Protein Alignment Rtel1 and DDX11

DIOPT Version :10

• Sequence 1: NP_572254.1
• Gene: Rtel1 / 31497
• FlyBaseID: FBgn0029798
• Length: 985
• Species: Drosophila melanogaster
• Sequence 2: XP_016874408.1
• Gene: DDX11 / 1663
• HGNCID: 2736
• Length: 1091
• Species: Homo sapiens
• Alignment Length: 905
• Identity: 197/905 - (21%)
• Similarity: 340/905 - (37%)
• Gaps: 283/905 - (31%)

  Fly     6 IAGIPVHFPFEPYPVQRAYMEKVIHCLRDGTNGVLESPTGTGKTLSLLCSSLAWIRTRQSEHQKQ 70
            :..|...|||.||.:|..:|.::...|..|..|:.||||||||:|||:|.:|:|:|..:.:.:::
Human    44 VGAIHFPFPFTPYSIQEDFMAELYRVLEAGKIGIFESPTGTGKSLSLICGALSWLRDFEQKKREE 108

  Fly    71 MVKM----------EKAD----FSGLGGGA----PGGD--------------------------- 90
            ..::          ||.:    .|...|.|    |.|:
Human   109 EARLLETGTGPLHDEKDESLCLSSSCEGAAGTPRPAGEPAWVTQFVQKKEERDLVDRLKAEQARR 173

  Fly    91 -----------------------------------LS-ELAKTMGRANNW--------------- 104
                                               || |:.:|...|...
Human   174 KQREERLQQLQHRVQLKYAAKRLRQEEEERENLLRLSREMLETGPEAERLEQLESGEEELVLAEY 238

  Fly   105 ----------------------GVPKVIYASRTHSQLTQAMRELKRTAYA-NMRSVVLGSRDQLC 146
                                  .:.|:.|.|||||||.|.:.|:|::.:. ::|.|.||||..||
Human   239 ESDEEKKVASRVDEDEDDLEEEHITKIYYCSRTHSQLAQFVHEVKKSPFGKDVRLVSLGSRQNLC 303

  Fly   147 IHPEVMREQG-----NSNKTNMCKLRVHSKTCSFQMRVESRKDHPDLRGP--------------- 191
            ::.:| :..|     |....:|.:.|...|..:.:.:.:.|:.......|
Human   304 VNEDV-KSLGSVQLINDRCVDMQRSRHEKKKGAEEEKPKRRRQEKQAACPFYNHEQMGLLRDEAL 367

  Fly   192 -TIMDIEDLVKVGQRLKICPYFASRELVPQADITFMPYNYLLDPKARKANKIELGNTIVILDEAH 255
             .:.|:|.|:.:|:..:.|||:.||..:|.|.:..:||..||....|:|..|.|.:.:||:||||
Human   368 AEVKDMEQLLALGKEARACPYYGSRLAIPAAQLVVLPYQMLLHAATRQAAGIRLQDQVVIIDEAH 432

  Fly   256 NIEKICEESASVQIKSSDVAMAIEDVTHIMQVFASGESQDMAGDEPKDFTLDDLTLLKEMLLELE 320
            |:........||::..|.:..|...:...::.:.            |.....:|..||::|..||
Human   433 NLIDTITGMHSVEVSGSQLCQAHSQLLQYVERYG------------KRLKAKNLMYLKQILYLLE 485

  Fly   321 KAIDAIVVDN----------AVDGTTFPASMMYELLGKANFTYGNVATIVSLLDKLVQYLLVASQ 375
            |.: |::..|          :..||        ||....:|.:.:....::|. |:.:|   ..:
Human   486 KFV-AVLGGNIKQNPNTQSLSQTGT--------ELKTINDFLFQSQIDNINLF-KVQRY---CEK 537

  Fly   376 QMSIRKGGTFTLLSDLLTIVFANKEDVMSKVYASFKVHVLVEESKQGHGKQQGA----KQQGGWL 436
            .|..||...||   :....||:::|......:..|.      :|.|....:..|    :.|...|
Human   538 SMISRKLFGFT---ERYGAVFSSREQPKLAGFQQFL------QSLQPRTTEALAAPADESQASTL 593

  Fly   437 G--------KGTIAAATGLSKVAKII------------NFWCFNPGFGMEQLLNTQVRSVILTSG 481
            .        :|.:||.|..::..::|            .|...||.....|::. :.|:|::..|
Human   594 RPASPLMHIQGFLAALTTANQDGRVILSRQGSLSQSTLKFLLLNPAVHFAQVVK-ECRAVVIAGG 657

  Fly   482 TLAPL-----KPLIAELAIP--------------------------------------------- 496
            |:.|.     .||:.....|
Human   658 TMQPAAGAVETPLLLHSVAPGSHVSQRKLFCGFKLKEKNHDSTFKRCLTSGSSCWPVPGWKLSAW 722

  Fly   497 ------VAQHLE----------NPHIVDQSQVYVKIIGTGPDRQQLISNYANRDNPKYISSLGQT 545
                  :|.||.          ..|::....:...:|.:|...|.|...:..|:.|:.:..:|:.
Human   723 WSFPVCLAAHLHLQFSAPPWLLPGHVIPPDNILPLVICSGISNQPLEFTFQKRELPQMMDEVGRI 787

  Fly   546 ILNVARIVPDGLLVFFPSYPMLNKCVDAWQASGLWADISCKKPIFLEPRSKDQFTSTMEEFYQAI 610
            :.|:..:||.|::.|||||..|.:....|:..||...::.:|.||.||:|..|....:..:.:.|
Human   788 LCNLCGVVPGGVVCFFPSYEYLRQVHAHWEKGGLLGRLAARKKIFQEPKSAHQVEQVLLAYSRCI 852

  Fly   611 R-------DSKGAVFMAVCRGKVSEGLDFADRNGRAVIITGLPFPPLKDPKVILKRRYLE 663
            :       ...||:.::|..||:|||::|:|..||.|::.|:|||.::..::..|..||:
Human   853 QACGQERGQVTGALLLSVVGGKMSEGINFSDNLGRCVVMVGMPFPNIRSAELQEKMAYLD 912

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rtel1	NP_572254.1	rad3	10..742	CDD:273169	196/901 (22%)
		HN_RTEL1	896..985	CDD:259826
DDX11	XP_016874408.1	rad3	263..918	CDD:273169	159/686 (23%)