DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4078 and rtel1

DIOPT Version :9

Sequence 1:	NP_001259262.1	Gene:	CG4078 / 31497	FlyBaseID:	FBgn0029798	Length:	985	Species:	Drosophila melanogaster
Sequence 2:	XP_031750114.1	Gene:	rtel1 / 100487920	XenbaseID:	XB-GENE-6035930	Length:	1269	Species:	Xenopus tropicalis

Alignment Length:	1038	Identity:	394/1038 - (37%)
Similarity:	574/1038 - (55%)	Gaps:	127/1038 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPESLIAGIPVHFPFEPYPVQRAYMEKVIHCLRDGTNGVLESPTGTGKTLSLLCSSLAWIRTRQS 65
            ||:..:||:.|.|||:||..|..||.|||.||:.|.||||||||||||||.|||::|||     .
Frog     1 MPQVPVAGLTVDFPFQPYKCQEDYMGKVIQCLQQGVNGVLESPTGTGKTLCLLCATLAW-----R 60

  Fly    66 EHQKQMV-------KMEKAD-FSGLGGGAPGGDLSELAKTMGRANNW--GVPKVIYASRTHSQLT 120
            :|.|..:       :|..|: |......|.||     |...|:|:.:  .|||:|||||||||||
Frog    61 QHYKDGISARKIAERMNGAELFPERPAAAWGG-----ASAEGQASAYYSDVPKIIYASRTHSQLT 120

  Fly   121 QAMRELKRTAYANMRSVVLGSRDQLCIHPEVMREQGNSNKTNMCKLRVHSKTCSFQMRVESRKDH 185
            |.:.|||.|.| ..:..|||||:||||||||.:::.|..|.:||:.:|.::||.|...||.:...
Frog   121 QVISELKHTVY-RPKVCVLGSREQLCIHPEVKKQESNHAKVHMCRSKVSTRTCHFYNNVEEKSTE 184

  Fly   186 PDLRGPTIMDIEDLVKVGQRLKICPYFASRELVPQADITFMPYNYLLDPKARKANKIELGNTIVI 250
            .||.. .|:|||||||.|.:.:.|||:.||.|..||||.|||||||||||:|:|:.|:|..|:||
Frog   185 KDLTN-HILDIEDLVKSGTKHRACPYYLSRNLKQQADIIFMPYNYLLDPKSRRAHNIDLKGTVVI 248

  Fly   251 LDEAHNIEKICEESASVQIKSSDVAMAIEDVTHIMQVFASGESQDMAGDEPK----DFTLD---- 307
            .|||||:|::||:|:|..:...|:|..|:.:..:::       :.|...|.|    :|.:|
Frog   249 FDEAHNVERMCEDSSSFDLTPYDLASGIDAMDLVLK-------EQMENVEQKRYQAEFNMDSQSS 306

  Fly   308 -------DLTLLKEMLLELEKAIDAIVVDNAVDGTTFPASMMYELLGKANFTYGNVATIVSLLDK 365
                   ||..:|..|::||.:|::..:.....|.|...|.:::|...:..|:...|.::..|::
Frog   307 GLTLELEDLAKVKAALMQLENSIESTQLPPGGGGVTKVGSYIFQLFAASGITFDTKAKLLESLEQ 371

  Fly   366 LVQYLLVASQQMSIRKGGTFT------LLSDLLTIVF-------ANKEDVMSKVYASFKVHVLVE 417
            ::|::..:|        |.||      .|:|::.|||       ||.......:...:|||:..:
Frog   372 IIQHVGGSS--------GIFTNTMGLQKLADIIQIVFSMEPPEGANVSSFNQNISKYYKVHIHPD 428

  Fly   418 ESKQGHGKQQG-----AKQQGGWLGKGTIAAATGLSKVAKIINFWCFNPGFGMEQLLNTQVRSVI 477
            .:::  .|.:|     :|:|||                 |::::|||:||:.|..|:...||.||
Frog   429 TNQR--KKPRGDVWSNSKKQGG-----------------KVLSYWCFSPGYTMHDLVRQGVRCVI 474

