DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4078 and Ercc2

DIOPT Version :9

Sequence 1:	NP_001259262.1	Gene:	CG4078 / 31497	FlyBaseID:	FBgn0029798	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	NP_031975.2	Gene:	Ercc2 / 13871	MGIID:	95413	Length:	760	Species:	Mus musculus

Alignment Length:	874	Identity:	228/874 - (26%)
Similarity:	371/874 - (42%)	Gaps:	211/874 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IAGIPVHFPFE-PYPVQRAYMEKVIHCLRDGTNGVLESPTGTGKTLSLLCSSLAWIRTRQSEHQK 69
            :.|:.|:||:: .||.|.:||.::...|....:||||.|:|||||:|||...:|:.|....|
Mouse     5 VDGLLVYFPYDYIYPEQFSYMLELKRTLDAKGHGVLEMPSGTGKTVSLLALIVAYQRAYPLE--- 66

  Fly    70 QMVKMEKADFSGLGGGAPGGDLSELAKTMGRANNWGVPKVIYASRTHSQLTQAMRELKR--TAYA 132
                                                |.|:||.|||..::.:.:.||::  :.|.
Mouse    67 ------------------------------------VTKLIYCSRTVPEIEKVIEELRKLLSFYE 95

  Fly   133 NMR-------SVVLGSRDQLCIHPEVMREQGNSNKTNMCKLRVHSKTCSFQMRVESRKDHP---- 186
            ...       .:.|.||..|||||||...:...:....|    ||.|.|: :|.:.::|..
Mouse    96 QQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKC----HSLTASY-VRAQYQQDASLPHC 155

  Fly   187 ------DLRG-----PT-IMDIEDLVKVGQRLKICPYFASRELVPQADITFMPYNYLLDPK---- 235
                  |:.|     |. |.:::||..:|||...||||.:|..:..|::....|:||||||
Mouse   156 RFYEEFDIHGRQMPLPAGIYNLDDLKALGQRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADL 220

  Fly   236 -----ARKANKIELGNTIVILDEAHNIEKICEESASVQIK-------SSDVAMAIEDVTHIMQVF 288
                 ||||        :|:.||||||:.:|.:|.||.:.       .|::....:.|..|.:.
Mouse   221 VSKELARKA--------VVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKET- 276

  Fly   289 ASGESQDMAGDEPKDFTLDDLTLLKEMLLELEKAIDAIVVDNAVDGTTFPASMMYELLGKANFTY 353
                      ||.:  ..|:...|.|.|.|...|.:   .|..:.....|..::.|.:.
Mouse   277 ----------DEQR--LRDEYRRLVEGLREASVARE---TDAHLANPVLPDEVLQEAVP------ 320

  Fly   354 GNVAT---IVSLLDKLVQYLLVASQQMSIRKGGTFTLLSDLLTIVFANKEDV------MSKVYAS 409
            |::.|   .:..|.:|::|:....:...:.:......||.|...|...::.:      :..:..:
Mouse   321 GSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHT 385

  Fly   410 FKVHVLVEESKQGHGKQQGAKQQGGWLGKGTIAA--ATGLSKVAK-------------------I 453
            .::..|.:.|..                  |:.|  ||.:|..||                   :
Mouse   386 LEIADLADFSPL------------------TLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPV 432

  Fly   454 INFWCFNPGFGMEQLLNTQVRSVILTSGTLAPLKPLIAELAIPVAQHLENPHIVDQSQVYV---- 514
            ::|.|.:....::.:.. :.:|||:|||||:||...              |.|:|...|.:
Mouse   433 LHFSCMDASLAIKPVFE-RFQSVIITSGTLSPLDIY--------------PKILDFHPVTMATFT 482

  Fly   515 ----------KIIGTGPDRQQLISNYANRDNPKYISSLGQTILNVARIVPDGLLVFFPSYPMLNK 569
                      .|||.|.|:..:.|.:..|::...|.:.|..:|.::.:||||::.||.||..:..
Mouse   483 MTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMES 547

  Fly   570 CVDAWQASGLWADISCKKPIFLEPRSKDQFTSTMEEFYQAIRDSKGAVFMAVCRGKVSEGLDFAD 634
            .|.:|...|:..:|...|.:|:|.:...:.:..:|::.:|..:.:||:.::|.|||||||:||..
Mouse   548 TVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVH 612

  Fly   635 RNGRAVIITGLPFPPLKDPKVILKRR--YL-EANRTRENQLLSGQEWYNLDATRAVNQAIGRVIR 696
            ..|||||:.|:|:  :.....|||.|  || :..:.|||..|:      .||.|...|.:||.||
Mouse   613 HYGRAVIMFGVPY--VYTQSRILKARLEYLRDQFQIRENDFLT------FDAMRHAAQCVGRAIR 669

  Fly   697 HRNDYGAILLCDSRFKDASQVQQLSKWIRGHLGDRPQCSPFGPIVRELRQFFKNAEANMKLPDER 761
            .:.|||.::..|.||..|.:..:|.:||:.||.|    |.....|.|..|..|.....|..|..|
Mouse   670 GKTDYGLMVFADKRFARADKRGKLPRWIQEHLTD----SNLNLTVDEGVQVAKYFLRQMAQPFHR 730

  Fly   762 ETDSPLETVCKTE---DEPLAAIPKVKRE 787
            |....|..:...:   :|.|..|.::.::
Mouse   731 EDQLGLSLLSLEQLQSEETLQRIEQIAQQ 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4078	NP_001259262.1	rad3	10..742	CDD:273169	215/820 (26%)
		DEAD_2	111..274	CDD:284209	62/203 (31%)
		Helicase_C_2	546..725	CDD:290046	64/181 (35%)
		HN_RTEL1	896..985	CDD:259826
Ercc2	NP_031975.2	rad3	7..708	CDD:273169	216/819 (26%)
		DEXDc2	8..280	CDD:214693	94/334 (28%)
		DEAH box	234..237		2/2 (100%)
		HBB	272..413	CDD:284245	29/180 (16%)
		Mediates interaction with MMS19. /evidence=ECO:0000250	438..637		63/215 (29%)
		HELICc2	542..686	CDD:214694	53/151 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820