DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Snx27 and Snx17

DIOPT Version :9

Sequence 1:	NP_727023.1	Gene:	Snx27 / 31493	FlyBaseID:	FBgn0052758	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_710147.1	Gene:	Snx17 / 266781	MGIID:	2387801	Length:	470	Species:	Mus musculus

Alignment Length:	396	Identity:	102/396 - (25%)
Similarity:	172/396 - (43%)	Gaps:	46/396 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 SIPDYGIVNRNGE----RYIVFNIHMAGRQLCSRRYREFANLHSLLRKEFSGFNFPKLPGKWPFQ 231
            |||:  ..:|:|:    .|:.:|||:.|...|..||.:...||..||||:.....|..|.|..|.
Mouse     4 SIPE--TESRSGDSGGSAYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVVPAFPPKKLFS 66

  Fly   232 LSEQQLDTRRRGLEQYLEKVCAVRVIAESDAVQDFLTDTEDDISASP---VDIKVMLPDHEVSTV 293
            |:..:::.||..||:|::.|....::..|:....||...:.:....|   |.::|:|.:.:...|
Mouse    67 LTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSNGQKVLV 131

  Fly   294 SVKKSSNAQVVWEILVQRANLTAYTQQYFYLFEIVE-----YNFERKLQPHEIPH----QLYVQN 349
            :|..|...:.|.|.:..:.:|......||.||.:.|     ::|.||||..|:|:    .|..|.
Mouse   132 TVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQE 196

  Fly   350 YSTASSTCLCVRRWLFSVAKELTLPDGEQAGRFIFYQAVDEVNRGNIRADGRLY-ELKALQDAKK 413
            |.      :.:|:..:..|.:..:.:.......::.|.|.::..|.|......: :||:||:...
Mouse   197 YK------IVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIEHGWILVTKEQHRQLKSLQEKVS 255

  Fly   414 AGDYLALARTLPGYGDVVFPHCSCD-SRKEGHVVPAVGMKSFRL------HACREDGSLEAQMVE 471
            ..::|.||:||..||.:.|..|..| ..|:..||.:.|.....|      ...|| ||.....:.
Mouse   256 KKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLRE-GSFRVTRMR 319

  Fly   472 LTW---DSI------TRSES---DEESMSFCFQYNRPDKPARWVKVYTPYHAFLADCFDRIMEER 524
             .|   .|:      |.|.|   .|..:...|:|.......:||.:.:|....::.|...:::|.
Mouse   320 -CWRVTSSVPLPSGGTSSPSRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDEL 383

  Fly   525 KWEDSG 530
            ..:.||
Mouse   384 MVKKSG 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx27	NP_727023.1	PDZ_signaling	46..138	CDD:238492
		PX_SNX27	165..270	CDD:132796	33/102 (32%)
		UBQ	278..363	CDD:294102	26/96 (27%)
		FERM-like_C_SNX27	428..528	CDD:270146	26/118 (22%)
Snx17	NP_710147.1	PX_SNX17_31	2..106	CDD:132795	33/103 (32%)
		FERM-like. /evidence=ECO:0000250	115..432		68/283 (24%)
		UBQ	116..>186	CDD:294102	20/69 (29%)
		FERM-like_C_SNX17	269..388	CDD:270145	27/120 (23%)
		PTB-like F3 module. /evidence=ECO:0000250	270..432		28/122 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..426
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3784
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810