DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4078 and DDX11

DIOPT Version :9

Sequence 1:	NP_001259262.1	Gene:	CG4078 / 31497	FlyBaseID:	FBgn0029798	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	XP_016874407.1	Gene:	DDX11 / 1663	HGNCID:	2736	Length:	1091	Species:	Homo sapiens

Alignment Length:	905	Identity:	197/905 - (21%)
Similarity:	340/905 - (37%)	Gaps:	283/905 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IAGIPVHFPFEPYPVQRAYMEKVIHCLRDGTNGVLESPTGTGKTLSLLCSSLAWIRTRQSEHQKQ 70
            :..|...|||.||.:|..:|.::...|..|..|:.||||||||:|||:|.:|:|:|..:.:.:::
Human    44 VGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALSWLRDFEQKKREE 108

  Fly    71 MVKM----------EKAD----FSGLGGGA----PGGD--------------------------- 90
            ..::          ||.:    .|...|.|    |.|:
Human   109 EARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVDRLKAEQARR 173

  Fly    91 -----------------------------------LS-ELAKTMGRANNW--------------- 104
                                               || |:.:|...|...
Human   174 KQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERLEQLESGEEELVLAEY 238

  Fly   105 ----------------------GVPKVIYASRTHSQLTQAMRELKRTAYA-NMRSVVLGSRDQLC 146
                                  .:.|:.|.|||||||.|.:.|:|::.:. ::|.|.||||..||
Human   239 ESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLC 303

  Fly   147 IHPEVMREQG-----NSNKTNMCKLRVHSKTCSFQMRVESRKDHPDLRGP--------------- 191
            ::.:| :..|     |....:|.:.|...|..:.:.:.:.|:.......|
Human   304 VNEDV-KSLGSVQLINDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEAL 367

  Fly   192 -TIMDIEDLVKVGQRLKICPYFASRELVPQADITFMPYNYLLDPKARKANKIELGNTIVILDEAH 255
             .:.|:|.|:.:|:..:.|||:.||..:|.|.:..:||..||....|:|..|.|.:.:||:||||
Human   368 AEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAH 432

  Fly   256 NIEKICEESASVQIKSSDVAMAIEDVTHIMQVFASGESQDMAGDEPKDFTLDDLTLLKEMLLELE 320
            |:........||::..|.:..|...:...::.:.            |.....:|..||::|..||
Human   433 NLIDTITGMHSVEVSGSQLCQAHSQLLQYVERYG------------KRLKAKNLMYLKQILYLLE 485

  Fly   321 KAIDAIVVDN----------AVDGTTFPASMMYELLGKANFTYGNVATIVSLLDKLVQYLLVASQ 375
            |.: |::..|          :..||        ||....:|.:.:....::|. |:.:|   ..:
Human   486 KFV-AVLGGNIKQNPNTQSLSQTGT--------ELKTINDFLFQSQIDNINLF-KVQRY---CEK 537

  Fly   376 QMSIRKGGTFTLLSDLLTIVFANKEDVMSKVYASFKVHVLVEESKQGHGKQQGA----KQQGGWL 436
            .|..||...||   :....||:::|......:..|.      :|.|....:..|    :.|...|
Human   538 SMISRKLFGFT---ERYGAVFSSREQPKLAGFQQFL------QSLQPRTTEALAAPADESQASTL 593

  Fly   437 G--------KGTIAAATGLSKVAKII------------NFWCFNPGFGMEQLLNTQVRSVILTSG 481
            .        :|.:||.|..::..::|            .|...||.....|::. :.|:|::..|
Human   594 RPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLLNPAVHFAQVVK-ECRAVVIAGG 657

  Fly   482 TLAPL-----KPLIAELAIP--------------------------------------------- 496
            |:.|.     .||:.....|
Human   658 TMQPAAGAVETPLLLHSVAPGSHVSQRKLFCGFKLKEKNHDSTFKRCLTSGSSCWPVPGWKLSAW 722

  Fly   497 ------VAQHLE----------NPHIVDQSQVYVKIIGTGPDRQQLISNYANRDNPKYISSLGQT 545
                  :|.||.          ..|::....:...:|.:|...|.|...:..|:.|:.:..:|:.
Human   723 WSFPVCLAAHLHLQFSAPPWLLPGHVIPPDNILPLVICSGISNQPLEFTFQKRELPQMMDEVGRI 787

  Fly   546 ILNVARIVPDGLLVFFPSYPMLNKCVDAWQASGLWADISCKKPIFLEPRSKDQFTSTMEEFYQAI 610
            :.|:..:||.|::.|||||..|.:....|:..||...::.:|.||.||:|..|....:..:.:.|
Human   788 LCNLCGVVPGGVVCFFPSYEYLRQVHAHWEKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRCI 852

  Fly   611 R-------DSKGAVFMAVCRGKVSEGLDFADRNGRAVIITGLPFPPLKDPKVILKRRYLE 663
            :       ...||:.::|..||:|||::|:|..||.|::.|:|||.::..::..|..||:
Human   853 QACGQERGQVTGALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLD 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4078	NP_001259262.1	rad3	10..742	CDD:273169	196/901 (22%)
		DEAD_2	111..274	CDD:284209	56/184 (30%)
		Helicase_C_2	546..725	CDD:290046	41/125 (33%)
		HN_RTEL1	896..985	CDD:259826
DDX11	XP_016874407.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820