DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Snx27 and Snx27

DIOPT Version :9

Sequence 1:	NP_727023.1	Gene:	Snx27 / 31493	FlyBaseID:	FBgn0052758	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001103621.1	Gene:	Snx27 / 260323	RGDID:	628705	Length:	539	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	276/505 - (54%)
Similarity:	385/505 - (76%)	Gaps:	2/505 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SGGGGGGAVVMGVGVGVTTANGPRVVTIYKTETGFGFNVRGQVSEGGQLRSINGELYAPLQHVSA 88
            :||||||:.:...|.|.....|||||.|.|:|:|:||||||||||||||||||||||||||||||
  Rat    17 NGGGGGGSGLHCAGNGGGGGGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSA 81

  Fly    89 VLENGAAEKAGIKKGDRILEVNGVSVEGATHKQVVDLIKSGGDCLTLTVISVTQQEADRLEPQED 153
            ||..|||::||::|||||||||||:|||||||||||||::|...|.|||:||...|||.|:|.:|
  Rat    82 VLPGGAADRAGVRKGDRILEVNGVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNLDPSDD 146

  Fly   154 QSGYSYIDYSDKRSLPISIPDYGIVNRNGERYIVFNIHMAGRQLCSRRYREFANLHSLLRKEFSG 218
            ..|.|:.||::|:::|||:|.|..|.:|||:::|:|::||||||||:||||||.||..|::||:.
  Rat   147 SLGQSFYDYTEKQAVPISVPTYKHVEQNGEKFVVYNVYMAGRQLCSKRYREFAILHQNLKREFAN 211

  Fly   219 FNFPKLPGKWPFQLSEQQLDTRRRGLEQYLEKVCAVRVIAESDAVQDFLTDTEDDIS-ASPVDIK 282
            |.||:|||||||.|||||||.||||||:||||||::|||.|||.:|:||::::::.: .|.|:::
  Rat   212 FTFPRLPGKWPFSLSEQQLDARRRGLEEYLEKVCSIRVIGESDIMQEFLSESDENYNGVSDVELR 276

  Fly   283 VMLPDHEVSTVSVKKSSNAQVVWEILVQRANLTAYTQQYFYLFEIVEYNFERKLQPHEIPHQLYV 347
            |.|||....||.|||:|....|::.:..:..:.:.|..||.|||::.::|.|||.|:|.||:|||
  Rat   277 VALPDGATVTVRVKKNSTTDQVYQAIAAKVGMDSTTVNYFALFEVINHSFVRKLAPNEFPHKLYV 341

  Fly   348 QNYSTA-SSTCLCVRRWLFSVAKELTLPDGEQAGRFIFYQAVDEVNRGNIRADGRLYELKALQDA 411
            |||::| ..|||.:|:|||:..:|:.|.|.:.|..:.|:||||:|.:|.|:|:.:.|:|:.|.:.
  Rat   342 QNYTSAVPGTCLTIRKWLFTTEEEVLLNDNDLAVTYFFHQAVDDVKKGYIKAEEKSYQLQKLYEQ 406

  Fly   412 KKAGDYLALARTLPGYGDVVFPHCSCDSRKEGHVVPAVGMKSFRLHACREDGSLEAQMVELTWDS 476
            :|...||.:.||..||.:::||||:||||::|||:.|:.:..|:||||.|:|.||.|::...||.
  Rat   407 RKMVMYLNMLRTCEGYNEIIFPHCACDSRRKGHVITAISITHFKLHACTEEGQLENQVIAFEWDE 471

  Fly   477 ITRSESDEESMSFCFQYNRPDKPARWVKVYTPYHAFLADCFDRIMEERKW 526
            :.|.::|||.|:|||:|.|.:|..||||::|||..::.:||:|:..|.||
  Rat   472 MQRWDTDEEGMAFCFEYARGEKKPRWVKIFTPYFNYMHECFERVFCELKW 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx27	NP_727023.1	PDZ_signaling	46..138	CDD:238492	73/91 (80%)
		PX_SNX27	165..270	CDD:132796	69/104 (66%)
		UBQ	278..363	CDD:294102	37/85 (44%)
		FERM-like_C_SNX27	428..528	CDD:270146	48/99 (48%)
Snx27	NP_001103621.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		9/22 (41%)
		PDZ_signaling	39..131	CDD:238492	73/91 (80%)
		PX_SNX27	158..263	CDD:132796	69/104 (66%)
		FERM_F1_SNX27	271..363	CDD:340475	40/92 (43%)
		FERM-like region F1. /evidence=ECO:0000250	271..360		40/89 (45%)
		FERM-like region F2. /evidence=ECO:0000250	371..419		18/47 (38%)
		FERM-like_C_SNX27	423..524	CDD:270146	48/97 (49%)
		FERM-like region F3. /evidence=ECO:0000250	423..523		48/97 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339766
Domainoid	1	1.000	177	1.000	Domainoid score	I3505
eggNOG	1	0.900	-	-		E1_KOG3784
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12797
Inparanoid	1	1.050	595	1.000	Inparanoid score	I928
OMA	1	1.010	-	-		QHG52273
OrthoDB	1	1.010	-	-		D193838at33208
OrthoFinder	1	1.000	-	-		FOG0006537
OrthoInspector	1	1.000	-	-		oto98581
orthoMCL	1	0.900	-	-		OOG6_107041
Panther	1	1.100	-	-	LDO	PTHR12431
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4771
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770