DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Snx27 and SNX25

DIOPT Version :9

Sequence 1:	NP_727023.1	Gene:	Snx27 / 31493	FlyBaseID:	FBgn0052758	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001364961.1	Gene:	SNX25 / 83891	HGNCID:	21883	Length:	1037	Species:	Homo sapiens

Alignment Length:	275	Identity:	57/275 - (20%)
Similarity:	106/275 - (38%)	Gaps:	77/275 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 INGELYAPL------QHVSAVLEN----GAAEKAGIKKGD---------------RILEVNGV-- 112
            |..:||..|      :|.|.::.|    |..::||.:..|               ::.|:|..
Human   589 IVSDLYEKLLIKEEEKHASQMISNKDEMGPRDEAGEEAVDDGTNQINEQASFAVNKLRELNEKLE 653

  Fly   113 -------SVEGA--THKQVVDLIKSGGDCLTLTVISVTQQEADRLEPQEDQSGYSYIDY--SDKR 166
                   |::.|  ..|::|..:|.       .:|.:.::..|.      |...:..|:  .:..
Human   654 YKRQALNSIQNAPKPDKKIVSKLKD-------EIILIEKERTDL------QLHMARTDWWCENLG 705

  Fly   167 SLPISIPDYGIVNRNGER----YIVFNIHMAG-----RQLCSRRYREFANLHSLLRKEFSGFNFP 222
            ....||....:...|||:    :::.::...|     .....||..||.|||..|.:........
Human   706 MWKASITSGEVTEENGEQLPCYFVMVSLQEVGGVETKNWTVPRRLSEFQNLHRKLSECVPSLKKV 770

  Fly   223 KLP--GKWPFQLSEQQ-LDTRRRGLEQYLEKVCAVRVIAESDAVQDFLTDTEDDISASPVDIKVM 284
            :||  .|.||:..:|: ::..:..|.::|:.:.:...:.:|:|:..||       |.||..:||:
Human   771 QLPSLSKLPFKSIDQKFMEKSKNQLNKFLQNLLSDERLCQSEALYAFL-------SPSPDYLKVI 828

  Fly   285 LPDHEVSTVSVKKSS 299
                   .|..||:|
Human   829 -------DVQGKKNS 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx27	NP_727023.1	PDZ_signaling	46..138	CDD:238492	18/98 (18%)
		PX_SNX27	165..270	CDD:132796	26/116 (22%)
		UBQ	278..363	CDD:294102	7/22 (32%)
		FERM-like_C_SNX27	428..528	CDD:270146
SNX25	NP_001364961.1	PXA	166..321	CDD:396666
		235kDa-fam	<331..>691	CDD:130673	20/114 (18%)
		RGS_SNX25	488..596	CDD:188675	3/6 (50%)
		PX_SNX25	699..821	CDD:132788	27/128 (21%)
		Nexin_C	898..1004	CDD:400794
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1370
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030