DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snx27 and Snx31

DIOPT Version :9

Sequence 1:	NP_727023.1	Gene:	Snx27 / 31493	FlyBaseID:	FBgn0052758	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001333951.1	Gene:	Snx31 / 66696	MGIID:	1913946	Length:	439	Species:	Mus musculus

Alignment Length:	372	Identity:	94/372 - (25%)
Similarity:	165/372 - (44%)	Gaps:	39/372 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 GERYIVFNIHMAGRQLCSRRYREFANLHSLLRKEFSGFNFPKLPGKWPFQLSEQQLDTRRRGLEQ 246
            |.||:::::::.|...|..||.:.......||:.| |...|..|.|:...::....:.||..||:
Mouse    18 GGRYVLYSVYLDGFLFCKVRYSQLHRWDEQLRRVF-GNCLPPFPPKYYLAMTTAMAEERRDQLER 81

  Fly   247 YLEKVCAVRVIAESDAVQDFLTDTE---DDISASPVDIKVMLPDHEVSTVSVKKSSNAQVVWEIL 308
            ||:.|.|...:..||...:|||..:   .:|:...|::.|.|||.....|....|..|:.|.|::
Mouse    82 YLQNVTADPRVTRSDVFTEFLTLVQLHTLNITIQNVELAVFLPDGRSIKVEGLTSDTAERVLEVM 146

  Fly   309 VQRANLTAYTQQYFYLFEIV-----EYNFERKLQPHEIPHQLYVQNYSTASSTC-LCVRRWLFSV 367
            ..:..|......||.||.|.     :.:..:||...|:|   |....|:....| :.:|:|....
Mouse   147 AHKLGLQPDLVGYFGLFLIQCFPEGKLSVVKKLADFELP---YTSLQSSEMENCKIGLRKWYLDP 208

  Fly   368 AKELTLPDGEQAGRFIFYQAVDEVNRGNIR-ADGRLYELKALQDAKKAGDYLALARTLPGYGDVV 431
            |.:..|.|...||..::.|||.::.:..:: ...:..||||||..:....:|.|::.:..||.|.
Mouse   209 ALDSMLMDCRAAGDLLYMQAVQDIEKEWMKPTQAQREELKALQKKENQTKFLELSQEVRHYGYVQ 273

  Fly   432 FPHCSCDSRKEGHVVPAVGMK----SFRLHAC--REDGSLEAQMVELT----WDSI---TRSESD 483
            ...|:|:     |..|..|.:    :..:..|  ..:|.::....:::    |...   |..::|
Mouse   274 LDPCTCN-----HPEPGCGAQLSIGNNEISCCITLPNGQIQDIAFQMSRVKCWQVTFLGTLLDTD 333

  Fly   484 ------EESMSFCFQYNRPDKPARWVKVYTPYHAFLADCFDRIMEER 524
                  .:::...|||:. |...:|..:||....||:.|..:::.||
Mouse   334 GPQRTLNQNLELRFQYSE-DSCQQWFVIYTKQAFFLSSCLKKMISER 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx27	NP_727023.1	PDZ_signaling	46..138	CDD:238492
		PX_SNX27	165..270	CDD:132796	27/87 (31%)
		UBQ	278..363	CDD:294102	24/90 (27%)
		FERM-like_C_SNX27	428..528	CDD:270146	24/116 (21%)
Snx31	NP_001333951.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	384..409
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3784
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810