DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4078 and rtel-1

DIOPT Version :9

Sequence 1:	NP_001259262.1	Gene:	CG4078 / 31497	FlyBaseID:	FBgn0029798	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_492769.1	Gene:	rtel-1 / 172946	WormBaseID:	WBGene00009124	Length:	994	Species:	Caenorhabditis elegans

Alignment Length:	1080	Identity:	306/1080 - (28%)
Similarity:	495/1080 - (45%)	Gaps:	223/1080 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IPVHFPFEPYPVQRAYMEKVIHCLRDGTNGVLESPTGTGKTLSLLCSSLAWIRTRQSEHQKQMVK 73
            :.|.||||||..||.:|:.|:..|....:..||||||||||||||||:|||:     :.||:...
Worm    17 LSVKFPFEPYECQRIFMKNVVDVLDRKLDAALESPTGTGKTLSLLCSTLAWV-----QRQKETKP 76

  Fly    74 MEKADF--SGLGGGAPGGDLSELAKTMGRANNWGVPKVIYASRTHSQLTQAMRELKRTAYANMRS 136
            ::.|.:  ||.||.         .||..:..:..||.:.|||||||||.|.:.||.||.|..:::
Worm    77 LDFATWQTSGAGGA---------EKTDEKLKSAYVPTIFYASRTHSQLEQVVHELNRTEYKWVKT 132

  Fly   137 VVLGSRDQLCIHPEVMREQGNSNKTNMCKLRVHSKTCSFQMRVE---SRKDHPDLRGPTIMDIED 198
            .:||||:..||:.:|.:.:.::.:.::|:..|..:.|.:..:.:   :.|....|.....|||||
Worm   133 TILGSREHFCINQKVKKIKESNRQAHVCRGLVSKRACHYYNKFDACTTDKMTEFLDKGEAMDIED 197

  Fly   199 LVKVGQRLKICPYFASRELVPQADITFMPYNYLLDPKARKANKIELGNTIVILDEAHNIEKICEE 263
            .||:|.:..:||||.||:....|::..:||||::|||.|:..|::|.|:|||.|||||:|.|||.
Worm   198 FVKLGTQNSLCPYFMSRQRSETAELILLPYNYIIDPKMRRRYKLDLKNSIVIFDEAHNLESICES 262

  Fly   264 SASVQIKSSDVAMAIEDVTHIMQVFASGESQDMA---------GDEPKDFT--------LDDLTL 311
            :||.::.|:.:|:.||::..::.:....|....:         |....|.|        .:||..
Worm   263 NASAELTSTSIALCIEELKKVLALLVDEEETARSEADAETGAFGSAKIDLTKKLIENLRTEDLMT 327

  Fly   312 LKEMLLELEKAIDAIVVDN------AVDGTTFPASMMYELLGKANFTYGNVATIVSLLDKLVQYL 370
            :.|.:..||:.:|.:...:      .:.|......::.|.|.||.|...:|..:|.:|...:.||
Worm   328 VLEKIFSLEEEMDKLFGSSQLKSVPPLSGKASDGEILLETLAKAGFDANSVERLVDVLRDAISYL 392

  Fly   371 LVASQQMSI-RKGGTFTLLSD-LLTIVFANKEDVMSKVYASFKVHVLVEESKQGHGKQQGAKQQG 433
            |..:::::: .||.....::| ||:|...:.:||.:.|
Worm   393 LSKNEEVALTEKGDGMEKVADFLLSIYSTHAQDVAAAV--------------------------- 430

  Fly   434 GWLGKGTIAAATGL--SKVAK---------------IINFWCFNPGFGMEQLLNTQVRSVILTSG 481
               |:.|:.....:  ..||:               .|.::||.....|..|....||:|:|.||
Worm   431 ---GEETVKLVDRVDPKTVARNCKLYIQKDKDNEKLTIKYFCFQASISMRMLKMRGVRNVLLASG 492

  Fly   482 TLAPLKPLIAELAIPVAQHLENPHIVDQSQVYVKIIGTGPDRQQLISNYANRDNPKYISSLGQTI 546
            ||:|::.....:.:.....|||.|.:.|..|...|:..| .|..|..::.||.|..|::.:.:.:
Worm   493 TLSPIQAFTYNMGLNFGAILENEHALKQVPVLTSIVTRG-KRGGLAGSFQNRKNLDYVTGVAEAL 556

