DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS6 and INTS6

DIOPT Version :9

Sequence 1:	NP_001259259.1	Gene:	IntS6 / 31496	FlyBaseID:	FBgn0261383	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_036273.1	Gene:	INTS6 / 26512	HGNCID:	14879	Length:	887	Species:	Homo sapiens

Alignment Length:	918	Identity:	354/918 - (38%)
Similarity:	489/918 - (53%)	Gaps:	156/918 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTIILFLVDTSSSMCQKAYVNGVQKTYLDIAKGAVETFLKYRQRTQDCLGDRYMLLTFEEPPANV 65
            |.|:|||:|||:||.|::::.   .||||.||||||||:|.|.|.....||||||:||||||..:
Human     1 MPILLFLIDTSASMNQRSHLG---TTYLDTAKGAVETFMKLRARDPASRGDRYMLVTFEEPPYAI 62

  Fly    66 KAGWKENHATFMNELKNLQSHGLTSMGESLRNAFDLLNLNRMQSGIDTYGQGRCPFYLEPSVIIV 130
            |||||||||||||||||||:.|||::|:|||.|||||||||:.:|||.|||||.||:|||::||.
Human    63 KAGWKENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQGRNPFFLEPAIIIT 127

  Fly   131 ITDGGRYSYRNGVHQEIILPLSNQIPGTKFTKEPFRWDQRLFSLVLRMPGNKI--DERVDGKVPH 193
            ||||.:.:..:||..|:.|||::.:||::.||||||||||||:||||:||...  .|::.| ||.
Human   128 ITDGSKLTTTSGVQDELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGTMSVESEQLTG-VPL 191

  Fly   194 DDSPIERMCEVTGGRSYRVRSHYVLNQCIESLVQKVQPGVVLQFEPMLPKEATSATAGEAAGAST 258
            |||.|..||||||||||.|.|..:||||:||||||||.|||:.||...| :.:....|:.
Human   192 DDSAITPMCEVTGGRSYSVCSPRMLNQCLESLVQKVQSGVVINFEKAGP-DPSPVEDGQP----- 250

  Fly   259 ISGMGISSTSGAGPAPDIVFQPVKKMIYVQKHITQKT-FPIGYWPLPEPYWPDSKAITLPPRDAH 322
                .||...|:.|     :....|:|||:.:  .|| .|||:||:||.:|||..:.|||||.:|
Human   251 ----DISRPFGSQP-----WHSCHKLIYVRPN--PKTGVPIGHWPVPESFWPDQNSPTLPPRTSH 304

  Fly   323 PKLKVLTPAVD-EPQLVRSFPVDKYEIEGCPLTLQILNKREMNKCWQVIVTNGMHGFEL--PFGY 384
            |.:|.  ...| ||.::...|.||||:|..|||..||.::....||||.|:|.....||  ||||
Human   305 PVVKF--SCTDCEPMVIDKLPFDKYELEPSPLTQFILERKSPQTCWQVYVSNSAKYSELGHPFGY 367

  Fly   385 LKAAPNFSQVHLYVLAYNYPALLPILHDLIHKYNMSPPSDLMYKFNAYVRSIPPYYCPFLRKALV 449
            |||:...:.|:|:|:.||||.|||:|.||...:...|.......|.:|::::||||...|:||:.
Human   368 LKASTALNCVNLFVMPYNYPVLLPLLDDLFKVHKAKPTLKWRQSFESYLKTMPPYYLGPLKKAVR 432

  Fly   450 NINVPYQLLQFLLPENVDNYLSPTIANQLKHIKNTAKQDQENLCMKVYKQLKQPKPPYRQVETG- 513
            .:..|.     |:.::::..||.::.:.||.:...||.:.:.:...|.|::.|        |||
Human   433 MMGAPN-----LIADSMEYGLSYSVISYLKKLSQQAKIESDRVIGSVGKKVVQ--------ETGI 484

  Fly   514 KLFT-----GAPLRRDLVRHPLLRDIFSKL-HGEID-PVENYT-IVVPQPTHQSSAKSHRNPFDI 570
            |:.:     ....|:|.  ..||:.|...: |..:| .::.|| ..|.........::.||.:||
Human   485 KVRSRSHGLSMAYRKDF--QQLLQGISEDVPHRLLDLNMKEYTGFQVALLNKDLKPQTFRNAYDI 547

  Fly   571 PRRDLVEEIAKMRETLLRPVSLVAK----DSGHCLPIAEMGNYQEYLKNKDNPLREIEPTNVRQ- 630
            |||:|::.:.:||..||:......|    |..|.:|||:|||||||||...:||||::|...|:
Human   548 PRRNLLDHLTRMRSNLLKSTRRFLKGQDEDQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRL 612

  Fly   631 HMFGNPYKKDKHMVMVDEADLSDVAPMKSPNGNGPGGAPPGSPSGSGSPTGPGPSSPGSSPGGGS 695
            |.||||:|.||..:|:|||| ..||                           ||.:....||
Human   613 HTFGNPFKLDKKGMMIDEAD-EFVA---------------------------GPQNKHKRPG--- 646

  Fly   696 GPGMPGMPGMGGGMSGLMLGAGGSGGSSKKLDGTSRGRKRKAGPLPRSFEFRRSSTDSRSSSSGS 760
            .|.|.|:|.....||.|:.|                   |:..|:          .::.....|.
Human   647 EPNMQGIPKRRRCMSPLLRG-------------------RQQNPV----------VNNHIGGKGP 682

  Fly   761 ESSTTGSAPG--SPIPGATSSISGCDSAMGADGGPSSSCFDEDSNSNSSFVSSTSEASASDSGMS 823
            .:.||.:.|.  .|:|....|.:..||.:          .|...|..:..:||....:|.|:..|
Human   683 PAPTTQAQPDLIKPLPLHKISETTNDSII----------HDVVENHVADQLSSDITPNAMDTEFS 737

  Fly   824 NS-----------HLDPLRISFVFIEEETSDQDTPLNGYVHNFINGISDDAETGETEAVPGGASL 877
            .|           |::.|.      .:.....|..:.|::.|  :....|.|....|.:|
Human   738 ASSPASLLERPTNHMEALG------HDHLGTNDLTVGGFLEN--HEEPRDKEQCAEENIP----- 789

  Fly   878 PGASSANE 885
              |||.|:
Human   790 --ASSLNK 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS6	NP_001259259.1	vWFA	4..>147	CDD:238119	92/142 (65%)
IntS6	NP_001259259.1	INT_SG_DDX_CT_C	1196..1257	CDD:291946
INTS6	NP_036273.1	VWA_2	4..103	CDD:404413	69/101 (68%)
INTS6	NP_036273.1	INT_SG_DDX_CT_C	809..868	CDD:405888
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160426
Domainoid	1	1.000	338	1.000	Domainoid score	I1109
eggNOG	1	0.900	-	-		E1_KOG3768
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	568	1.000	Inparanoid score	I1074
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D551849at2759
OrthoFinder	1	1.000	-	-		FOG0003020
OrthoInspector	1	1.000	-	-		otm42293
orthoMCL	1	0.900	-	-		OOG6_103620
Panther	1	1.100	-	-	LDO	PTHR12957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3035
SonicParanoid	1	1.000	-	-		X2010
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790