DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4078 and Rtel1

DIOPT Version :9

Sequence 1:	NP_001259262.1	Gene:	CG4078 / 31497	FlyBaseID:	FBgn0029798	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	XP_006500696.1	Gene:	Rtel1 / 269400	MGIID:	2139369	Length:	1266	Species:	Mus musculus

Alignment Length:	1048	Identity:	402/1048 - (38%)
Similarity:	579/1048 - (55%)	Gaps:	152/1048 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPESLIAGIPVHFPFEPYPVQRAYMEKVIHCLRDGTNGVLESPTGTGKTLSLLCSSLAWIRTRQS 65
            ||..::.|:.|.|||:|||.|:.||.||:.||:...||:|||||||||||.||||:|||     .
Mouse     1 MPRVVLNGVTVDFPFQPYPCQQEYMTKVLECLQKKVNGILESPTGTGKTLCLLCSTLAW-----Q 60

  Fly    66 EHQKQMVKMEKADFSGLGGGAPGGDLSELAKTMGRANNWG---------------VPKVIYASRT 115
            :|.:..|...|.      .....|:|. .::|:   ::||               :||:||||||
Mouse    61 QHLRDAVSSLKI------AERVQGELF-ASRTL---SSWGSAAAASGDSIECYTDIPKIIYASRT 115

  Fly   116 HSQLTQAMRELKRTAYANMRSVVLGSRDQLCIHPEVMREQGNSNKTNMCKLRVHSKTCSFQMRVE 180
            ||||||.:|||:.||| ..:..|||||:||||||||.:::.|..:.::|:.:|.|::|.|...||
Mouse   116 HSQLTQVIRELRNTAY-RPKVCVLGSREQLCIHPEVKKQESNHMQISLCRKKVASRSCHFYNNVE 179

  Fly   181 SRKDHPDLRGPTIMDIEDLVKVGQRLKICPYFASRELVPQADITFMPYNYLLDPKARKANKIELG 245
            ::....||..| |:|||||||.|.:.|:|||:.||.:..||||.|||||||||.|:|||:.|:|.
Mouse   180 AKFLEQDLATP-ILDIEDLVKNGSKQKMCPYYLSRNMKQQADIIFMPYNYLLDAKSRKAHSIDLK 243

  Fly   246 NTIVILDEAHNIEKICEESASVQIKSSDVAMAIEDVTHIMQ----VFASGE-SQDMAGDEPK--- 302
            .|:||.|||||:|||||||||..:...|||..:|.:..:::    |...|| .|:...|...
Mouse   244 GTVVIFDEAHNVEKICEESASFDLTPRDVASGLEIINQVLEEQARVTQQGELQQEFIVDTSSSGL 308

  Fly   303 DFTLDDLTLLKEMLLELEKAIDAIVVDNAVDGTTFPASMMYELLGKANFTYGNVATIVSLLDKLV 367
            :..|:|:..||.:||.||:||||:.:.....|.|.|.|.::||..:|..|:.....|:..||:::
Mouse   309 NMELEDIAKLKMILLRLEEAIDAVQLPGDDRGVTKPGSYIFELFAEAQITFQTKGCILESLDQII 373

  Fly   368 QYLLVASQQMSIRKGGTFT------LLSDLLTIVFANKEDVMSK-------VYASFKVHVLVEES 419
            |:|        ..:.|.||      .|.|::.|||:......|.       :..|:|||:..|.|
Mouse   374 QHL--------AGRTGVFTNTAGLQKLMDIIQIVFSVDPPEGSPGSLVGLGISHSYKVHIHPETS 430

  Fly   420 KQGHGKQQGAKQQGGWLGKGTIAAATGLSKVAKIINFWCFNPGFGMEQLLNTQVRSVILTSGTLA 484
                 .::.||:...|       :.|...|..|::::|||:|...|.:|:...||::||||||||
Mouse   431 -----HRRAAKRSDAW-------STTASRKQGKVLSYWCFSPSQSMRELVCQGVRTLILTSGTLA 483

  Fly   485 PLKPLIAELAIPVAQHLENPHIVDQSQVYVKIIGTGPDRQQLISNYANRDNPKYISSLGQTILNV 549
            ||.....|:.||....||||||:|::|::|.|:..|||..||.|.|..|.:.:.:||||:.:.|:
Mouse   484 PLSSFALEMQIPFPVCLENPHIIDKNQLWVGIVPRGPDGVQLSSAYDKRFSEECLSSLGKALSNI 548

