DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Snx27 and Snx14

DIOPT Version :9

Sequence 1:	NP_727023.1	Gene:	Snx27 / 31493	FlyBaseID:	FBgn0052758	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001346887.2	Gene:	Snx14 / 244962	MGIID:	2155664	Length:	946	Species:	Mus musculus

Alignment Length:	329	Identity:	71/329 - (21%)
Similarity:	114/329 - (34%)	Gaps:	120/329 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 QVSEGGQLRSINGE----LYAPLQHVSAVLEN------------------GA------------- 94
            :::||..:..:..:    |:...:||.::|||                  ||
Mouse   421 RIAEGPYIDVVKLQTMRCLFEAYEHVLSLLENVFTPMFCHSDEYFRQLLRGAESPTRNSKFNRGS 485

  Fly    95 ------------AEKAGIKK-GDRILEV-NGVSVEGATHKQVVDLIKSGGDCLTLTVISVTQQEA 145
                        .|..||.: |.:|..| ...::|||                .|....|.:.|.
Mouse   486 LSLDDFRSTQKRGESFGISRIGSKIKGVFKSTTMEGA----------------VLPNYGVAEGED 534

  Fly   146 DRLEP----QEDQS-------------------GYSYIDY-----SDKRSLPISIPDYGI-VNRN 181
            |.:|.    .||.|                   ...|:|:     |:::.....||.:.| |.||
Mouse   535 DFIEEGIVVMEDDSPVEAVSTPNTPRNLAAWKISIPYVDFFEDPSSERKEKKERIPVFCIDVERN 599

  Fly   182 GERYIVFNIHMAGRQLCSRRYREFANLHSLLRKEFSGFNFP--KLPGK-------WPFQLSEQQL 237
            ..|.:.   |........|||.||..|.|.| .||.| .||  :||.|       :.|      |
Mouse   600 DRRAVG---HEPEHWSVYRRYLEFYVLESKL-TEFHG-TFPDAQLPSKRIIGPKNYEF------L 653

  Fly   238 DTRRRGLEQYLEKVCAVRVIAESDAVQDFLTDTEDDISASPVDIKVMLPDHEVSTVSVKKSSNAQ 302
            .::|...::||:|:.....::.|..:.|||:....:...    :..:|||  |:...:.||...:
Mouse   654 KSKREEFQEYLQKLVQHPELSNSQLLADFLSPNGGETQF----LDKILPD--VNLGKIIKSVPGK 712

  Fly   303 VVWE 306
            ::.|
Mouse   713 LMKE 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx27	NP_727023.1	PDZ_signaling	46..138	CDD:238492	20/121 (17%)
		PX_SNX27	165..270	CDD:132796	34/114 (30%)
		UBQ	278..363	CDD:294102	7/29 (24%)
		FERM-like_C_SNX27	428..528	CDD:270146
Snx14	NP_001346887.2	PXA	130..299	CDD:308031
		RGS_SNX14	340..466	CDD:188677	8/44 (18%)
		PX_SNX14	564..686	CDD:132787	37/132 (28%)
		Nexin_C	807..911	CDD:337134
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1370
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030