DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS6 and Ints6l

DIOPT Version :9

Sequence 1:	NP_001259259.1	Gene:	IntS6 / 31496	FlyBaseID:	FBgn0261383	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_006528039.1	Gene:	Ints6l / 236790	MGIID:	2442593	Length:	898	Species:	Mus musculus

Alignment Length:	956	Identity:	347/956 - (36%)
Similarity:	495/956 - (51%)	Gaps:	170/956 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTIILFLVDTSSSMCQKAYVNGVQKTYLDIAKGAVETFLKYRQRTQDCLGDRYMLLTFEEPPANV 65
            |.|:|||:|||:||.|:   ..:..:||||||||||.|||.|.|.....||||||:|::|||..:
Mouse     1 MPILLFLIDTSASMNQR---TDLGTSYLDIAKGAVELFLKLRARDPASRGDRYMLVTYDEPPYCI 62

  Fly    66 KAGWKENHATFMNELKNLQSHGLTSMGESLRNAFDLLNLNRMQSGIDTYGQGRCPFYLEPSVIIV 130
            |||||||||||||||||||:.|||::|::||::||||||||:.||||.|||||.||:||||::|.
Mouse    63 KAGWKENHATFMNELKNLQASGLTTLGQALRSSFDLLNLNRLISGIDNYGQGRNPFFLEPSILIT 127

  Fly   131 ITDGGRYSYRNGVHQEIILPLSNQIPGTKFTKEPFRWDQRLFSLVLRMPGNKIDERVD-GKVPHD 194
            ||||.:.:....|.:|:.|||::.:||::.||||||||||||:||||:||....|... |.||.|
Mouse   128 ITDGNKLTSTASVQEELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGVASTEPEQLGSVPSD 192

  Fly   195 DSPIERMCEVTGGRSYRVRSHYVLNQCIESLVQKVQPGVVLQFEPMLPKEATSATAGEAAGASTI 259
            :|.|.:||||||||||.||:..:||||:||||||||.|||:.||...|...       ..|..|:
Mouse   193 ESAITQMCEVTGGRSYCVRTQRMLNQCLESLVQKVQSGVVINFEKTGPDPL-------PVGEDTL 250

  Fly   260 SGMGISSTSGAGPAPDIVFQP---VKKMIYVQKHITQKT-FPIGYWPLPEPYWPDSKAITLPPRD 320
            ..:       ..|:.....||   ..|:|||:.:  .|| .|:|:||:||.:||:....:||||.
Mouse   251 MEL-------CRPSNLFAAQPWHSCHKLIYVRPN--SKTGVPVGHWPIPESFWPEQNLPSLPPRT 306

  Fly   321 AHPKLKVLTPAVD-EPQLVRSFPVDKYEIEGCPLTLQILNKREMNKCWQVIVTNGMHGFEL--PF 382
            :||.::.  ..|| ||.::...|.||||:|..|||..||.::..:.||||.||:.....||  ||
Mouse   307 SHPVVRF--SCVDCEPMVIDKLPFDKYELEPSPLTQYILERKSPHTCWQVFVTSSSKYNELGYPF 369

  Fly   383 GYLKAAPNFSQVHLYVLAYNYPALLPILHDLIHKYNMSPPSDLMYKFNAYVRSIPPYYCPFLRKA 447
            |||||:...:.|:|:|:.||||.|||:|.||...:.:.|.......|::|::::||||...|:||
Mouse   370 GYLKASTTLTCVNLFVMPYNYPVLLPLLDDLFKVHKLKPNLKWRQAFDSYLKTLPPYYLIPLKKA 434

  Fly   448 LVNINVPYQLLQFLLPENVDNYLSPTIANQLKHIKNTAKQDQENLCMKVYKQLKQPKPPYRQVET 512
            |..:..|.     |:.:|:|..||.::.:.||.:....|.:.:.:...|.|     |||.   |.
Mouse   435 LRMMGAPN-----LISDNLDCGLSYSVISYLKKLSQQTKLESDQILASVGK-----KPPQ---EI 486

