Protein Alignment Snx27 and SNX27

DIOPT Version :9

• Sequence 1: NP_727023.1
• Gene: Snx27 / 31493
• FlyBaseID: FBgn0052758
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_001317652.1
• Gene: SNX27 / 81609
• HGNCID: 20073
• Length: 541
• Species: Homo sapiens
• Alignment Length: 525
• Identity: 280/525 - (53%)
• Similarity: 389/525 - (74%)
• Gaps: 10/525 - (1%)

  Fly     5 GEN-HPLPTPTPASAVVTASSGGGGGGAVVMGVGVGVTTANGPRVVTIYKTETGFGFNVRGQVSE 68
            ||. ||       ||......||||||:.:...|.|.....|||||.|.|:|:|:||||||||||
Human     6 GEGIHP-------SAPHRNGGGGGGGGSGLHCAGNGGGGGGGPRVVRIVKSESGYGFNVRGQVSE 63

  Fly    69 GGQLRSINGELYAPLQHVSAVLENGAAEKAGIKKGDRILEVNGVSVEGATHKQVVDLIKSGGDCL 133
            ||||||||||||||||||||||..|||::||::|||||||||.|:|||||||||||||::|...|
Human    64 GGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDRILEVNHVNVEGATHKQVVDLIRAGEKEL 128

  Fly   134 TLTVISVTQQEADRLEPQEDQSGYSYIDYSDKRSLPISIPDYGIVNRNGERYIVFNIHMAGRQLC 198
            .|||:||...|||.|:|.:|..|.|:.||::|:::|||:|.|..|.:|||:::|:|::|||||||
Human   129 ILTVLSVPPHEADNLDPSDDSLGQSFYDYTEKQAVPISVPRYKHVEQNGEKFVVYNVYMAGRQLC 193

  Fly   199 SRRYREFANLHSLLRKEFSGFNFPKLPGKWPFQLSEQQLDTRRRGLEQYLEKVCAVRVIAESDAV 263
            |:||||||.||..|::||:.|.||:|||||||.|||||||.||||||:||||||::|||.|||.:
Human   194 SKRYREFAILHQNLKREFANFTFPRLPGKWPFSLSEQQLDARRRGLEEYLEKVCSIRVIGESDIM 258

  Fly   264 QDFLTDTEDDIS-ASPVDIKVMLPDHEVSTVSVKKSSNAQVVWEILVQRANLTAYTQQYFYLFEI 327
            |:||::::::.: .|.|:::|.|||....||.|||:|....|::.:..:..:.:.|..||.|||:
Human   259 QEFLSESDENYNGVSDVELRVALPDGTTVTVRVKKNSTTDQVYQAIAAKVGMDSTTVNYFALFEV 323

  Fly   328 VEYNFERKLQPHEIPHQLYVQNYSTA-SSTCLCVRRWLFSVAKELTLPDGEQAGRFIFYQAVDEV 391
            :.::|.|||.|:|.||:||:|||::| ..|||.:|:|||:..:|:.|.|.:.|..:.|:||||:|
Human   324 ISHSFVRKLAPNEFPHKLYIQNYTSAVPGTCLTIRKWLFTTEEEILLNDNDLAVTYFFHQAVDDV 388

  Fly   392 NRGNIRADGRLYELKALQDAKKAGDYLALARTLPGYGDVVFPHCSCDSRKEGHVVPAVGMKSFRL 456
            .:|.|:|:.:.|:|:.|.:.:|...||.:.||..||.:::||||:||||::|||:.|:.:..|:|
Human   389 KKGYIKAEEKSYQLQKLYEQRKMVMYLNMLRTCEGYNEIIFPHCACDSRRKGHVITAISITHFKL 453

  Fly   457 HACREDGSLEAQMVELTWDSITRSESDEESMSFCFQYNRPDKPARWVKVYTPYHAFLADCFDRIM 521
            |||.|:|.||.|::...||.:.|.::|||.|:|||:|.|.:|..||||::|||..::.:||:|:.
Human   454 HACTEEGQLENQVIAFEWDEMQRWDTDEEGMAFCFEYARGEKKPRWVKIFTPYFNYMHECFERVF 518

  Fly   522 EERKW 526
            .|.||
Human   519 CELKW 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snx27	NP_727023.1	PDZ_signaling	46..138	CDD:238492	72/91 (79%)
		PX_SNX27	165..270	CDD:132796	69/104 (66%)
		UBQ	278..363	CDD:294102	36/85 (42%)
		FERM-like_C_SNX27	428..528	CDD:270146	48/99 (48%)
SNX27	NP_001317652.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..42		15/42 (36%)
		PDZ_signaling	41..133	CDD:238492	72/91 (79%)
		PX_SNX27	160..265	CDD:132796	69/104 (66%)
		FERM_F1_SNX27	273..365	CDD:340475	40/91 (44%)
		FERM-like region F1	273..362		38/88 (43%)
		FERM-like region F2	373..421		17/47 (36%)
		FERM-like_C_SNX27	425..526	CDD:270146	48/99 (48%)
		FERM-like region F3	425..525		48/99 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146027
Domainoid	1	1.000	177	1.000	Domainoid score	I3609
eggNOG	1	0.900	-	-		E1_KOG3784
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12797
Inparanoid	1	1.050	591	1.000	Inparanoid score	I985
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52273
OrthoDB	1	1.010	-	-		D193838at33208
OrthoFinder	1	1.000	-	-		FOG0006537
OrthoInspector	1	1.000	-	-		oto91504
orthoMCL	1	0.900	-	-		OOG6_107041
Panther	1	1.100	-	-	LDO	PTHR12431
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1370
SonicParanoid	1	1.000	-	-		X4771
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.800