DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS6 and ints6

DIOPT Version :9

Sequence 1:	NP_001259259.1	Gene:	IntS6 / 31496	FlyBaseID:	FBgn0261383	Length:	1284	Species:	Drosophila melanogaster
Sequence 2:	XP_002936771.3	Gene:	ints6 / 100496540	XenbaseID:	XB-GENE-967190	Length:	877	Species:	Xenopus tropicalis

Alignment Length:	899	Identity:	335/899 - (37%)
Similarity:	465/899 - (51%)	Gaps:	179/899 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTIILFLVDTSSSMCQKAYVNGVQKTYLDIAKGAVETFLKYRQRTQDCLGDRYMLLTFEEPPANV 65
            |.|:|||:|||:||.|:.::.   .|||||||||||||:|.|.|.....||||||:|.||||..:
Frog     1 MPILLFLLDTSASMNQRTHLG---TTYLDIAKGAVETFMKLRSRDPASRGDRYMLVTLEEPPYGI 62

  Fly    66 KAGWKENHATFMNELKNLQSHGLTSMGESLRNAFDLLNLNRMQSGIDTYGQGRCPFYLEPSVIIV 130
            |||||||||||||||||||:.|||::|:|||.|||||||||:.:|||.|||||.||:||||:||.
Frog    63 KAGWKENHATFMNELKNLQAVGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQGRNPFFLEPSIIIA 127

  Fly   131 ITDGGRYSYRNGVHQEIILPLSNQIPGTKFTKEPFRWDQRLFSLVLRMPG-NKIDERVDGKVPHD 194
            ||||.:.:..||...|:.|||.:.:||::.||||||||||||:||||:|| :.:::.....|..|
Frog   128 ITDGSKLTTANGAQDELHLPLISPLPGSELTKEPFRWDQRLFALVLRLPGASSVEQEQPTAVQFD 192

  Fly   195 DSPIERMCEVTGGRSYRVRSHYVLNQCIESLVQKVQPGVVLQFE------PMLPKEATSATAGEA 253
            :|||..||:|||||||.|.|..:||||:||||||:|.|||:.||      |:|....|.
Frog   193 ESPITAMCDVTGGRSYSVTSQRILNQCLESLVQKIQSGVVINFEKSGPDPPILEDGPTD------ 251

  Fly   254 AGASTISGMGISSTSGAGPAPDIVFQP---VKKMIYVQKHITQKTFPIGYWPLPEPYWPDSKAIT 315
                              |...:..||   .:|:|||:.: .:...|:|:||:||.:|||..:.|
Frog   252 ------------------PVRSVGSQPWHSCRKLIYVRPN-PKAGVPLGHWPIPESFWPDQNSPT 297

  Fly   316 LPPRDAHPKLKVLTPAVDEPQLVRSFPVDKYEIEGCPLTLQILNKREMNKCWQVIVTNGMHGFEL 380
            ||||.:||.:| .:....||.::...|.||||:|..|||..||.::..:.||.|.|.|.....||
Frog   298 LPPRTSHPVVK-FSCTDSEPMVIDKLPFDKYELEPSPLTQFILERKSPHTCWTVFVANSAKYSEL 361

  Fly   381 --PFGYLKAAPNFSQVHLYVLAYNYPALLPILHDLIHKYNMSPPSDLMYKFNAYVRSIPPYYCPF 443
              |||||||:...|.|:|:||.||||.|||:|.||...:...||......|..|::::||||...
Frog   362 GHPFGYLKASTALSCVNLFVLPYNYPVLLPLLDDLFKIHKNKPPLKWRQLFENYLKTMPPYYIGP 426

  Fly   444 LRKALVNINVPYQLLQFLLPENVDNYLSPTIANQLKHIKNTAKQDQENLCMKVYKQLKQPKPPYR 508
            |:|||..:..|.     |:|::::..||.::.:.||.:...||.:.:.:...:.|  |.|:....
Frog   427 LKKALRMMGAPN-----LMPDSMEYGLSYSVVSYLKKLSQQAKIESDRVIGLIGK--KFPQETGI 484

  Fly   509 QVETGKLFTGAPLRRDLVRHPLLRDIFSKLHGEIDPVENYTIVVPQPTHQSSAK----------- 562
            :|.:|.......||:|      .:.:..::.||          |||.....:.|
Frog   485 KVRSGSNALSLALRKD------FKQLLQEITGE----------VPQRPMDLNMKEFAGFQIALLN 533

  Fly   563 ------SHRNPFDIPRRDLVEEIAKMRETLLRPVSLVAK----DSGHCLPIAEMGNYQEYLKNKD 617
                  :.||.:||||.:|::.:.:||..||:......|    |..|.:||.:|||||||||:..
Frog   534 KDIKPQTFRNAYDIPRTNLLDHLTRMRANLLKSTRQFLKGQDEDQAHSIPIVQMGNYQEYLKHIP 598

  Fly   618 NPLREIEPTNVRQ-HMFGNPYKKDKHMVMVDEADLSDVAPMKSPNGNGPGGAPPGSPSGSGSPTG 681
            :|||||:....|: |.||||:|.||..:|:||||       :..:||          ......||
Frog   599 SPLREIDSDQPRRLHTFGNPFKLDKKGMMIDEAD-------EFVSGN----------QNKQKRTG 646

  Fly   682 PGPSSPGSSPGGGSGPGMPGMPGMGGGMSGLMLGAGGSGGSSKKLDGTSRGRKRKAGPLPRSFEF 746
            .              |.|.|:|                            .|:|...||.||
Frog   647 E--------------PNMQGVP----------------------------KRRRCMSPLLRS--- 666

  Fly   747 RRSSTDSRSSSSGSESSTTGSAPGSPIPGATSSISGCDSAMGADGGPSSSCFDEDSNSN------ 805
            |..|....::..|.:.......| .|:            |:..:..||::....::..|
Frog   667 RPQSPSVINNHIGGKDQVPPDLP-KPV------------AVHKNSDPSNNVAMNEATENHVADHL 718

  Fly   806 -SSFVSSTSE--ASASDSGMS---------NSHLDPLRISFVFIEEETSDQDTP 847
             ...|::.||  .:.||:.:.         :.:..|...|.||:|:.....|||
Frog   719 RDDLVTTKSEPFETLSDAAVEATEAYAAARDCNFTPNDTSDVFLEKTKDSGDTP 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS6	NP_001259259.1	vWFA	4..>147	CDD:238119	93/142 (65%)
IntS6	NP_001259259.1	INT_SG_DDX_CT_C	1196..1257	CDD:291946
ints6	XP_002936771.3	VWA_2	4..131	CDD:379234	89/129 (69%)
ints6	XP_002936771.3	INT_SG_DDX_CT_C	800..858	CDD:373727
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	356	1.000	Domainoid score	I983
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	583	1.000	Inparanoid score	I993
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D551849at2759
OrthoFinder	1	1.000	-	-		FOG0003020
OrthoInspector	1	1.000	-	-		otm49523
Panther	1	1.100	-	-	LDO	PTHR12957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3035
SonicParanoid	1	1.000	-	-		X2010
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.100