DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS6 and ints-6

DIOPT Version :9

Sequence 1:	NP_001259259.1	Gene:	IntS6 / 31496	FlyBaseID:	FBgn0261383	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_001294213.1	Gene:	ints-6 / 24104403	WormBaseID:	WBGene00000994	Length:	872	Species:	Caenorhabditis elegans

Alignment Length:	914	Identity:	218/914 - (23%)
Similarity:	366/914 - (40%)	Gaps:	217/914 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTIILFLVDTSSSMCQKAYVNGVQKTYLDIAKGAVETFLKYRQRTQDCL-----GDRYMLLTFE- 59
            |....|::|||.||..:|:   .|.::.|:||..:|.|:|.|.:..:.:     .|:|.|:|.:
Worm     1 MPCFFFILDTSGSMSTRAH---PQFSFFDLAKNFIENFIKQRTKGDNRMMVGRETDKYFLMTTQA 62

  Fly    60 EPPANVKAGWKENHATFMNELKNLQ-SHGLTSMGESLRNAFDLLNLNRMQSGIDTYGQGRCPFYL 123
            ..|.|||...::..|..:.|:|.|. .:|...:..::..||.:|:::|:|:|||..|.||.....
Worm    63 RYPKNVKVACEKLGAVVIEEIKKLHLPYGSCQLHHAILEAFKVLHVSRVQTGIDGVGIGRLISNT 127

  Fly   124 EPSVIIVITDGGRYSYRNGVHQEIILPLSNQIPGTKFTKEPFRWDQRLFSLVLRMPGNKIDERVD 188
            ||..:|::|||...:   |:..:..|.......|::.|::.|||||:.:::|.|:|.......:.
Worm   128 EPVTMILLTDGSGVA---GIPIDFRLFFDPPFLGSEMTRDAFRWDQKFYTVVFRIPSTPYRPTIS 189

  Fly   189 GKVPHD-DSP-IERMCEVTGGRSYRVRSHYVLNQCIESLV---QKVQPGVVLQFEPMLPKEATSA 248
            .....| |.| |||:|..|||||:.:.|...:...|:.|:   .:.:.||..:..|.:...|...
Worm   190 QLTAIDIDMPVIERLCARTGGRSFSIVSPRQIQTTIDYLLAMGNQYKIGVRFECLPAIHFTAAPI 254

  Fly   249 TAGEAAGASTISGMGISSTSGAGPAPDIVFQPVKKMI------YVQKHITQKTFPIG-YWPLPEP 306
            |:.|.                     ::|....||:|      .:...:..:..|:. :||:||.
Worm   255 TSDEV---------------------NLVKMKFKKVIDKRPVTNIISRLNPQARPVTCHWPIPES 298

  Fly   307 YWPDSKAITLPPRDAHPKL---KVLTPAVDEPQLVRSFPVDKYEIEG---CPLTLQILNKREMNK 365
            ::|......||.|.:||.:   .:..|....|:|    ||||.|:|.   ..:.::||..|:...
Worm   299 FFPMRTMDQLPQRTSHPVILCAPIALPLHIRPEL----PVDKLELEPGGISDIIMEILQGRKDMT 359

  Fly   366 CWQVIVTNGMHGFELPFGYLKAAPNFSQVHLYVLAYNYPALLPILHDLIHKYNMSPPSDLMYKFN 430
            .| ..:....:|...|||.|:.....:.:.|.::.:|:|.|..::.:::.:..::.......|..
Worm   360 VW-TYMEGSSNGPTAPFGCLRMNTLGTGITLILMPFNFPMLYSLVEEIVKEPFLNKSQVWRSKLE 423

  Fly   431 AYVRSIPPYYCPFLRKAL--VNINVPYQLLQFLLPENVDNYLSPTIANQLKHIKNTAKQ--DQEN 491
            :|..::|.||...:|..|  .::.|.|.       .::..:....:.:.|...|..|::  ||..
Worm   424 SYFHTVPFYYNTQIRVCLDKFDVKVDYS-------SSMSMFYPGQLLSNLNRFKAKAREELDQMA 481

  Fly   492 LCMKV--YKQLKQPKPPYRQVETGKLFTGAPLRRDLVRHPLLRDIFSKLHGEIDPVENY------ 548
            :..|:  .|.||...|..|            :.|...|..::....|::..|.|.:|.|
Worm   482 IASKLNDSKTLKIVNPSIR------------IERITSRSTIIGLGNSEVDIEDDSLEGYESTPIY 534

  Fly   549 ------TIVVPQPTHQSSAKSHRNPFDIPRRDLVEEIAKMRE-----------TLLRPVSLVAK- 595
                  .:..|..|......::|.|:..|..||..::.:::.           |||....|..|
Worm   535 AGDFKIPLYPPSITDAQLDSAYRTPYSSPIEDLTSKLNRIQANIELMFDPNKITLLDMAKLGTKA 599

  Fly   596 -----DSGHCLPIAEMGNYQEY----LKNKDNPLREIEPTNVRQHMFGNPYKKDKHMVMVDEADL 651
                 :..|.:|...||.|:.|    :|....|:|:|:....|.|.||||||.......:||  :
Worm   600 RFNTLEELHNMPQKLMGEYEPYQAARVKYYGQPMRKIDEEKDRTHAFGNPYKLKGLGAGIDE--V 662

  Fly   652 SDVAPMKSPNGNGPGGAPPGSPSGSGSPTGPGPSSPGSSPGGGSGPGMPGMPGMGGGMSGLMLGA 716
            .|.|.:.:           .|||.||.|...|                               |.
Worm   663 MDSAVVDN-----------NSPSTSGQPKRFG-------------------------------GE 685

  Fly   717 GGSGGSSKKLDGTSRGRKRKAGPLP----RSFEFRRSSTDSRSSSSGSESSTTGSAPGSPIPGAT 777
            |..||...         ||:.|||.    ..:..|||   .|.||:||:
Worm   686 GRQGGGPP---------KRRRGPLGIDAYDQYRIRRS---MRGSSAGSD---------------- 722

  Fly   778 SSISGCDSAMGADGGPSSSCFDEDSNSNSSFVSSTSEASASDSGMSN--SHLDPLRISFVFIEEE 840
              ||...|::|.        ||:||:.          .:...|||:.  |..|.|::.    |.:
Worm   723 --ISDISSSLGT--------FDQDSDM----------TTPGTSGMNTPISEFDDLQLQ----EMD 763

  Fly   841 TSDQ 844
            :.||
Worm   764 SDDQ 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS6	NP_001259259.1	vWFA	4..>147	CDD:238119	46/149 (31%)
IntS6	NP_001259259.1	INT_SG_DDX_CT_C	1196..1257	CDD:291946
ints-6	NP_001294213.1	VWA	4..157	CDD:214621	47/158 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167873
Domainoid	1	1.000	71	1.000	Domainoid score	I6220
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	181	1.000	Inparanoid score	I2664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D551849at2759
OrthoFinder	1	1.000	-	-		FOG0003020
OrthoInspector	1	1.000	-	-		oto20282
orthoMCL	1	0.900	-	-		OOG6_103620
Panther	1	1.100	-	-	LDO	PTHR12957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3035
SonicParanoid	1	1.000	-	-		X2010
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.930