DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS6 and Ints6l

DIOPT Version :9

Sequence 1:	NP_001259259.1	Gene:	IntS6 / 31496	FlyBaseID:	FBgn0261383	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_038956476.1	Gene:	Ints6l / 681665	RGDID:	1592872	Length:	907	Species:	Rattus norvegicus

Alignment Length:	940	Identity:	322/940 - (34%)
Similarity:	461/940 - (49%)	Gaps:	197/940 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 AKGAVE--------TFLK-YRQRTQDCLGDRYMLLTFEEPPANVKAGWKENHATFMNELKNLQSH 86
            |:|.||        ::|| :|..|.  :||         ....|:|||||||||||:||||||:.
  Rat    39 AEGLVEVVFSLISASYLKVFRPGTG--IGD---------VEGQVQAGWKENHATFMSELKNLQAS 92

  Fly    87 GLTSMGESLRNAFDLLNLNRMQSGIDTYGQGRCPFYLEPSVIIVITDGGRYSYRNGVHQEIILPL 151
            |||::|::||::||||||||:.||||.|||||.||:||||::|.||||.:.:....|.:|:.|||
  Rat    93 GLTTLGQALRSSFDLLNLNRLISGIDNYGQGRNPFFLEPSILITITDGNKLTSTASVQEELHLPL 157

  Fly   152 SNQIPGTKFTKEPFRWDQRLFSLVLRMPGNKIDERVD-GKVPHDDSPIERMCEVTGGRSYRVRSH 215
            ::.:||::.||||||||||||:||||:||....|... |.||.|:|.|.:||||||||||.||:.
  Rat   158 NSPLPGSELTKEPFRWDQRLFALVLRLPGVASPEPEQLGSVPSDESAITQMCEVTGGRSYCVRTQ 222

  Fly   216 YVLNQCIESLVQKVQPGVVLQFEPMLPKEATSATAGEAAGASTISGMGISSTSGAGPAPDIVFQP 280
            .:||||:||||||||.|||:.||...|...       ..|..|:       .....|......||
  Rat   223 RMLNQCLESLVQKVQSGVVINFEKTGPDPL-------PVGEDTL-------MDSCRPNNFFAAQP 273

  Fly   281 ---VKKMIYVQKHITQKT-FPIGYWPLPEPYWPDSKAITLPPRDAHPKLKVLTPAVD-EPQLVRS 340
               ..|:|||:.:  .|| .|:|:||:||.:||:....:||||.:||.::.  ..|| ||.::..
  Rat   274 WHSCHKLIYVRPN--SKTGVPVGHWPIPESFWPEQNLPSLPPRTSHPVVRF--SCVDCEPMVIDK 334

  Fly   341 FPVDKYEIEGCPLTLQILNKREMNKCWQVIVTNGMHGFEL--PFGYLKAAPNFSQVHLYVLAYNY 403
            .|.||||:|..|||..||.::..:.||||.||:.....||  |||||||:...:.|:|:|:.|||
  Rat   335 LPFDKYELEPSPLTQYILERKSPHTCWQVFVTSSSKYNELGYPFGYLKASTTLTCVNLFVMPYNY 399

  Fly   404 PALLPILHDLIHKYNMSPPSDLMYKFNAYVRSIPPYYCPFLRKALVNINVPYQLLQFLLPENVDN 468
            |.|||:|.||...:.:.|.......|::|::::||||...|:|||..:..|.     |:.:|:|.
  Rat   400 PVLLPLLDDLFKVHKLKPNLKWRQAFDSYLKTLPPYYLIPLKKALRMMGAPN-----LISDNLDC 459

  Fly   469 YLSPTIANQLKHIKNTAKQDQENLCMKVYKQLKQPKPPYR-----QVETGKLFTGAPLRRDLVRH 528
            .||.::.:.||.:....|.:.|.:...|.|     |||..     :..:|   :|.||..:....
  Rat   460 GLSYSVISYLKKLSQQTKLESERVLASVGK-----KPPQEIGIKVKNHSG---SGLPLAHNKSFR 516

  Fly   529 PLLRDIFSKLH---GEIDPVENYTIVVPQPTHQSSAKSHRNPFDIPRRDLVEEIAKMRETLLRPV 590
            .||::|..:..   .|::..|.....|.........:::||.:|||||.|::::.:||..||:..
  Rat   517 KLLKEIIGESAPRLTELNTKEFAGFQVGLLNKDLKPQTYRNAYDIPRRGLLDQLTRMRSNLLQTR 581

  Fly   591 SLVA---KDSGHCLPIAEMGNYQEYLKNKDNPLREIEPTN-VRQHMFGNPYKKDKHMVMVDEADL 651
            ..:.   :||.|.:|:|:|||||||||...:|||||:|.. .|.|.||||:|:||..:|:||||.
  Rat   582 KFIVGQDEDSLHSVPVAQMGNYQEYLKMLASPLREIDPDQPKRLHTFGNPFKQDKKGMMIDEADE 646

  Fly   652 SDVAPMKSPNGNGPGGAPPGSPSGSG-----SPTGPGPSSPGSSPG--GGSGP----GMPGMPGM 705
            ..|.|.......|    .|.||..|.     ||....|..|.::..  ||.||    ..|..|.:
  Rat   647 FVVGPQNKVKRPG----EPNSPMSSKRRRSMSPLLKKPQIPPTATNHVGGKGPLSTSWFPSCPNL 707

  Fly   706 GGGMSGLMLGAGGSGGSSKKLDGTSRGRKRKAGPLPRSFEFRRSSTDSRSSSSGSESSTTGSAPG 770
                                              :..:|....::.   ...:..|....|.:|
  Rat   708 ----------------------------------IKHTFVHPDTAV---IHDTHEEKMENGQSP- 734

  Fly   771 SPIPGATSSISGCDSAMGADGGPSSSCFDEDSNSNSSFVSSTSEA---SASDSGMSNSHLDPLRI 832
                              |||                |:..::.|   :.|..|:..:.||.|..
  Rat   735 ------------------ADG----------------FLLKSAPAEFMNVSGEGLIPNQLDSLSD 765

  Fly   833 SFVFIEEETSDQDTPLNGYVHNFINGISDDAETGETEAVPGGASLPGASSAN---EPSSIGASPA 894
            .|..:.::         |::|...|.|                .|.||.:.|   :...|..:.|
  Rat   766 DFTGLRKD---------GFIHKPGNNI----------------LLGGAKTCNLSVDDQKITMASA 805

  Fly   895 VSATPATSVIPASNGSEVCSAVAAGSSSSI 924
            :...|        |..::..|:|.|.::.|
  Rat   806 LETVP--------NSMQITPAMAQGINADI 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS6	NP_001259259.1	vWFA	4..>147	CDD:238119	63/124 (51%)
IntS6	NP_001259259.1	INT_SG_DDX_CT_C	1196..1257	CDD:291946
Ints6l	XP_038956476.1	INT_SG_DDX_CT_C	823..884	CDD:405888	1/5 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	341	1.000	Domainoid score	I1047
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H52110
Inparanoid	1	1.050	572	1.000	Inparanoid score	I1018
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D551849at2759
OrthoFinder	1	1.000	-	-		FOG0003020
OrthoInspector	1	1.000	-	-		otm46443
orthoMCL	1	0.900	-	-		OOG6_103620
Panther	1	1.100	-	-	O	PTHR12957
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2010
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.970