Protein Alignment Rtel1 and ERCC2

DIOPT Version :10

• Sequence 1: NP_572254.1
• Gene: Rtel1 / 31497
• FlyBaseID: FBgn0029798
• Length: 985
• Species: Drosophila melanogaster
• Sequence 2: NP_000391.1
• Gene: ERCC2 / 2068
• HGNCID: 3434
• Length: 760
• Species: Homo sapiens
• Alignment Length: 874
• Identity: 225/874 - (25%)
• Similarity: 366/874 - (41%)
• Gaps: 211/874 - (24%)

  Fly     6 IAGIPVHFPFE-PYPVQRAYMEKVIHCLRDGTNGVLESPTGTGKTLSLLCSSLAWIRTRQSEHQK 69
            :.|:.|:||:: .||.|.:||.::...|....:||||.|:|||||:|||...:|:.|....|
Human     5 VDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAYPLE--- 66

  Fly    70 QMVKMEKADFSGLGGGAPGGDLSELAKTMGRANNWGVPKVIYASRTHSQLTQAMRELKR--TAYA 132
                                                |.|:||.|||..::.:.:.||::  ..|.
Human    67 ------------------------------------VTKLIYCSRTVPEIEKVIEELRKLLNFYE 95

  Fly   133 NMR-------SVVLGSRDQLCIHPEVMREQGNSNKTNMCKLRVHSKTCSFQMRVESRKDHP---- 186
            ...       .:.|.||..|||||||...:...:....|    ||.|.|: :|.:.:.|..
Human    96 KQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKC----HSLTASY-VRAQYQHDTSLPHC 155

  Fly   187 ------DLRG-----PT-IMDIEDLVKVGQRLKICPYFASRELVPQADITFMPYNYLLDPK---- 235
                  |..|     |. |.:::||..:|:|...||||.:|..:..|::....|:||||||
Human   156 RFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADL 220

  Fly   236 -----ARKANKIELGNTIVILDEAHNIEKICEESASVQIK-------SSDVAMAIEDVTHIMQVF 288
                 ||||        :|:.||||||:.:|.:|.||.:.       ..::....:.|..|.:.
Human   221 VSKELARKA--------VVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKET- 276

  Fly   289 ASGESQDMAGDEPKDFTLDDLTLLKEMLLELEKAIDAIVVDNAVDGTTFPASMMYELLGKANFTY 353
                      ||.:  ..|:...|.|.|.|...|.:   .|..:.....|..::.|.:.
Human   277 ----------DEQR--LRDEYRRLVEGLREASAARE---TDAHLANPVLPDEVLQEAVP------ 320

  Fly   354 GNVAT---IVSLLDKLVQYLLVASQQMSIRKGGTFTLLSDLLTIVFANKEDV------MSKVYAS 409
            |::.|   .:..|.:|::|:....:...:.:......||.|...|...::.:      :..:..:
Human   321 GSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHT 385

  Fly   410 FKVHVLVEESKQGHGKQQGAKQQGGWLGKGTIAA--ATGLSKVAK-------------------I 453
            .::..|.:.|..                  |:.|  ||.:|..||                   |
Human   386 LEITDLADFSPL------------------TLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPI 432

  Fly   454 INFWCFNPGFGMEQLLNTQVRSVILTSGTLAPLKPLIAELAIPVAQHLENPHIVDQSQVYV---- 514
            ::|.|.:....::.:.. :.:|||:|||||:||...              |.|:|...|.:
Human   433 LHFSCMDASLAIKPVFE-RFQSVIITSGTLSPLDIY--------------PKILDFHPVTMATFT 482

  Fly   515 ----------KIIGTGPDRQQLISNYANRDNPKYISSLGQTILNVARIVPDGLLVFFPSYPMLNK 569
                      .|||.|.|:..:.|.:..|::...|.:.|..:|.::.:||||::.||.||..:..
Human   483 MTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMES 547

  Fly   570 CVDAWQASGLWADISCKKPIFLEPRSKDQFTSTMEEFYQAIRDSKGAVFMAVCRGKVSEGLDFAD 634
            .|.:|...|:..:|...|.:|:|.:...:.:..:|::.:|..:.:||:.::|.|||||||:||..
Human   548 TVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVH 612

  Fly   635 RNGRAVIITGLPFPPLKDPKVILKRR--YL-EANRTRENQLLSGQEWYNLDATRAVNQAIGRVIR 696
            ..|||||:.|:|:  :.....|||.|  || :..:.|||..|:      .||.|...|.:||.||
Human   613 HYGRAVIMFGVPY--VYTQSRILKARLEYLRDQFQIRENDFLT------FDAMRHAAQCVGRAIR 669

  Fly   697 HRNDYGAILLCDSRFKDASQVQQLSKWIRGHLGDRPQCSPFGPIVRELRQFFKNAEANMKLPDER 761
            .:.|||.::..|.||....:..:|.:||:.||.|    :.....|.|..|..|.....|..|..|
Human   670 GKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTD----ANLNLTVDEGVQVAKYFLRQMAQPFHR 730

  Fly   762 ETDSPLETVCKTE---DEPLAAIPKVKRE 787
            |....|..:...:   :|.|..|.::.::
Human   731 EDQLGLSLLSLEQLESEETLKRIEQIAQQ 759

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rtel1	NP_572254.1	rad3	10..742	CDD:273169	212/820 (26%)
		HN_RTEL1	896..985	CDD:259826
ERCC2	NP_000391.1	rad3	7..708	CDD:273169	213/819 (26%)
		DEAH box	234..237		2/2 (100%)
		Mediates interaction with MMS19	438..637		63/215 (29%)
		Nuclear localization signal. /evidence=ECO:0000255	682..695		3/12 (25%)