
• FlyBaseID: FBgn0029798
• Length: 985
• Species: Drosophila melanogaster
• Sequence 2: NP_001166280.1
• Gene: Ercc2 / 308415
• RGDID: 1309109
• Length: 760
• Species: Rattus norvegicus
• Alignment Length: 874
• Identity: 229/874 - (26%)
• Similarity: 370/874 - (42%)
• Gaps: 211/874 - (24%)

  Fly     6 IAGIPVHFPFE-PYPVQRAYMEKVIHCLRDGTNGVLESPTGTGKTLSLLCSSLAWIRTRQSEHQK 69
            :.|:.|:||:: .||.|.:||.::...|....:||||.|:|||||:|||...:|:.|....|
  Rat     5 VDGLLVYFPYDYIYPEQFSYMLELKRTLDAKGHGVLEMPSGTGKTVSLLALIVAYQRAYPLE--- 66

  Fly    70 QMVKMEKADFSGLGGGAPGGDLSELAKTMGRANNWGVPKVIYASRTHSQLTQAMRELKR--TAYA 132
                                                |.|:||.|||..::.:.:.||::  :.|.
  Rat    67 ------------------------------------VTKLIYCSRTVPEIEKVIEELRKLLSFYE 95

  Fly   133 NMR-------SVVLGSRDQLCIHPEVMREQGNSNKTNMCKLRVHSKTCSFQMRVESRKDHP---- 186
            ...       .:.|.||..|||||||...:...:....|    ||.|.|: :|.:.::|..
  Rat    96 QQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKC----HSLTASY-VRAQYQQDASLPHC 155

  Fly   187 ------DLRG-----PT-IMDIEDLVKVGQRLKICPYFASRELVPQADITFMPYNYLLDPK---- 235
                  |..|     |. |.:::||..:|||...||||.:|..:..|::....|:||||||
  Rat   156 RFYEEFDTHGRQVPLPAGIYNLDDLKALGQRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADL 220

  Fly   236 -----ARKANKIELGNTIVILDEAHNIEKICEESASVQIK-------SSDVAMAIEDVTHIMQVF 288
                 ||||        :|:.||||||:.:|.:|.||.:.       .|::....:.|..|.:.
  Rat   221 VSKELARKA--------VVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKET- 276

  Fly   289 ASGESQDMAGDEPKDFTLDDLTLLKEMLLELEKAIDAIVVDNAVDGTTFPASMMYELLGKANFTY 353
                      ||.:  ..|:...|.|.|.|...|.:   .|..:.....|..::.|.:.
  Rat   277 ----------DEQR--LRDEYRRLVEGLREASAARE---TDAHLANPVLPDEVLQEAVP------ 320

  Fly   354 GNVAT---IVSLLDKLVQYLLVASQQMSIRKGGTFTLLSDLLTIVFANKEDV------MSKVYAS 409
            |::.|   .:..|.:|::|:....:...:.:......||.|...|...::.:      :..:..:
  Rat   321 GSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHT 385

  Fly   410 FKVHVLVEESKQGHGKQQGAKQQGGWLGKGTIAA--ATGLSKVAK-------------------I 453
            .::..|.:.|..                  |:.|  ||.:|..||                   |
  Rat   386 LEIADLADFSPL------------------TLLANFATLVSTYAKGFTIIIEPFDDRTPTITNPI 432

  Fly   454 INFWCFNPGFGMEQLLNTQVRSVILTSGTLAPLKPLIAELAIPVAQHLENPHIVDQSQVYV---- 514
            ::|.|.:....::.:.. :.:|||:|||||:||...              |.|:|...|.:
  Rat   433 LHFSCMDASLAIKPVFE-RFQSVIITSGTLSPLDIY--------------PKILDFHPVTMATFT 482

  Fly   515 ----------KIIGTGPDRQQLISNYANRDNPKYISSLGQTILNVARIVPDGLLVFFPSYPMLNK 569
                      .|||.|.|:..:.|.:..|::...|.:.|..:|.::.:||||::.||.||..:..
  Rat   483 MTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMES 547

  Fly   570 CVDAWQASGLWADISCKKPIFLEPRSKDQFTSTMEEFYQAIRDSKGAVFMAVCRGKVSEGLDFAD 634
            .|.:|...|:..:|...|.:|:|.:...:.:..:|::.:|..:.:||:.::|.|||||||:||..
  Rat   548 TVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVH 612

  Fly   635 RNGRAVIITGLPFPPLKDPKVILKRR--YL-EANRTRENQLLSGQEWYNLDATRAVNQAIGRVIR 696
            ..|||||:.|:|:  :.....|||.|  || :..:.|||..|:      .||.|...|.:||.||
  Rat   613 HYGRAVIMFGVPY--VYTQSRILKARLEYLRDQFQIRENDFLT------FDAMRHAAQCVGRAIR 669

  Fly   697 HRNDYGAILLCDSRFKDASQVQQLSKWIRGHLGDRPQCSPFGPIVRELRQFFKNAEANMKLPDER 761
            .:.|||.::..|.||..|.:..:|.:||:.||.|    |.....|.|..|..|.....|..|..|
  Rat   670 GKTDYGLMVFADKRFARADKRGKLPRWIQEHLTD----SNLNLTVDEGVQVAKYFLRQMAQPFHR 730

  Fly   762 ETDSPLETVCKTE---DEPLAAIPKVKRE 787
            |....|..:...:   :|.|..|.::.::
  Rat   731 EDQLGLSLLSLEQLQSEETLQRIEQIAQQ 759

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rtel1	NP_572254.1	rad3	10..742	CDD:273169	216/820 (26%)
		HN_RTEL1	896..985	CDD:259826
Ercc2	NP_001166280.1	rad3	7..708	CDD:273169	217/819 (26%)