Protein Alignment Snx27 and SNX17

DIOPT Version :10

• Sequence 1: NP_727023.1
• Gene: Snx27 / 31493
• FlyBaseID: FBgn0052758
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_055563.1
• Gene: SNX17 / 9784
• HGNCID: 14979
• Length: 470
• Species: Homo sapiens
• Alignment Length: 397
• Identity: 101/397 - (25%)
• Similarity: 171/397 - (43%)
• Gaps: 48/397 - (12%)

  Fly   171 SIPDYGIVNRNGE----RYIVFNIHMAGRQLCSRRYREFANLHSLLRKEFSGFNFPKLPGKWPFQ 231
            |||:  ..:|:|:    .|:.:|||:.|...|..||.:...||..||||:.....|..|.|..|.
Human     4 SIPE--TESRSGDSGGSAYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFS 66

  Fly   232 LSEQQLDTRRRGLEQYLEKVCAVRVIAESDAVQDFLTDTEDDISASP---VDIKVMLPDHEVSTV 293
            |:..:::.||..||:|::.|....::..|:....||...:.:....|   |.::|:|.:.:...|
Human    67 LTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSNGQKVLV 131

  Fly   294 SVKKSSNAQVVWEILVQRANLTAYTQQYFYLFEIVE-----YNFERKLQPHEIPH----QLYVQN 349
            :|..|...:.|.|.:..:.:|......||.||.:.|     ::|.||||..|:|:    .|..|.
Human   132 NVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQE 196

  Fly   350 YSTASSTCLCVRRWLFSVAKELTLPDGEQAGRFIFYQAVDEVNRGNIRADGRLY-ELKALQDAKK 413
            |.      :.:|:..:..|.:..:.:.......::.|.|.::.||.|......: :||:||:...
Human   197 YK------IVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIERGWILVTKEQHRQLKSLQEKVS 255

  Fly   414 AGDYLALARTLPGYGDVVFPHCSCD-SRKEGHVVPAVGMKSFRL------HACREDGSLEAQMVE 471
            ..::|.||:||..||.:.|..|..| ..|:..||.:.|.....|      ...|| ||.....:.
Human   256 KKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLRE-GSFRVTRMR 319

  Fly   472 LTWDSITRS-------------ESDEESMSFCFQYNRPDKPARWVKVYTPYHAFLADCFDRIMEE 523
             .| .:|.|             ...|..:...|:|.......:||.:.:|....::.|...:::|
Human   320 -CW-RVTSSVPLPSGSTSSPGRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDE 382

  Fly   524 RKWEDSG 530
            ...:.||
Human   383 LMVKKSG 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snx27	NP_727023.1	PDZ_SNX27-like	47..139	CDD:467283
		PX_SNX27	165..270	CDD:132796	33/102 (32%)
		FERM_F1_SNX27	277..368	CDD:340475	26/102 (25%)
		FERM-like_C_SNX27	428..528	CDD:270146	24/119 (20%)
SNX17	NP_055563.1	PX_SNX17_31	2..106	CDD:132795	33/103 (32%)
		FERM-like. /evidence=ECO:0000269|PubMed:39587083	115..432		67/284 (24%)
		FERM_F1_SNX17	115..207	CDD:340538	25/97 (26%)
		FERM-like_C_SNX17	269..388	CDD:270145	25/121 (21%)
		PTB-like F3 module	270..432		26/123 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	401..426
		Interacts with the retriever complex. /evidence=ECO:0000269|PubMed:39587083	458..470