Protein Alignment Snx27 and Snx27

DIOPT Version :10

• Sequence 1: NP_727023.1
• Gene: Snx27 / 31493
• FlyBaseID: FBgn0052758
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_001075953.1
• Gene: Snx27 / 76742
• MGIID: 1923992
• Length: 539
• Species: Mus musculus
• Alignment Length: 807
• Identity: 157/807 - (19%)
• Similarity: 285/807 - (35%)
• Gaps: 227/807 - (28%)

  Fly    69 SNTESKNAGSENPGSSETSADQTANEPKPDKVSD--DNAGSAETIESNGIEKIPSNDTS-SPIFD 130
            |..|:.....|..|:...||:....|.|.:|..|  :|...|...|...:..|...::| :|
Mouse   546 STAETDGDELEIKGAEVDSAEDILEEQKVEKTVDGSENDAVASVEEEKAVVDIVDEESSHTP--- 607

  Fly   131 SAVVPSGPAQEEDEAVEEEKKVEEEHENHGNSEDAEENKSGDAVTTTTELSMEDREGNDDPKDES 195
             .|.....|:|:||...:..::..:.::..::.|:|..:..:.|.:.:|:..|:....:..:|.|
Mouse   608 -EVTDEEMAKEKDEDTSDSTEMTSDVQDIDDTIDSETEEIPEMVESVSEVGEEEPFVIEKVEDTS 671

  Fly   196 ESGTTVSN---------NEETTTTE--------NKVADEAPSK------EAESIQASQDS----- 232
            :|....||         |.:..|.|        :.|.:|.||:      ..|.::.:.||
Mouse   672 DSKEITSNAADVQDVDDNSDVDTEEIPELVGGVSDVGEEEPSEVIDEEIATEKLEDASDSTGLIP 736

  Fly   233 ---------DHVEKEGE-SETTTTSDESATTTEKKTNGAEL-----VEKSE-----TEEKNGDSS 277
                     |.:|.:.| :|..|..|.|..|.|:.::..|:     ||||:     .|:|..:..
Mouse   737 SAENVKDTDDILEVDAEVNEVETVEDISEVTNEETSDVPEVIDEEKVEKSDDIFHFAEDKPTELI 801

  Fly   278 TKSPEVT-------SESSVDTTTIEE-QLKSNNDEEKQVDGNEKESTF-----RVLNEDHNENEE 329
            :.:|:||       |..|.|..||:| .:....|||.:.:..::.|.|     ..:..|..:.:|
Mouse   802 SDAPDVTEDIEISISAVSEDNETIQEADMTDVKDEEMEAEKVDEISYFVEDKSTEITSDATDVKE 866

  Fly   330 IGEGTKKVTEETTTVETTERQ------NVDDTTENQTTQT----TSSSYNAKEEKKSYRKCKVEE 384
            ..:|. .||||..|:|:.:..      |.||...|.|...    ||...:..:|.:
Mouse   867 DTDGF-TVTEEKGTIESLQEAAMKMSGNADDEIPNVTEMVEEPDTSDVMDELDEPE--------- 921

  Fly   385 WNDVTTVEVPNQSV--------------------HKKLLLDMDSE-------------------- 409
             .|...:.|.|:.|                    |.||....|||
Mouse   922 -KDEDVISVTNERVTTAQDVIFSKEKMGAAELDDHDKLRAKDDSEVDHMEKEIADAENDLQNEID 985

  Fly   410 -DE--TENIQHKPRIISAFAYK-------DSIAVTLSAK----------NFSSETVYCRYHDCYK 454
             ||  .|:..|:..:.|..|.:       |...|.|:.|          |.:::    |..|...
Mouse   986 KDEFKVEDASHQTILGSTAAEEDQDDDDDDEEPVLLTVKHELTDGDDENNNNND----RKRDART 1046

  Fly   455 KGMGDPKPSFVYPES-TVYCPRRAGAKYISISETLDTIGQYPVQIVKRQRPEHFLTVCVPLNDEN 518
            ||:.:.|.    |:| :.....:...|.:. .|:...:.|......|:.| |....:...:.:|.
Mouse  1047 KGLINRKT----PKSHSTETDEQKAHKDLH-KESAKVLEQVKEAKEKKAR-EEIYKIIQEMREEK 1105

  Fly   519 VNILEVARFIEYYKLQGATFFNVYYKNMSKYQTMLLEDYT-------KTGDVKLVK--------- 567
            ...:|     |...||.   .|:..:.:.|.:|:..|:..       |..|.|:.|
Mouse  1106 AEGVE-----EEIVLQQ---INITVEKVKKEETVKKEEKAKRKEKAHKPKDAKIAKDKPKAVPVK 1162

  Fly   568 ----VGSEST---------------------EQIEANDCQHRSKYFSKWTAFLALNDRLEVGDGA 607
                |..:.|                     ::.:|.|.:.::|...|.....|:.::.:  ...
Mouse  1163 QEDEVAKKETKPAPSKKEAKIVKEKPKAHPAKKEKAKDIKEKAKSGQKEKVAEAVKEKSK--PVK 1225

  Fly   608 KEGTTIASKIDSVVDFKLNVLKYTSPETDEKIRIV----VRPDKIVSINQHPILVYSDDQPQEAI 668
            ||...|.:|:....:.|::......|:..::..::    :.|::            .:.:..:|.
Mouse  1226 KEAEKIDAKVKPAAEKKVDEAPKEKPKVKKEAEVIKKIKLEPER------------KEAKTPKAK 1278

  Fly   669 AESSGLLKEFINSDDKWTPENLSENIE 695
            .|.:||.|:...:.:|..|..:.:..|
Mouse  1279 IEPAGLKKDAEAAKEKAKPAPVKKGPE 1305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snx27	NP_727023.1	PDZ_SNX27-like	47..139	CDD:467283	17/72 (24%)
		PX_SNX27	165..270	CDD:132796	33/152 (22%)
		FERM_F1_SNX27	277..368	CDD:340475	30/113 (27%)
		FERM-like_C_SNX27	428..528	CDD:270146	20/117 (17%)
Snx27	NP_001075953.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40
		PDZ_SNX27-like	40..132	CDD:467283
		PX_SNX27	158..263	CDD:132796
		FERM_F1_SNX27	271..363	CDD:340475
		FERM-like region F1. /evidence=ECO:0000250	271..360
		FERM-like region F2. /evidence=ECO:0000250	371..419
		FERM-like_C_SNX27	423..524	CDD:270146
		FERM-like region F3. /evidence=ECO:0000250	423..523