DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS6 and ints6l

DIOPT Version :9

Sequence 1:	NP_001259259.1	Gene:	IntS6 / 31496	FlyBaseID:	FBgn0261383	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_956728.1	Gene:	ints6l / 393406	ZFINID:	ZDB-GENE-040426-1150	Length:	892	Species:	Danio rerio

Alignment Length:	894	Identity:	354/894 - (39%)
Similarity:	479/894 - (53%)	Gaps:	134/894 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTIILFLVDTSSSMCQKAYVNGVQKTYLDIAKGAVETFLKYRQRTQDCLGDRYMLLTFEEPPANV 65
            |.|:|||:|||:||.|:.|:.   .|||||||||||.|:|.|.|.....||||||:||::||..|
Zfish     1 MPILLFLIDTSASMNQRTYLG---TTYLDIAKGAVEIFMKLRARDPASRGDRYMLVTFDDPPYGV 62

  Fly    66 KAGWKENHATFMNELKNLQSHGLTSMGESLRNAFDLLNLNRMQSGIDTYGQGRCPFYLEPSVIIV 130
            ||||||||||||:||||||:.|||::|.:||.|||||||||:.||||.|||||.||:|||||||.
Zfish    63 KAGWKENHATFMSELKNLQASGLTTLGHALRAAFDLLNLNRLVSGIDNYGQGRNPFFLEPSVIIT 127

  Fly   131 ITDGGRYSYRNGVHQEIILPLSNQIPGTKFTKEPFRWDQRLFSLVLRMPGNKI-DERVDGKVPHD 194
            ||||.:.::.:||.:|:.|||::.:||::.||||||||||||:||||:||..: |....|.||.|
Zfish   128 ITDGNKLTHSSGVAEELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGVAVPDSEQLGSVPTD 192

  Fly   195 DSPIERMCEVTGGRSYRVRSHYVLNQCIESLVQKVQPGVVLQFEPMLPKEATSATAGEAAGASTI 259
            :|.|.:||||||||||.||:..:||||:|||||||..|||:.||...|........|....|..:
Zfish   193 ESAITQMCEVTGGRSYCVRTQRMLNQCLESLVQKVLSGVVIHFEKTGPDPPVIGEDGLVDPARPL 257

  Fly   260 SGMGISSTSGAGPAPDIVFQPVKKMIYVQKHITQKT-FPIGYWPLPEPYWPDSKAITLPPRDAHP 323
            :..        .|.|   :....|:|||:.:  .|| .|:|:||:.|.:|||..:.|||||.|||
Zfish   258 TSF--------SPQP---WHSCHKLIYVRPN--PKTGVPVGHWPISESFWPDQNSPTLPPRSAHP 309

  Fly   324 KLKVLTPAVD-EPQLVRSFPVDKYEIEGCPLTLQILNKREMNKCWQVIVT-NGMHG-FELPFGYL 385
            .::.  ..|| ||.::...|.||||:|..|||..||.::..:.||||.|. :|.|. ...|||||
Zfish   310 VVRF--SCVDCEPMVIDKLPFDKYELEPSPLTQYILERKSPHMCWQVFVNCSGKHSDVAHPFGYL 372

  Fly   386 KAAPNFSQVHLYVLAYNYPALLPILHDLIHKYNMSPPSDLMYKFNAYVRSIPPYYCPFLRKALVN 450
            ||:...:.|:|:|:.||||.|||:|.||...:.:.|.......|..|::|:||||...|:|||..
Zfish   373 KASTTLTCVNLFVMPYNYPVLLPLLDDLFKVHKLKPNLKWRQSFEMYLKSMPPYYLLPLKKALRM 437

  Fly   451 INVPYQLLQFLLPENVDNYLSPTIANQLKHIKNTAKQDQENLCMKVYKQLKQPKPPYRQVETG-- 513
            :..|.     |:.:|:|..||.::.:.||.:...||.:.:.|.:.|.|     |||   .|||
Zfish   438 MGAPN-----LISDNMDCGLSYSVISYLKKLSQQAKIESDRLIVSVGK-----KPP---PETGIK 489

  Fly   514 -KLFTGA---PLRRDLVRHPLLRDIFSKLHGEIDPVE----------NYTIVV------PQPTHQ 558
             |..:.|   ..|||      .:.:...:.||: |:.          .:.|.:      ||
Zfish   490 VKNHSNALSLAHRRD------FKQLLQGITGEV-PLRLIDMNFKEFAGFQIALLNKDLKPQ---- 543

  Fly   559 SSAKSHRNPFDIPRRDLVEEIAKMRETLLRPVSLVAK----DSGHCLPIAEMGNYQEYLKNKDNP 619
                ::||.:|||||:|::::.:||..|||....:.:    ||.|.:|:.:|||||||||...:|
Zfish   544 ----AYRNAYDIPRRNLLDQVTRMRSNLLRTTQKLIRGQDDDSLHSIPVGQMGNYQEYLKMMPSP 604

  Fly   620 LREIEPTN-VRQHMFGNPYKKDKHMVMVDEADLSDVAPMKSPNGNGPGGAPPGSP---SGSGSPT 680
            ||||:|.. .|.|.||||:|:||..:|:||||.....|.....|| .|....|:.   ..|.||.
Zfish   605 LREIDPDQPKRLHTFGNPFKQDKKGMMIDEADEFVTGPQNKKRGN-TGDLNSGTALKRRRSMSPL 668

  Fly   681 GPGPSSPGSSPGGGSGPGMPGMPGMGGGMSGLMLGAGGSGGSSKKLDGTSRGRKRKAGPLPRSFE 745
            ...|.:|........|.|..|..|..|.:..:.|..|..|.:   :.||....:|.||
Zfish   669 LRRPQTPPIITNHVLGKGPTGTQGQQGIIKPIPLHKGAEGNN---VGGTESNGERVAG------- 723

  Fly   746 FRRSSTDSRSSSSGSESSTTGSAPGSPIPGATSSISGCDSAMGADGGPS----SSCFDE---DSN 803
                 ||:.....|.....:    |.|.|     :...:.|...||...    .:|.|:   |..
Zfish   724 -----TDAGDCWPGEVDGES----GEPAP-----VEDREDAAAPDGEEEILALENCLDDRSPDHT 774

  Fly   804 SNSSFVSSTSEASASDSGMSNSHLDPLRISFVFIEEETSDQDTPLNGYV 852
            .|...:|...:..                     |.|.::.|||..|.:
Zfish   775 QNCEELSPPGQEG---------------------EMEVNEGDTPAQGTI 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS6	NP_001259259.1	vWFA	4..>147	CDD:238119	93/142 (65%)
IntS6	NP_001259259.1	INT_SG_DDX_CT_C	1196..1257	CDD:291946
ints6l	NP_956728.1	vWFA	4..>131	CDD:238119	89/129 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	665..692		7/26 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	711..754		12/63 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	771..793		5/42 (12%)
		INT_SG_DDX_CT_C	810..870	CDD:291946
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596803
Domainoid	1	1.000	360	1.000	Domainoid score	I913
eggNOG	1	0.900	-	-		E1_KOG3768
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H52110
Inparanoid	1	1.050	589	1.000	Inparanoid score	I949
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D551849at2759
OrthoFinder	1	1.000	-	-		FOG0003020
OrthoInspector	1	1.000	-	-		otm24648
orthoMCL	1	0.900	-	-		OOG6_103620
Panther	1	1.100	-	-	O	PTHR12957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3035
SonicParanoid	1	1.000	-	-		X2010
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.790