  Fly   513 G-----KLFTGAPLRRDLVRHPLLRDIFSKLH---GEIDPVENYTIVVPQPTHQSSAKSHRNPFD 569
            |     ....|.||..:.....||::|..:..   .|::|.|.....|.........:::||.:|
Mouse   487 GIKVKNHSACGLPLAHNKSFRKLLKEIIGESAPRLTELNPKEFAGFQVGLLNKDLKPQTYRNAYD 551

  Fly   570 IPRRDLVEEIAKMRETLLRPVSLVA---KDSGHCLPIAEMGNYQEYLKNKDNPLREIEPTN-VRQ 630
            ||||.|::::.:||..||:....:.   :||.|.:|:|:|||||||||...:||||::|.. .|.
Mouse   552 IPRRGLLDQLTRMRSNLLQTRKFIVGQDEDSLHSVPVAQMGNYQEYLKMLASPLRELDPDQPKRL 616

  Fly   631 HMFGNPYKKDKHMVMVDEADLSDVAPMKSPNGNGPGGAPPGSPSGSGSPTGPGPSSPGSSPGGGS 695
            |.||||:|:||..:|:||||...|.|.....       .||.           |:||.||
Mouse   617 HTFGNPFKQDKKGMMIDEADEFVVGPQNKVK-------RPGE-----------PNSPMSS----- 658

  Fly   696 GPGMPGMPGMGGGMSGLMLGAGGSGGSSKKLDGTSRGRKRKAGPLPRSFEFRRSSTDSRSSSSGS 760
                                                 ::|::    .|...||:.|
Mouse   659 -------------------------------------KRRRS----MSLLLRRAQT--------- 673

  Fly   761 ESSTTGSAPGSPIPGATSSISGCDSAMGADGGPSSSCFDEDSNSN---------SSFVSSTSEA- 815
             :.|..:..|...|.:.|....|.|.:....|...:....|::..         ..|:..::.|
Mouse   674 -APTVTNHVGGKGPLSASWFPSCPSLVKHTFGHPDTTVIHDTHEEKMENGQSPPDGFLLKSAPAE 737

  Fly   816 --SASDSGMSNSHLDPLRISFVFIEEETSDQDTPLNGYVHNFINGISDDAETGETEAVPGGASLP 878
              :.|.....:|.||.|...|..:.::         |::|...|.|           :.|||...
Mouse   738 FMNVSGESFISSQLDSLSDDFTGLRKD---------GFIHKPGNNI-----------LLGGAKTC 782

  Fly   879 GASSANEPSSIGASPAVSATPATSVIPASNGSEVCSAVAAGSSSSI 924
            ..|.|::        .::...|...:|  |..::..|:|.|.::.|
Mouse   783 SLSVADQ--------KITMASALETVP--NSMQITPAMAQGINADI 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS6	NP_001259259.1	vWFA	4..>147	CDD:238119	88/142 (62%)
IntS6	NP_001259259.1	INT_SG_DDX_CT_C	1196..1257	CDD:291946
Ints6l	XP_006528039.1	VWA_2	4..132	CDD:379234	86/130 (66%)
Ints6l	XP_006528039.1	INT_SG_DDX_CT_C	816..875	CDD:373727	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850778
Domainoid	1	1.000	341	1.000	Domainoid score	I1081
eggNOG	1	0.900	-	-		E1_KOG3768
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H52110
Inparanoid	1	1.050	571	1.000	Inparanoid score	I1054
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D551849at2759
OrthoFinder	1	1.000	-	-		FOG0003020
OrthoInspector	1	1.000	-	-		otm44345
orthoMCL	1	0.900	-	-		OOG6_103620
Panther	1	1.100	-	-	O	PTHR12957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3035
SonicParanoid	1	1.000	-	-		X2010
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790