  Fly   478 LTSGTLAPLKPLIAELAIPVAQHLENPHIVDQSQVYVKIIGTGPDRQQLISNYANRDNPKYISSL 542
            ||||||.||.....|:.||....|||||::|:.|::|.|:..|||..||.|:|..|.:.:|:|||
Frog   475 LTSGTLCPLSSFTMEMQIPFPVSLENPHVIDKHQIWVGIVPRGPDGSQLSSSYDRRFSEEYLSSL 539

  Fly   543 GQTILNVARIVPDGLLVFFPSYPMLNKCVDAWQASGLWADISCKKPIFLEPRSKDQFTSTMEEFY 607
            |:||.|:||:||.||||||||||:|:|.::.|:..||.|.|...||:|:|||.|..||..::.:|
Frog   540 GKTIGNIARVVPHGLLVFFPSYPVLDKSIEFWKERGLSAKIDDVKPMFVEPRGKGSFTEVIDAYY 604

  Fly   608 QAIR--DSKGAVFMAVCRGKVSEGLDFADRNGRAVIITGLPFPPLKDPKVILKRRYLEANRTREN 670
            :.||  :..||.|:||||||.||||||||.|||.||||||||||..||:|:||.::|:..|..:.
Frog   605 EKIRSANGSGASFLAVCRGKASEGLDFADNNGRGVIITGLPFPPRMDPRVVLKMQFLDEMRRSQG 669

  Fly   671 Q---LLSGQEWYNLDATRAVNQAIGRVIRHRNDYGAILLCDSRFKDASQVQQLSKWIRGHLGDRP 732
            .   .|||||||...|:||||||||||||||||||||.|||.||..:....||..|:|.::....
Frog   670 SAGLYLSGQEWYRQQASRAVNQAIGRVIRHRNDYGAIFLCDHRFNQSDARAQLPSWVRPYVRTYD 734

  Fly   733 QCSPFGPIVRELRQFFKNAEANMKLP----DERETDSPLETVCKTEDEPLAAIPKVKREPGSNAT 793
            .   ||.|:|::.|||:.|...|..|    |::|...||.........|:|  |...||....|.
Frog   735 N---FGHIIRDVSQFFRVALKIMPTPTLHSDQKEGPVPLIGCSSQSPRPVA--PSSSREAPKKAK 794

  Fly   794 FKSANESAIKVEMANSIKTWTPADYASAAGHKLGGAAPNAMDFMSRLDSNVSSIDFNCCTDSKSG 858
            ...::..::|.:.........|.........::..::......:..|:.:...:.     :.|:|
Frog   795 TLDSHVPSLKRKRDECSSEVVPGSVCEGYEQEVPMSSQRPAGLLDALEHSEKRVQ-----EEKAG 854

  Fly   859 SSGLVKIHKRERSSPTAPESSSQVT------KKRYKLVENIKVEPSSSQAKEAPEERAAFLRELR 917
                   .|..|.|..:.:...::.      |::.|:|:|...|.:|.|...:   .:.||..::
Frog   855 -------EKVSRLSTLSLQYDKRLADEQRGGKRKIKIVQNRAPEDTSDQKMTS---ASLFLVSVK 909

  Fly   918 SLVTQDQFRRFGKALLEYKNGTYESFQALMAILLDVLSAPKVRY-MLVGMRKYLKNEHKDEFD 979
            ..::|:.:..|..|:.|||..  ...|.|::.|..:......:| :|.|..::::.:||.|||
Frog   910 QSLSQENYGTFMAAMTEYKKN--NDLQQLISHLRTLFCQDPAKYNLLRGFYQFIRPQHKLEFD 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4078	NP_001259262.1	rad3	10..742	CDD:273169	339/779 (44%)
		DEAD_2	111..274	CDD:284209	88/162 (54%)
		Helicase_C_2	546..725	CDD:290046	108/183 (59%)
		HN_RTEL1	896..985	CDD:259826	22/85 (26%)
rtel1	XP_031750114.1	rad3	8..741	CDD:273169	340/781 (44%)
		HN_RTEL1	881..981	CDD:259826	25/95 (26%)
		HN_RTEL1	1028..1128	CDD:259826
		RING_Ubox	1208..1247	CDD:418438
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2542
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	636	1.000	Inparanoid score	I821
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141017at33208
OrthoFinder	1	1.000	-	-		FOG0006111
OrthoInspector	1	1.000	-	-		oto103039
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4406
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060