  Fly   550 ARIVPDGLLVFFPSYPMLNKCVDAWQASGLWADISCKKPIFLEPRSKDQFTSTMEEFYQAIRD-- 612
            ||:||.||||||||||::.|.::.||..||...:...||:|:|||:|..|:..::.:||.:..
Mouse   549 ARVVPHGLLVFFPSYPVMEKSLEFWQVQGLARKVEALKPLFVEPRNKGSFSEVIDAYYQQVASPA 613

  Fly   613 SKGAVFMAVCRGKVSEGLDFADRNGRAVIITGLPFPPLKDPKVILKRRYLEANRTRE---NQLLS 674
            |.||.|:||||||.||||||:|.|||.||:||||:||..||:|:||.::|:..|.|.   .|.||
Mouse   614 SNGATFLAVCRGKASEGLDFSDMNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMRGRSGVGGQCLS 678

  Fly   675 GQEWYNLDATRAVNQAIGRVIRHRNDYGAILLCDSRFKDASQVQQLSKWIRGHLGDRPQCSPFGP 739
            |||||...|:||||||||||||||:|||||.|||.||..|....||..|:|.:|   .....||.
Mouse   679 GQEWYQQQASRAVNQAIGRVIRHRHDYGAIFLCDHRFAYADARAQLPSWVRPYL---KVYDNFGH 740

  Fly   740 IVRELRQFFKNAEANMKLP-DERETDSPLETVCKTEDEPLAA--------------IPKVKREP- 788
            ::|::.|||:.|:..|.|| .:..|.|..|.....:|..|::              :|.::::|
Mouse   741 VIRDVAQFFRVAQKTMPLPVPQAVTSSVSEGEIALKDATLSSYSLSTRKAMSLDVHVPSLRQKPI 805

  Fly   789 GSNATFKSANESAIKVEMANSIKTWTPADYASA-------AG----HKLGGAAPNAMDFMSRLDS 842
            |..|...|.:....:.|.........|....:|       ||    ..||.:.|:.     |.:.
Mouse   806 GLPAAGDSESSLCGEYEQQTFSAQQRPMGLLAALEYNEQKAGASEEQALGSSTPSL-----RCEK 865

  Fly   843 NVSSIDFNCCTDSKSGSSGLVKIHKRERSSPTAPESSSQVTKKRYKLVENIKVEPSSSQAKEAPE 907
            .:|       |:.|.|                         :|:.:||.:.:...:.:||..|
Mouse   866 RLS-------TEQKGG-------------------------RKKVRLVNHPEEPMAGTQAGRA-- 896

  Fly   908 ERAAFLRELRSLVTQDQFRRFGKALLEYKNGTYESFQALMAILLDVLSA-PKVRYMLVGMRKYLK 971
              ..|:..::..::|..|..|.:||..||:.  :.|:||:|.|..:.:. ||...:|.|..::::
Mouse   897 --KMFMVAVKQALSQANFDTFTQALQHYKSS--DDFEALVASLTCLFAEDPKKHTLLKGFYQFVR 957

  Fly   972 NEHKDEFD 979
            ..||.:|:
Mouse   958 PHHKQQFE 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4078	NP_001259262.1	rad3	10..742	CDD:273169	342/772 (44%)
		DEAD_2	111..274	CDD:284209	92/162 (57%)
		Helicase_C_2	546..725	CDD:290046	103/183 (56%)
		HN_RTEL1	896..985	CDD:259826	23/85 (27%)
Rtel1	XP_006500696.1	rad3	10..743	CDD:273169	342/772 (44%)
		HN_RTEL1	877..976	CDD:259826	25/95 (26%)
		HN_RTEL1	1038..1126	CDD:259826
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848141
Domainoid	1	1.000	218	1.000	Domainoid score	I2659
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H13168
Inparanoid	1	1.050	646	1.000	Inparanoid score	I798
Isobase	1	0.950	-	0	Normalized mean entropy	S3049
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006111
OrthoInspector	1	1.000	-	-		oto92762
orthoMCL	1	0.900	-	-		OOG6_102317
Panther	1	1.100	-	-	LDO	PTHR11472
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3587
SonicParanoid	1	1.000	-	-		X4406
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.730