  Fly   547 LNVARIVPDGLLVFFPSYPMLNKCVDAWQAS--------GLWADISCKKPIFLEPRSKDQFTSTM 603
            |.|..::|.|:|:||.||..:::.|..|:.:        ..|..:...|.:.:|||:|::..:..
Worm   557 LRVMEVIPQGILIFFSSYSQMDELVATWKTTKWSSNSNESFWEKMEKTKRVVVEPRAKEELAAIR 621

  Fly   604 EEFYQAIRDSKGAVFMAVCRGKVSEGLDFADRNGRAVIITGLPFPPLKDPKVILKRRYLE---AN 665
            ..:.|.:.:..||..:||||||||||:||.|...|||||.|:|:||:.|.:|:||:.||:   ..
Worm   622 LRYTQGVSEQHGAALLAVCRGKVSEGIDFCDAESRAVIIIGIPYPPIHDERVVLKKMYLDDLMGR 686

  Fly   666 RTRENQLLSGQEWYNLDATRAVNQAIGRVIRHRNDYGAILLCDSRFKDASQVQQLSKWI------ 724
            :..:::..|.|:||.::|.||||||||||:||::|:|.::|.|:|:..| :.:...||:
Worm   687 KDTKSERQSSQDWYQMEAFRAVNQAIGRVLRHKDDFGTVVLMDTRYASA-KPEMFPKWLRNTISR 750

  Fly   725 ----------------RGHLGDR----------PQCSPFGPIVRELRQFFKN------------- 750
                            ||||.:.          .||..|    |:::|...:
Worm   751 SDTDGCALKTSRFFKERGHLIENSKTEYIKKQAKQCKSF----RQVKQTAASDSKDDIIEITLED 811

  Fly   751 --AEANMKLPDERETDSPLETVCKTEDEPLAAIPKVKREPGSNATFKSANESAIKVEMANSIKTW 813
              :.||||| :::|.         |:..|...||..     |:......||..:|      ||.|
Worm   812 MFSPANMKL-EKKEI---------TKLRPPQLIPST-----SSVFSLPTNEDELK------IKKW 855

  Fly   814 TPADYASAAGHKLGGAAPNAMDFMSR--LDSNVSSIDFNCCTDSKSGSSGLVKIHKRERSSPTAP 876
                           ...|.:..:|.  |:||....                ||.....|:.|..
Worm   856 ---------------EQENDIQCLSSIPLESNKRKF----------------KIETPGPSTSTLT 889

  Fly   877 ESSSQVTKKRYKLVENIKVEPSSSQAKEAPEERAAFLRELRSLVTQDQFRRFGKALLEYKNGTY- 940
            :.|....||:..|:....:.....:|.|.|..      ||...::.|..::|...|..||..:.
Worm   890 QKSEPPKKKKILLLTRNTLPDEYQKAIEIPTS------ELLKDMSDDNKKQFATTLRSYKAESIR 948

  Fly   941 --ESFQALMAILLDVLSAPKVRYMLVGMRKYLKNEHKDEF 978
              |.||....|.:     |....:.:.....|::|.|.::
Worm   949 WDEVFQRFRPIFV-----PHKADLFIACSNVLRSEDKMKY 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4078	NP_001259262.1	rad3	10..742	CDD:273169	256/821 (31%)
		DEAD_2	111..274	CDD:284209	68/165 (41%)
		Helicase_C_2	546..725	CDD:290046	73/211 (35%)
		HN_RTEL1	896..985	CDD:259826	18/86 (21%)
rtel-1	NP_492769.1	rad3	16..761	CDD:273169	249/789 (32%)
		DEXDc2	17..293	CDD:214693	114/289 (39%)
		Helicase_C_2	556..747	CDD:290046	73/191 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165689
Domainoid	1	1.000	163	1.000	Domainoid score	I2414
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H13168
Inparanoid	1	1.050	421	1.000	Inparanoid score	I1004
Isobase	1	0.950	-	0	Normalized mean entropy	S3049
OMA	1	1.010	-	-		QHG53562
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	1	1.000	-	-		FOG0006111
OrthoInspector	1	1.000	-	-		oto19193
orthoMCL	1	0.900	-	-		OOG6_102317
Panther	1	1.100	-	-	LDO	PTHR11472
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3587
SonicParanoid	1	1.000	-	-		X4406
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.790