DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4078 and dog-1

DIOPT Version :9

Sequence 1:	NP_001259262.1	Gene:	CG4078 / 31497	FlyBaseID:	FBgn0029798	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_493618.1	Gene:	dog-1 / 173370	WormBaseID:	WBGene00001049	Length:	983	Species:	Caenorhabditis elegans

Alignment Length:	924	Identity:	251/924 - (27%)
Similarity:	399/924 - (43%)	Gaps:	213/924 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LIAGIPVHFP--FEPYPVQRAYMEKVIHCLRDGTNGVLESPTGTGKTLSLLCSSLAWIRTRQSEH 67
            ::.|:||..|  ...|..|:..:.:::..|::..|.:.|||||:|||::||.|:.||::....|.
Worm    76 MMLGVPVRVPRGLSLYSTQKLMIVRILTALKNSQNVLGESPTGSGKTMALLASTCAWLKQYIDEK 140

  Fly    68 QKQMVKMEKADFSG---------LG---------------------------------------- 83
            ::...|.|...|||         :|
Worm   141 RESKEKCEIHGFSGKTQVVFTNDIGIPLESKVYEEPPEEEEFIEPVPVKNDKLFEAQWEHDFTPH 205

  Fly    84 --GGAPGGDLSELAKTMGRANNWGVP-----------KVIYASRTHSQLTQAMRELKRTAYAN-M 134
              |..|...|.|..:.:.:..    |           ::.|.:|||.|:.|.::|..|..||. :
Worm   206 TPGETPPVTLKEELEPVKKPE----PVETKCTCLPRVRIYYGTRTHKQIAQVVKEFSRLPYAKIL 266

  Fly   135 RSVVLGSRDQLCIHPEVMREQGNSNKTNMCK--LRVHSKTCSFQMRVESR-------KDHPDLRG 190
            :..:|.||:|.||:|...:   :::.:..||  ...||..|||:..::.|       :||.:..|
Worm   267 KHTILASREQSCINPAARK---HADISQYCKEVNSAHSIGCSFKSAMKPRFEKALPLRDHLERNG 328

  Fly   191 PTIMDIEDLVKVGQRL-----KICPYFASRELVPQ-ADITFMPYNYLLDPKARKANKIELGNTIV 249
            ..:.|:|   |:.:.|     ::||||::..::.| |||.|.|::||:||..|.::.:::.|:||
Worm   329 TVVFDME---KIVETLAISYPQLCPYFSTNRILTQDADIIFCPFSYLVDPLIRNSSDVQIRNSIV 390

  Fly   250 ILDEAHNIEKICEESASVQIKSSDVAMAIEDVTHIMQVFASGESQDMAGDEPKDFTLDD------ 308
            |||||||||..|.|:||......::..:|..:.  ::..|.....|..|.|.|...:.|
Worm   391 ILDEAHNIEDTCREAASFSFTEKELDDSILSLR--IKRKAVDTELDKTGIEEKLLHIPDREVHLK 453

  Fly   309 -----LTLLKEMLLELEKAIDAIVVD------NAVDG----TTFPASMMYELLGKAN----FT-- 352
                 |..|:.::||:.:.|..:..:      ...||    |...|::...|....|    ||
Worm   454 EFRGHLLYLEHLILEMLRWIRQVSTEAKTPARGGQDGVKTCTISSANLFTSLTDPENGVDLFTPP 518

  Fly   353 ----YGNVATIVSLLDK----LVQYL---------------------LVASQQMS---------- 378
                :..||...|.:.|    .:||.                     ...:||..
Worm   519 LTPKHAAVAASFSAITKHNEPEMQYFDAFKPSSTAIVCIEKWLYFQSYFGNQQYQSTYRLNISIE 583

  Fly   379 -IRKGGTF--TLLSDL-LTIVFANKEDVMSKVYASFKVHVLVEESKQGHGKQQGAKQQGGWLGKG 439
             |.:.|.|  |..:|: ::..|.|.....::             |..|....| .|::..||..
Worm   584 PINQNGRFNHTFDADVSMSTSFGNPRPTTTR-------------SSAGPRNMQ-YKEENAWLAD- 633

  Fly   440 TIAAATG---------------LSKVAK-IINFWCFNPGFGMEQLLNTQVRSVILTSGTLAPLKP 488
              |||.|               :|:..| .|:.||.:|........| :.||::|.||||.|:..
Worm   634 --AAADGDDWKDPSMSETGHKPISEGCKTTISLWCMSPALSFFDAFN-ETRSIVLASGTLCPMDT 695

  Fly   489 LIAELAIPVAQHLENPHIVDQSQVYVKIIGTGPDRQQLISNYANRDNPK--YISSLGQTILNVAR 551
            |..||.:...|.:|...::::..::..::..||...::...|.|..:|:  :...||..|..|..
Worm   696 LKTELGMEFKQQVEGDQVINKDNIFAAVLPIGPFGNRIQCTYRNTSDPESSFYCELGAIIKYVCS 760

  Fly   552 IVPDGLLVFFPSYPMLNKCVDAWQASGLWADISCKKPIFLEPRSKDQFTSTMEEFYQAIRDS--- 613
            .||.|:|.|.|||.:|::.......:.....|..||.:..|||...:.||.|::|..||.|.
Worm   761 NVPAGILCFLPSYRVLDQLKQCMIRNSTMRQIEMKKVVLYEPRRSSELTSVMDQFDAAIFDPSRF 825

  Fly   614 ----KGAVFMAVCRGKVSEGLDFADRNGRAVIITGLPFPPLKDPKVILKRRYLEANRTRENQLLS 674
                .|::..||.|||||||:||||...|.||..|:|:|...|.:|..|:.|.:.| ::|..:|:
Worm   826 GANINGSLMFAVFRGKVSEGIDFADDRARVVISVGIPYPNAMDDQVNAKKLYNDQN-SKEKGILT 889

  Fly   675 GQEWYNLDATRAVNQAIGRVIRHRNDYGAILLCDSRFK-------DASQVQQLSKWIRGHLGDRP 732
            |.|||...|.||:|||:||.:||:||:||:|:.|.|.:       ..:...::|||||..|...|
Worm   890 GDEWYTTQAYRALNQALGRCLRHKNDWGAMLMIDERLERQTGNLVGGASSARVSKWIRAQLKSYP 954

  Fly   733 QCSPFGPIVRELRQ 746
            ....|....||..|
Worm   955 SFKEFNANFREFIQ 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4078	NP_001259262.1	rad3	10..742	CDD:273169	247/913 (27%)
		DEAD_2	111..274	CDD:284209	63/178 (35%)
		Helicase_C_2	546..725	CDD:290046	75/192 (39%)
		HN_RTEL1	896..985	CDD:259826
dog-1	NP_493618.1	rad3	238..947	CDD:273169	210/735 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53562
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3587
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860