DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4078 and chl-1

DIOPT Version :9

Sequence 1:	NP_001259262.1	Gene:	CG4078 / 31497	FlyBaseID:	FBgn0029798	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_499295.2	Gene:	chl-1 / 176457	WormBaseID:	WBGene00010839	Length:	830	Species:	Caenorhabditis elegans

Alignment Length:	902	Identity:	240/902 - (26%)
Similarity:	356/902 - (39%)	Gaps:	236/902 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 FPFEPYPVQRAYMEKVIHCLRDGTNGVLESPTGTGKTLSLLCSSLAWIR-----------TRQSE 66
            |||:||.:|...|.::..|:.....|:.||||||||:||:|||::.|:.           ||..|
Worm     6 FPFQPYDIQLNLMREIRQCIEQRKIGIFESPTGTGKSLSVLCSTMTWLEAEELRISTDLSTRLGE 70

  Fly    67 -HQK-----------------------QMVKME-------------KADFSGLG-------GGAP 87
             |.|                       |.|:.|             :.|.:..|       ..||
Worm    71 VHTKITECDKITTADNWETAVREKMRAQDVETEILEQIQSRERLQSRIDQARRGMVEVSRKRKAP 135

  Fly    88 GGDLSELAKTMGRA------NN-----------------------WGVPKVIYASRTHSQLTQAM 123
            ..|..:..:....|      ||                       ....|:.|||||||||.|..
Worm   136 ARDTDQFLEPQDEAAPSEEYNNDEKSEKQRDSDFFDDVDEEEEKPLKCLKIFYASRTHSQLEQLA 200

  Fly   124 RELKRTAYANMRSVVLGSRDQLCIHPEV---------------MREQGNSNKTNMCKLR----VH 169
            .||.:|.: ..|.|...||..||::.||               :|:.|.|.|..:.||.    ..
Worm   201 EELAKTRF-QPRIVTCASRGTLCVNEEVKKLKLNHLINEKCMELRKNGMSEKEKVQKLEKGTTKK 264

  Fly   170 SKTCSFQMRVESRKDHPD-LRGPTIMDIEDLVKVGQRLKI---CPYFASRELVPQADITFMPYNY 230
            :|||:......:.....| :.|.....::..::|.::.|:   |||||:|:.|||..:..:||..
Worm   265 TKTCATSCEFYNSTQIEDVVNGVLSNKLKSTLEVSKQGKLSNGCPYFATRKSVPQCQLVLLPYQV 329

  Fly   231 LLDPKARKANKIELGNTIVILDEAHNIEKICEESASVQIKSSDVAMAIEDVTHIMQVFASGESQD 295
            ||....|||..|||.:.:::||||||:........|.:|.:..:.:|
Worm   330 LLHDGTRKAWGIELKDNVIVLDEAHNVLNTISSLYSAEISTKSLTLA------------------ 376

  Fly   296 MAGDEPKDFTLDDLTLLKEMLLELEKAIDAIVVDNAVDGTTFPASMMYELLGKANFTYGNVATIV 360
                         |.|::|                      :.|....:||.. |..|      :
Worm   377 -------------LRLIRE----------------------YNAHYKLKLLAH-NLLY------M 399

  Fly   361 SLLDKLVQYLLVASQQMSIRKGGTFTLLSDLLTIV---------FANKEDVMSKVYASFKVHVLV 416
            ..|:.|...:|:.....|.....|...|:..|.|:         :..|.|:..| :..|.:.:..
Worm   400 KQLESLTSKMLIFLNSQSKEDVMTMAQLARNLNILEINLFKLAEYMEKTDLCKK-FHGFYMRLQK 463

  Fly   417 EESKQ--------GHGKQQGAKQQGG-----------------WLGKGTIAAATGLSKVAKII-- 454
            ||.|:        |..|...||:...                 :..|..|.|.|...:..:||
Worm   464 EEIKKENEKPKLTGIQKLMAAKEAEPEPEAEPLPPPKPVPSPLFSLKSFIDALTNKCEDGRIIVE 528

  Fly   455 --------NFWCFNPGFGMEQLLNTQVRSVILTSGTLAPLKPLIAELA-----IPVAQHLENPHI 506
                    .|...||...:.::: |..|:.||..||:.|.:.|:..|:     ....:.....|:
Worm   529 KSATEAKFRFMLLNPADRLSEVV-TSARATILVGGTMEPAQLLVETLSRGSIGADSIRRFSCCHV 592

  Fly   507 VDQSQVYVKIIGTGPDRQQLISNYANRDNPKYISSLGQTILNVARIVPDGLLVFFPSYPMLNKCV 571
            :|.||:....:....|.:.....|..|.....:.||..:|..:...:|:|:::|.|||..|....
Worm   593 IDDSQLLAVTVERTVDGKPFQLTYQTRGADTTLRSLATSIQALIPHIPNGVVIFVPSYDFLFNFQ 657

  Fly   572 DAWQASGLWADISCKKPIFLEPRSKDQFTSTM-EEFYQAIRDSKGAVFMAVCRGKVSEGLDFADR 635
            ...:..|:...|..||.:|.|.|   |.||.: :.|.:|.:.||||:..||..||:|||::|.|.
Worm   658 KKMKEFGILKRIEEKKAVFTESR---QPTSDVWDRFSRAAKTSKGAILFAVVGGKMSEGINFCDE 719

  Fly   636 NGRAVIITGLPFPPLKDPKVILKRRYLEANRTRENQLLSGQEWYNLDATRAVNQAIGRVIRHRND 700
            .|||||:.|||:|.....::..:.::|:........||     |......||||||||.||||.|
Worm   720 LGRAVIVIGLPYPNKTSVELRERMKFLDTQMPNGGNLL-----YESLCMHAVNQAIGRAIRHRRD 779

  Fly   701 YGAILLCDSRFKDASQVQQLSKWIRGHLGDRPQCS-PFGPIVRELRQFFKNAEANMK 756
            |.|:.|.|.|:...|..::||.||    |||.|.. .||.|:|:.|.||   |||.|
Worm   780 YAAVYLFDDRYAKESTRRKLSTWI----GDRTQVKLGFGEIIRKTRSFF---EANSK 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4078	NP_001259262.1	rad3	10..742	CDD:273169	232/886 (26%)
		DEAD_2	111..274	CDD:284209	61/185 (33%)
		Helicase_C_2	546..725	CDD:290046	68/179 (38%)
		HN_RTEL1	896..985	CDD:259826
chl-1	NP_499295.2	P-loop_NTPase	2..387	CDD:304359	106/434 (24%)
		rad3	121..820	CDD:273169	201/773 (26%)
		Helicase_C_2	632..803	CDD:290046	67/178 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820