DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS6 and INTS6L

DIOPT Version :9

Sequence 1:	NP_001259259.1	Gene:	IntS6 / 31496	FlyBaseID:	FBgn0261383	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	NP_001338530.1	Gene:	INTS6L / 203522	HGNCID:	27334	Length:	898	Species:	Homo sapiens

Alignment Length:	865	Identity:	343/865 - (39%)
Similarity:	480/865 - (55%)	Gaps:	102/865 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTIILFLVDTSSSMCQKAYVNGVQKTYLDIAKGAVETFLKYRQRTQDCLGDRYMLLTFEEPPANV 65
            |.|:|||:|||:||.|:   ..:..:||||||||||.|||.|.|.....||||||:|::|||..:
Human     1 MPILLFLIDTSASMNQR---TDLGTSYLDIAKGAVELFLKLRARDPASRGDRYMLVTYDEPPYCI 62

  Fly    66 KAGWKENHATFMNELKNLQSHGLTSMGESLRNAFDLLNLNRMQSGIDTYGQGRCPFYLEPSVIIV 130
            ||||||||||||:||||||:.|||::|::||::||||||||:.||||.|||||.||:||||::|.
Human    63 KAGWKENHATFMSELKNLQASGLTTLGQALRSSFDLLNLNRLISGIDNYGQGRNPFFLEPSILIT 127

  Fly   131 ITDGGRYSYRNGVHQEIILPLSNQIPGTKFTKEPFRWDQRLFSLVLRMPGNKIDERVD-GKVPHD 194
            ||||.:.:...||.:|:.|||::.:||::.||||||||||||:||||:||....|... |.||.|
Human   128 ITDGNKLTSTAGVQEELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGVASTEPEQLGSVPTD 192

  Fly   195 DSPIERMCEVTGGRSYRVRSHYVLNQCIESLVQKVQPGVVLQFEPMLPKEATSATAGEAAGASTI 259
            :|.|.:||||||||||.||:..:||||:||||||||.|||:.||...|   .....||
Human   193 ESAITQMCEVTGGRSYCVRTQRMLNQCLESLVQKVQSGVVINFEKTGP---DPLPIGE------- 247

  Fly   260 SGMGISSTSGAGPAPDIVFQP---VKKMIYVQKHITQKT-FPIGYWPLPEPYWPDSKAITLPPRD 320
            .|:..||.    |:.....||   ..|:|||:.:  .|| .|:|:||:||.:|||....:||||.
Human   248 DGLMDSSR----PSNSFAAQPWHSCHKLIYVRPN--SKTGVPVGHWPIPESFWPDQNLPSLPPRT 306

  Fly   321 AHPKLKVLTPAVD-EPQLVRSFPVDKYEIEGCPLTLQILNKREMNKCWQVIVTNGMHGFEL--PF 382
            :||.::.  ..|| ||.::...|.||||:|..|||..||.::..:.||||.||:.....||  ||
Human   307 SHPVVRF--SCVDCEPMVIDKLPFDKYELEPSPLTQYILERKSPHTCWQVFVTSSGKYNELGYPF 369

  Fly   383 GYLKAAPNFSQVHLYVLAYNYPALLPILHDLIHKYNMSPPSDLMYKFNAYVRSIPPYYCPFLRKA 447
            |||||:...:.|:|:|:.||||.|||:|.||...:.:.|.......|::|::::||||...|:||
Human   370 GYLKASTTLTCVNLFVMPYNYPVLLPLLDDLFKVHKLKPNLKWRQAFDSYLKTLPPYYLLPLKKA 434

  Fly   448 LVNINVPYQLLQFLLPENVDNYLSPTIANQLKHIKNTAKQDQENLCMKVYKQLKQPKPPYRQVET 512
            |..:..|.     |:.:|:|..||.::.:.||.:....|.:.|.:...|.|     |||.   |.
Human   435 LRMMGAPN-----LISDNLDCGLSYSVISYLKKLSQQTKLESERILASVGK-----KPPQ---EI 486

  Fly   513 G---KLFTGAPLRRDLVRHPLLRDIFSKLHG-------EIDPVENYTIVVPQPTHQSSAKSHRNP 567
            |   |..:|..:  .|..:...|.:..::.|       |::..|.....:.........:::||.
Human   487 GIKVKNHSGGGM--SLTHNKNFRKLLKEITGETALRLTELNTKEFAGFQIGLLNKDLKPQTYRNA 549

  Fly   568 FDIPRRDLVEEIAKMRETLLRPVSLVA---KDSGHCLPIAEMGNYQEYLKNKDNPLREIEPTN-V 628
            :|||||.|::::.:||..||:....:.   :||.|.:|:|:|||||||||...:|||||:|.. .
Human   550 YDIPRRGLLDQLTRMRSNLLKTHKFIVGQDEDSLHSVPVAQMGNYQEYLKTLASPLREIDPDQPK 614

  Fly   629 RQHMFGNPYKKDKHMVMVDEADLSDVAPMKSPNGNGPGGAPPGSPSGSGSPTGPG-----PSSPG 688
            |.|.||||:|:||..:|:||||.....|.......|    .|.||..|.......     |.:|.
Human   615 RLHTFGNPFKQDKKGMMIDEADEFVAGPQNKVKRPG----EPNSPMSSKRRRSMSLLLRKPQTPP 675

  Fly   689 SSPG--GGSGP----GMPGMPGMGGGMSGLMLGAGGS---GGSSKKLDGTSRGRKRKAGPLPRSF 744
            :...  ||.||    ..|..|.:   :...::....:   .|..:|::   .|:....|.|
Human   676 TVTNHVGGKGPPSASWFPSYPNL---IKPTLVHTDATIIHDGHEEKME---NGQITPDGFL---- 730

  Fly   745 EFRRSSTDSRSSSSGSESSTTGSAPGSPIPGATSSISGCDSAMGADG---GPSSSCFDEDSNSNS 806
                    |:|:.|...:.|....|    |....|:|...:::..||   .|.|:.|...:.:.|
Human   731 --------SKSAPSELINMTGDLMP----PNQVDSLSDDFTSLSKDGLIQKPGSNAFVGGAKNCS 783

  Fly   807 SFVSSTSEASASDSG-MSNS 825
            ..|....:..||..| |.|:
Human   784 LSVDDQKDPVASTLGAMPNT 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS6	NP_001259259.1	vWFA	4..>147	CDD:238119	88/142 (62%)
IntS6	NP_001259259.1	INT_SG_DDX_CT_C	1196..1257	CDD:291946
INTS6L	NP_001338530.1	VWA_2	4..132	CDD:316077	85/130 (65%)
INTS6L	NP_001338530.1	INT_SG_DDX_CT_C	814..875	CDD:317673
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160427
Domainoid	1	1.000	338	1.000	Domainoid score	I1109
eggNOG	1	0.900	-	-		E1_KOG3768
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H52110
Inparanoid	1	1.050	568	1.000	Inparanoid score	I1074
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D551849at2759
OrthoFinder	1	1.000	-	-		FOG0003020
OrthoInspector	1	1.000	-	-		otm42293
orthoMCL	1	0.900	-	-		OOG6_103620
Panther	1	1.100	-	-	O	PTHR12957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3035
SonicParanoid	1	1.000	-	-		X2010
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790