DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33080 and SI

DIOPT Version :9

Sequence 1:	NP_788858.1	Gene:	CG33080 / 31491	FlyBaseID:	FBgn0053080	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_001032.2	Gene:	SI / 6476	HGNCID:	10856	Length:	1827	Species:	Homo sapiens

Alignment Length:	919	Identity:	171/919 - (18%)
Similarity:	287/919 - (31%)	Gaps:	305/919 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 TPATPD------TPGTTAPTTTANTPDKAINFANDDSDDEFGNARRPVHRDRFRSRRRASIAPLP 192
            |||..:      ||.||..||..:...|..|..||           ||:
Human    35 TPAVDEISDSTSTPATTRVTTNPSDSGKCPNVLND-----------PVN---------------- 72

  Fly   193 ALRLNS-KEMLASD-----------------------FDSHSLASNQASITSV------------ 221
             :|:|. .|...::                       .|:|.......:.||:
Human    73 -VRINCIPEQFPTEGICAQRGCCWRPWNDSLIPWCFFVDNHGYNVQDMTTTSIGVEAKLNRIPSP 136

  Fly   222 ----NSLASLLREKMQAFPQLIRKKKRETKDYKIKIFVIIMFFIIIFLIGYAYVAYHQQVLTRSY 282
                |.:.|:|.......|...|.|..:..:.:                   |...||.|
Human   137 TLFGNDINSVLFTTQNQTPNRFRFKITDPNNRR-------------------YEVPHQYV----- 177

  Fly   283 FQKIKFNSHDRIFRILSHEDKEVISGQLGVTLGFDTA----PFHCLEEQRRSDGSVCIEWNGVAR 343
                                ||.....:..|| :|..    || .::..|:|:|....: ..:..
Human   178 --------------------KEFTGPTVSDTL-YDVKVAQNPF-SIQVIRKSNGKTLFD-TSIGP 219

  Fly   344 LHLNFEDKGVFRCYTLQWQALTPGLLPTD-CYELKRDNGLWFGGGVTKGQEWSLSYANF-----D 402
            |           .|:.|:..::. .||:| .|.:        |..|.|.....||:..:     |
Human   220 L-----------VYSDQYLQIST-RLPSDYIYGI--------GEQVHKRFRHDLSWKTWPIFTRD 264

  Fly   403 FAPYASGDSKIHQFGNGVKRYFINSIGVAMQVSEKTPLQLGVNRTENRFCLRAANDEFTFVNHLT 467
            ..|   ||:..:.:|:  :.:|       |.:.:.:....||       .|..:|....|:.
Human   265 QLP---GDNNNNLYGH--QTFF-------MCIEDTSGKSFGV-------FLMNSNAMEIFIQ--- 307

  Fly   468 PLPQLDYRIC----------------TTEDMRSLHMLMTQQSLWD---GLKEQEFKVLHSLLEEP 513
            |.|.:.||:.                ..:..:.|..|....:.|:   .|....:|.| .:::|.
Human   308 PTPIVTYRVTGGILDFYILLGDTPEQVVQQYQQLVGLPAMPAYWNLGFQLSRWNYKSL-DVVKEV 371

  Fly   514 VWRIPHTELPESLNESAICDYSESAIAMGLGHIVINEFWQENIGDFTVDKARFPTLKDTIDVLHR 578
            |.|.....:|.....:.| ||                  .|:..|||.|:..|..|...:..||.
Human   372 VRRNREAGIPFDTQVTDI-DY------------------MEDKKDFTYDQVAFNGLPQFVQDLHD 417

  Fly   579 RGFKVVLTIQPFIS-------TDSANFKDAVKRKLLIYERHSERSI-----PALTRYKSSSSAGV 631
            .|.|.|:.:.|.||       |..|.::....:.:.|.|......|     |.||.|.
Human   418 HGQKYVIILDPAISIGRRANGTTYATYERGNTQHVWINESDGSTPIIGEVWPGLTVYP------- 475

  Fly   632 LDITNNASVPWLLEKLQRLKEEYGVQSFYLDL------------GTGYNLPHY------------ 672
             |.||...:.|...:.....:|......::|:            |...|..:|
Human   476 -DFTNPNCIDWWANECSIFHQEVQYDGLWIDMNEVSSFIQGSTKGCNVNKLNYPPFTPDILDKLM 539

  Fly   673 YQCRQTLDNPDTYARLFTA-SLEGAGLMAVSTASVV----PKPPTFLSTPPA------------- 719
            |.....:|....:.:.:.. ||.|.. ||::|...|    |...:|:.|...
Human   540 YSKTICMDAVQNWGKQYDVHSLYGYS-MAIATEQAVQKVFPNKRSFILTRSTFAGSGRHAAHWLG 603

  Fly   720 --NATWEGLRETLGAVLNYGVIGYPFVLPGVIGGDYLLQRPLSKMVSFYSLSQPPLPDPELFIRW 782
              .|:||.:..::..:|.:.:.|.|     ::|.|         :..|.:.:     ..||..||
Human   604 DNTASWEQMEWSITGMLEFSLFGIP-----LVGAD---------ICGFVAET-----TEELCRRW 649

  Fly   783 LQLATFMPAMQ------FSHLPSEY--RSDLVTRVAQELKEVRQLIVIPLLKKYLNPSMNEGLPL 839
            :||..|.|..:      :.|....:  ::.|:.:.:::...:|..: :|.|......:...|..:
Human   650 MQLGAFYPFSRNHNSDGYEHQDPAFFGQNSLLVKSSRQYLTIRYTL-LPFLYTLFYKAHVFGETV 713

  Fly   840 VRPLWMMDPHDPACLIVSDEFSVGEELIVAPILHANREEREVYLPQGVWKDGIDGSLRKGSRWMH 904
            .||:......|....|...||..|..|::.|:|....:....|:|..:|.|...|:.|...:...
Human   714 ARPVLHEFYEDTNSWIEDTEFLWGPALLITPVLKQGADTVSAYIPDAIWYDYESGAKRPWRKQRV 778

  Fly   905 GYRVPKDKI 913
            ...:|.|||
Human   779 DMYLPADKI 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33080	NP_788858.1	GH31_NET37	511..888	CDD:269878	87/440 (20%)
SI	NP_001032.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..61		6/20 (30%)
		PD	70..112	CDD:197472	6/58 (10%)
		Isomaltase	110..1007		153/816 (19%)
		NtCtMGAM_N	125..234	CDD:293468	23/167 (14%)
		GH31_N	227..333	CDD:270212	25/136 (18%)
		Glyco_hydro_31	324..797	CDD:279404	101/513 (20%)
		GH31_MGAM_SI_GAA	343..707	CDD:269888	79/412 (19%)
		PD	935..980	CDD:197472
		NtCtMGAM_N	994..1107	CDD:293468
		Sucrase	1008..1827
		GH31_N	1100..1214	CDD:270212
		Glyco_hydro_31	1195..1691	CDD:279404
		GH31_MGAM_SI_GAA	1214..1601	CDD:269888
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810