DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4078 and xpd-1

DIOPT Version :9

Sequence 1:	NP_001259262.1	Gene:	CG4078 / 31497	FlyBaseID:	FBgn0029798	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_001348650.1	Gene:	xpd-1 / 175190	WormBaseID:	WBGene00021752	Length:	755	Species:	Caenorhabditis elegans

Alignment Length:	813	Identity:	208/813 - (25%)
Similarity:	364/813 - (44%)	Gaps:	148/813 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IAGIPVHFPFE-PYPVQRAYMEKVIHCLRDGTNGVLESPTGTGKTLSLLCSSLAWIRTRQSEHQK 69
            |.|:.|.||:: .||.|..||::|...|....:|:||.|:|||||:|||...||:
Worm     5 IDGLKVLFPYDYVYPEQVLYMKEVKKALDARGHGLLEMPSGTGKTVSLLSLVLAY---------- 59

  Fly    70 QMVKM-EKADFSGLGGGAPGGDLSELAKTMGRANNWGVPKVIYASRTHSQLTQAMREL------- 126
             |:.. :|.|                             |::|.|||..::.:.:.|:
Worm    60 -MISYPDKLD-----------------------------KLVYCSRTIPEIEKCVEEMKVLYDYW 94

  Fly   127 -KRTAYANMR-SVVLGSRDQLCIH-PEVMREQGNSNKTNMCKLRVHS-----------KTCSFQM 177
             |.|.....: :|.:.:|..||:: |......||:..:...||...|           :.|.:..
Worm    95 EKETGQPVAKITVAMSARKNLCVNEPVAALRFGNTVDSACQKLTASSARQKRAEDPTLEACDYFE 159

  Fly   178 RVESRKDHPDLRGPTIMDIEDLVKVGQRLKICPYFASRELVPQADITFMPYNYLLDPK-ARKANK 241
            ..|: |..|...|  :.::|||..:|:..||||||.:|:.:.:|.|....|:|:|||| |...:|
Worm   160 NFEA-KSVPMQNG--VWNLEDLRSLGREKKICPYFTARQAINRAHIVVYSYHYILDPKIAELVSK 221

  Fly   242 IELGNTIVILDEAHNIEKICEESASVQI--KSSDVAM----AIEDVTHIMQVFASGESQDMAGDE 300
            .....::|:.||||||:.:|.||.||.|  |::|.|:    ::|.|.:.|:   |..|:.:..:.
Worm   222 DFSRKSVVVFDEAHNIDNVCIESMSVAISQKNADRALQELQSLEGVVNRMK---SSNSEKLQSEY 283

  Fly   301 PKDFTLDDLTLLKEML--LELEKAIDAIVVDNAVDGTTFPASMMYELLGKANFTYGNVAT---IV 360
            .|         |.|.|  .|.|:|     .|..:.....|..:::|.:.      ||:..   .:
Worm   284 DK---------LVEGLKRTERERA-----NDERLANPVLPDQILHEAVP------GNIRQANHFL 328

  Fly   361 SLLDKLVQYL--LVASQQMSIRKGGTFTLLSDLLTIVFANKEDVMSKVYASFKVHVLVEESKQGH 423
            ..|.:.|:|:  .:.:.|:.|.....|  :.|:|..:...::.:.   :.:.::..||:..:...
Worm   329 LFLKRFVEYIRHRLRTHQVLIESPAAF--MKDILDRMCIERKPMR---FCAERLSNLVKTLEITD 388

  Fly   424 GKQQGAKQQGGWLGKGTIAAATGLSKVAK--------IINFWCFNPGFGMEQLLNTQVRSVILTS 480
            .....|..|...|.......:.|.|.:.:        :|...|.:....:..:: ::.:|||:||
Worm   389 NGDVWALSQVTTLCTLVSTYSKGFSVIVEPQDGSQLAVITLSCHDASIAIRPVM-SRFQSVIITS 452

  Fly   481 GTLAPLK----------PLIAELAIPVAQHLENPHIVDQSQVYVKIIGTGPDRQQLISNYANRDN 535
            |||:||:          .:||...:.:|:...:|          .::..|.|:..:.|.:..|.:
Worm   453 GTLSPLEMYPKVLDFDPSVIASFTMTLARPCLSP----------LVVARGNDQVAMTSRFEQRAD 507

  Fly   536 PKYISSLGQTILNVARIVPDGLLVFFPSYPMLNKCVDAWQASGLWADISCKKPIFLEPRSKDQFT 600
            ...|.:.|..:|.:|.:||||::|||.||..:...:..|....:..::...|.:|:|.....:.:
Worm   508 VAVIRNYGNLVLEMASLVPDGMVVFFTSYLYMENVIGVWYEQHIIDELMKYKLLFIETNDALETS 572

  Fly   601 STMEEFYQAIRDSKGAVFMAVCRGKVSEGLDFADRNGRAVIITGLPFPPLKDPKVILKRRYL-EA 664
            :.:|::.:|....:|||..:|.|||||||:||:...||.||:.|:|:...:...:..:..|| :.
Worm   573 AALEKYVEACDSGRGAVLFSVARGKVSEGIDFSHHLGRCVIMLGIPYMYTESRVLRARLEYLRDQ 637

  Fly   665 NRTRENQLLSGQEWYNLDATRAVNQAIGRVIRHRNDYGAILLCDSRFKDASQVQQLSKWIRGHLG 729
            ...:||..|:      .||.|...|.:||.:|.:.|||.::..|.||....:..:|.:|::.:|
Worm   638 FGIKENDFLT------FDAMRHTAQCMGRALRSKTDYGLMVFADKRFSRNDKRGKLPRWMQEYL- 695

  Fly   730 DRPQCSPFGPIVRELRQFFKNAEANMKLPDERE 762
             .|.|:...  :.|..|..:.....|..|.|:|
Worm   696 -EPACTNLS--IDEAAQVARRWLTLMAQPFEKE 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4078	NP_001259262.1	rad3	10..742	CDD:273169	200/787 (25%)
		DEAD_2	111..274	CDD:284209	57/186 (31%)
		Helicase_C_2	546..725	CDD:290046	56/179 (31%)
		HN_RTEL1	896..985	CDD:259826
xpd-1	NP_001348650.1	rad3	7..702	CDD:273169	201/784 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820