Protein Alignment Rtel1 and brip1

DIOPT Version :10

• Sequence 1: NP_572254.1
• Gene: Rtel1 / 31497
• FlyBaseID: FBgn0029798
• Length: 985
• Species: Drosophila melanogaster
• Sequence 2: XP_002933884.1
• Gene: brip1 / 100489959
• XenbaseID: XB-GENE-492370
• Length: 1229
• Species: Xenopus tropicalis
• Alignment Length: 1128
• Identity: 305/1128 - (27%)
• Similarity: 471/1128 - (41%)
• Gaps: 334/1128 - (29%)

  Fly     1 MPESLIAGIPVHFPFEPYPVQRAYMEKVI-------HCLRDGTNGVLESPTGTGKTLSLLCSSLA 58
            :.|..|.|:.:.||...||.|.|.|..::       |||       ||||||:||:|:||||:||
 Frog     5 LSEYTIGGVKILFPCRAYPSQLAMMNSIMRGLNCKQHCL-------LESPTGSGKSLALLCSALA 62

  Fly    59 WIRT-------RQSEHQKQMVKMEK--------------------------------ADFSGLGG 84
            |.::       .:..::|:..|||:                                ::|.|...
 Frog    63 WQQSLYGKQAVDEKSNEKECTKMERVTPCCCSCHLRNSDELSFNSSNRQMNSTDSTPSNFQGASS 127

  Fly    85 GAP-------------------------------------------------------------- 87
            ...
 Frog   128 NKTTLAAKLCAKKQASFIADQDDDFQTDRKRIRQSHDEQQQAKKRRCYEKGVQFIDDDFNRNHTD 192

  Fly    88 ----------------------------------GGDLSELAKTM--GRANNW---GVPKVIYAS 113
                                              .|...|..|.:  |:..|.   .|||:.:.:
 Frog   193 LDSHNQKKASMDSCPEVIASSSNHSVGPCSLCLCDGQTKEEDKAIEKGKKENGEKPKVPKIFFGT 257

  Fly   114 RTHSQLTQAMRELKRTAYANMRSVVLGSRDQLCIHPEVMREQGNSNKTNMCKLRVHSK---TCSF 175
            |||.|:.|..|||:||||:::|..:|.||:..|:||::     :||:...||..:.:|   :|.|
 Frog   258 RTHKQIAQITRELRRTAYSSVRMTILSSREHTCVHPDI-----HSNRNEKCKELLEAKDGHSCRF 317

  Fly   176 QMRVESRKDHPDLR----GPTIMDIEDLVKVGQRLKICPYFASRELVPQADITFMPYNYLLDPKA 236
            ...|:...:...|:    .....|||:||.:|:||:.|||||:|||:.:|||.|.|||||||.:.
 Frog   318 YHGVQKMNEQNLLKYRHGVDKAWDIEELVGLGKRLRACPYFAARELMQEADIVFCPYNYLLDSQI 382

  Fly   237 RKANKIELGNTIVILDEAHNIEKICEESASVQIKSSDVAMAIED----VTHIMQVFASGESQDMA 297
            |::..|.|...:||||||||||....||||.......:..|.::    |.|.::|         :
 Frog   383 RESMDIFLEGQVVILDEAHNIEDCARESASFSCSDEQLMYARDEIDSMVNHGIRV---------S 438

  Fly   298 GDEPKDFTLDDLT----LLKEMLLELE----------KAIDAIVVDNAVDGTTFPASMMYELLGK 348
            ..||.......||    ...:.|:|.|          |.|.||..|..:...|||       |.|
 Frog   439 DHEPLRAVCYSLTNWIRECSDQLVEREYEASCKVWNGKEILAIFHDMGITNATFP-------LLK 496

  Fly   349 ANFTYGNVATIVSLLDKL---------VQYLLVASQQMSIRKGGTFTLLSDLL------------ 392
            |     |:|.:|...:|:         ::...::.|...:.| |.|.:|..|.
 Frog   497 A-----NLAAVVEKEEKITMLHGQENVIKIPTLSPQTQMVLK-GLFLVLDYLFRQNNRFAEDYRI 555

