DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33080 and MGAM

DIOPT Version :9

Sequence 1:	NP_788858.1	Gene:	CG33080 / 31491	FlyBaseID:	FBgn0053080	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_001352622.1	Gene:	MGAM / 8972	HGNCID:	7043	Length:	2753	Species:	Homo sapiens

Alignment Length:	926	Identity:	193/926 - (20%)
Similarity:	301/926 - (32%)	Gaps:	306/926 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 TSSLGTPATPDTPGTTA-----------PTTTANTPDKA----------INFANDD-----SDDE 167
            |...||..||| ||||.           |.||..||..|          ||...|.     :.|:
Human    51 TPDPGTTGTPD-PGTTGTTHARTTGPPDPGTTGTTPVSAECPVVNELERINCIPDQPPTKATCDQ 114

  Fly   168 FGNARRPVHRDRFRSRRRASIAPLPALRLNSKEMLASDFDSHS------LASNQASITSVNSLAS 226
            .|....|         :.|...|......|           ||      |.:..|..|:
Human   115 RGCCWNP---------QGAVSVPWCYYSKN-----------HSYHVEGNLVNTNAGFTA------ 153

  Fly   227 LLREKMQAFPQ-----------LIRKKKRETKDYKIKIFVIIMFFIIIFLIGYAYVAYHQQVLTR 280
                :::..|.           |:      |.:|                          |...|
Human   154 ----RLKNLPSSPVFGSNVDNVLL------TAEY--------------------------QTSNR 182

  Fly   281 SYFQKIKFNSHDRIFRILSHEDKEVISGQLGVTLGFDT----APFHCLEEQRRSDGSVCIEWNGV 341
            .:| |:...:::| |.: .||..:..||....:|.:..    .|| .::..|||:..|..: :.:
Human   183 FHF-KLTDQTNNR-FEV-PHEHVQSFSGNAAASLTYQVEISRQPF-SIKVTRRSNNRVLFD-SSI 242

  Fly   342 ARLHLNFEDKGVFRCYTLQWQALTPGLLPTDCYEL-------KRDNGLWFGGGVTKGQEWSLSYA 399
            .  .|.|.|         |:..|:..|..|:.|.|       .|.:..|        :.|.:  .
Human   243 G--PLLFAD---------QFLQLSTRLPSTNVYGLGEHVHQQYRHDMNW--------KTWPI--F 286

  Fly   400 NFDFAPYASGDSKIHQFGNGVKRYFINSIGVAMQVSEKTPLQLGVNRTENRFCLRAANDEFTFVN 464
            |.|..|.          |||...|...:..:.::  :.:.|..||      |.:.:...|..
Human   287 NRDTTPN----------GNGTNLYGAQTFFLCLE--DASGLSFGV------FLMNSNAMEVV--- 330

  Fly   465 HLTPLPQLDYRIC------------TTEDMRSLHM-------LMTQQSLWDGLKEQEFKVLHSLL 510
             |.|.|.:.||..            |.|.:...::       |.:..:|...|...|:..|.: :
Human   331 -LQPAPAITYRTIGGILDFYVFLGNTPEQVVQEYLELIGRPALPSYWALGFHLSRYEYGTLDN-M 393

  Fly   511 EEPVWRIPHTELPESLNESAICDYSESAIAMGLGHIVINEFWQENIGDFTVDKARFPTLKDTIDV 575
            .|.|.|....:||..:..:.| ||.:..                  .|||.|...|....:.::.
Human   394 REVVERNRAAQLPYDVQHADI-DYMDER------------------RDFTYDSVDFKGFPEFVNE 439

  Fly   576 LHRRGFKVVLTIQPFISTDSANFKDAVKRKLLIYERHSERSIPALTRYKSSSSAGVL-------- 632
            ||..|.|:|:.:.|.||.:|::.|....     |:|.|:..|..      :||.||.
Human   440 LHNNGQKLVIIVDPAISNNSSSSKPYGP-----YDRGSDMKIWV------NSSDGVTPLIGEVWP 493

  Fly   633 ------DITNNASVPWLLEKLQRLKEEYGVQSFYLDLGTGYNL--PHYYQC-RQTLDNPDTYARL 688
                  |.||.....|..::.:....:......::|:....|.  .....| ...|:||....|:
Human   494 GQTVFPDYTNPNCAVWWTKEFELFHNQVEFDGIWIDMNEVSNFVDGSVSGCSTNNLNNPPFTPRI 558

  Fly   689 FTASLEGAGL---------------------MAVSTA----SVVPKPPTFLSTPPA--------- 719
            ....|....|                     |||:||    :|.|...:|:.|...
Human   559 LDGYLFCKTLCMDAVQHWGKQYDIHNLYGYSMAVATAEAAKTVFPNKRSFILTRSTFAGSGKFAA 623

  Fly   720 ------NATWEGLRETLGAVLNYGVIGYPFVLPGVIGGDYLLQRPLSKMVSFYSLSQPPLPDPEL 778
                  .|||:.||.::..||.:.:.|.|.|.|.:.|               ::|..|    .||
Human   624 HWLGDNTATWDDLRWSIPGVLEFNLFGIPMVGPDICG---------------FALDTP----EEL 669

  Fly   779 FIRWLQLATFMPAMQFSHL----------PSEYRSD-LVTRVAQELKEVRQLIVIPLLKKYLNPS 832
            ..||:||..|.|   ||..          |:.:.:| |:...::....:|..: :|.|......:
Human   670 CRRWMQLGAFYP---FSRNHNGQGYKDQDPASFGADSLLLNSSRHYLNIRYTL-LPYLYTLFFRA 730

  Fly   833 MNEGLPLVRPLWMMDPHDPACLIVSDEFSVGEELIVAPILHANREEREVYLPQGVWKDGIDGSLR 897
            .:.|..:.|||......|.:...|..:|..|..|::.|:|....|:...|:|..||.|...||..
Human   731 HSRGDTVARPLLHEFYEDNSTWDVHQQFLWGPGLLITPVLDEGAEKVMAYVPDAVWYDYETGSQV 795

  Fly   898 KGSRWMHGYRVPKDKI 913
            :..:......:|.|||
Human   796 RWRKQKVEMELPGDKI 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33080	NP_788858.1	GH31_NET37	511..888	CDD:269878	97/444 (22%)
MGAM	NP_001352622.1	Trefoil	90..132	CDD:306572	8/50 (16%)
		NtCtMGAM_N	150..259	CDD:318956	27/166 (16%)
		GH31_N	252..368	CDD:270212	27/147 (18%)
		GH31_MGAM_SI_GAA	368..731	CDD:269888	88/416 (21%)
		PD	957..1000	CDD:197472
		NtCtMGAM_N	1014..1127	CDD:318956
		GH31_N	1113..1234	CDD:270212
		Glyco_hydro_31	1215..1717	CDD:307274
		PD	1853..1896	CDD:197472
		NtCtMGAM_N	1910..2023	CDD:318956
		GH31_N	2009..2130	CDD:270212
		Glyco_hydro_31	2111..2613	CDD:307274
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810