DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Snx27 and Snx25

DIOPT Version :9

Sequence 1:	NP_727023.1	Gene:	Snx27 / 31493	FlyBaseID:	FBgn0052758	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001359271.1	Gene:	Snx25 / 102141	MGIID:	2142610	Length:	986	Species:	Mus musculus

Alignment Length:	309	Identity:	68/309 - (22%)
Similarity:	102/309 - (33%)	Gaps:	88/309 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ENHPLPTPTPASAVVTASSGGGGGGAVVMGVGVGVTTANGPRVVTIYKTETGFGFNVRGQVSEGG 70
            |....|....||......|||..|...|.|.. ||   :.|....:.|
Mouse   550 EEEEEPDAQLASEKDELGSGGEAGEEAVEGTS-GV---SDPASFAVIK----------------- 593

  Fly    71 QLRSINGELYAPLQHVSAVLENGAAEKAGIKK-GDRILEVNGVSVEGATHKQVVDLIKSGGDC-- 132
             ||.:|.:|....|.:|::......:|..|.| .|.||.:.........|     :.::...|
Mouse   594 -LRELNEKLEYKRQALSSIQNAPKPDKKIISKLKDEILLIEKECTALQLH-----MARTDWWCEN 652

  Fly   133 LTLTVISVTQQEADRLEPQEDQSGYSYIDYSDKRSLPISIPDYGIVNRNGER----YIVFNIHMA 193
            |.|...|:|..|                                :...|||:    ::..|:...
Mouse   653 LGLWRASITSAE--------------------------------VTEENGEQMPCYFVRVNLQEV 685

  Fly   194 G-----RQLCSRRYREFANLHSLLRKEFSGFNFPKLP--GKWPFQ-LSEQQLDTRRRGLEQYLEK 250
            |     .....||..||.|||..|.:........:||  .|.||: :..:.|...|..|..:|:.
Mouse   686 GGVETKNWTVPRRLSEFQNLHRKLSECVPSLKKVQLPSLSKLPFKSIDHKFLGKSRNQLNAFLQN 750

  Fly   251 VCAVRVIAESDAVQDFLTDTEDDISASPVDIKVMLPDHEVSTVSVKKSS 299
            :.:...:.:|:|:..||       |.||..:||:       .|..||:|
Mouse   751 LLSDERLFQSEALYAFL-------SPSPDYLKVI-------DVQGKKTS 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx27	NP_727023.1	PDZ_signaling	46..138	CDD:238492	18/94 (19%)
		PX_SNX27	165..270	CDD:132796	26/116 (22%)
		UBQ	278..363	CDD:294102	7/22 (32%)
		FERM-like_C_SNX27	428..528	CDD:270146
Snx25	NP_001359271.1	PXA	148..303	CDD:366970
		RGS	437..545	CDD:383028
		End3	<558..645	CDD:372297	25/113 (22%)
		PX_SNX25	648..770	CDD:132788	33/160 (21%)
		Nexin_C	847..950	CDD:370015
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1370
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030