  Fly   393 ----TIVFANKEDVMSKVYASFKVHVLVEESKQGHGKQQGAKQQGGWLGKGTIAAATGLSKVAKI 453
                :..:||::|:                           ..:.|:..:.....|.....:...
 Frog   556 ALQQSYTWANRQDI---------------------------PDENGFFARPRNRRAVRQKIMVYT 593

  Fly   454 INFWCFNPGFGMEQLLNTQVRSVILTSGTLAPLKPLIAELAIPVAQHLENPHIVDQSQVYVKIIG 518
            :||||.||...... |::..|:::||||||:|:....:||.:..:..||..|::.:|||:|..:|
 Frog   594 LNFWCLNPAVAFSD-LSSNARTIVLTSGTLSPMGSFSSELGVKFSIQLEANHVIHKSQVWVGTVG 657

  Fly   519 TGPDRQQLISNYANRDNPKYISSLGQTILNVARIVPDGLLVFFPSYPMLNKCVDAWQASGLWADI 583
            .||..::|.:.:.:.:...:...:|..:|:|.:.|..|:|.|.|||.||.|..|.|..:|||.::
 Frog   658 AGPKGRKLCATFQHTETFDFQDEIGALLLSVCQTVSHGVLCFLPSYKMLEKLKDRWMHTGLWENL 722

  Fly   584 SCKKPIFLEPRSKDQ--FTSTMEEFYQAIR---DSKGAVFMAVCRGKVSEGLDFADRNGRAVIIT 643
            ...|.:..||:..|:  |...::.:|.|||   :..||:.:|||||||||||||:|.|.|||:..
 Frog   723 ERIKTVIKEPQGGDKTDFDKMLQMYYDAIRYKGEKDGALLIAVCRGKVSEGLDFSDNNARAVVTV 787

  Fly   644 GLPFPPLKDPKVILKRRYLEANRTRENQLLSGQEWYNLDATRAVNQAIGRVIRHRNDYGAILLCD 708
            |:|||.:||.:|.|||:|.: ...:...||.|.:||.:.|.||:|||:||.|||:||:||::|.|
 Frog   788 GIPFPNIKDLQVELKRKYND-QHAKSRGLLPGSQWYEIQAYRALNQALGRCIRHKNDWGALILVD 851

  Fly   709 SRFK-DASQVQQLSKWIRGHLGDRPQCSPFGPIVRELRQFFKNAEANMKL-------------PD 759
            .||: :...:..||||:|..:...   |.|...:..|.:|.||.:..|::             |.
 Frog   852 DRFRSNPKYITGLSKWVRQLVQHH---STFNGALESLNEFSKNQQQRMQISSTTCDEEPSLGAPS 913

  Fly   760 ERETDSPLETVCKTEDEPLAAIPKVKREPGSNATFKSANESAIKVEMANSIKTWTPADYASAAGH 824
            ..:..||..::.:....|..::.:.     :..|| |...|.:..|:|..:.. .||
 Frog   914 SSKNTSPTSSLLEFTVHPTQSVSEF-----TQPTF-STQSSTLPPEIAIPLSP-IPA-------- 963

  Fly   825 KLGGAAPNAMDFMSRLDSNVSSIDFNCCTDSKSGSSGLVKIHKRERSSPTAPESSSQVTKKRYKL 889
            .|.|.||       |.::.|.|                   |:.|..   ..|||:.|.....|.
 Frog   964 SLVGTAP-------RYNTEVIS-------------------HRNEEE---RRESSTSVKTNLMKT 999

  Fly   890 VENIKVEPSSSQAKEAPEERAAF 912
            .:|.|:..|        ::|.:|
 Frog  1000 FKNSKLNNS--------KQRTSF 1014

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rtel1	NP_572254.1	rad3	10..742	CDD:273169	266/934 (28%)
		HN_RTEL1	896..985	CDD:259826	3/17 (18%)
brip1	XP_002933884.1	DEAD-like_helicase_N	43..>68	CDD:475120	17/31 (55%)
		rad3	246..885	CDD:273169	229/697 (33%)