DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33080 and MYORG

DIOPT Version :9

Sequence 1:	NP_788858.1	Gene:	CG33080 / 31491	FlyBaseID:	FBgn0053080	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_065753.2	Gene:	MYORG / 57462	HGNCID:	19918	Length:	714	Species:	Homo sapiens

Alignment Length:	758	Identity:	198/758 - (26%)
Similarity:	325/758 - (42%)	Gaps:	123/758 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 REKMQAFPQLIR----------------------------KKKRETKDYK--IKIFVIIMFFIII 263
            :||.||:|:..|                            .|.:.:||.|  :...|:.:..::.
Human     6 QEKSQAYPRRRRPGCYAYRQNPEAIAAAAMYTFLPDNFSPAKPKPSKDLKPLLGSAVLGLLLVLA 70

  Fly   264 FLIGYAYVAYHQQVLTRSYFQ---------KIKFNSHDRIFRILSHE---DKEVIS---GQLGVT 313
            .::.:.|.:...:...|...:         .|:....:::||:....   |.:..|   ..||.:
Human    71 AVVAWCYYSVSLRKAERLRAELLDLKAGGFSIRNQKGEQVFRLAFRSGALDLDSCSRDGALLGCS 135

  Fly   314 LGFDTAPFHCLEEQRRSDGSVCIEWNGVARLHLNFEDKGVFRCYTLQWQALTPGLLPTDCYELKR 378
            |..|..|.|...:..|                    .|....||.::|:...||........|..
Human   136 LTADGLPLHFFIQTVR--------------------PKDTVMCYRVRWEEAAPGRAVEHAMFLGD 180

  Fly   379 DNGLWFGGGVTKGQEWSLSY-ANFDFAPYASGD--SKIHQFGNGVKRYFINSIGVAMQVSEKTPL 440
            ....|:||...:.|.|.:.. ...:..|:.:.|  |....||..::||:::|...|::|::..|.
Human   181 AAAHWYGGAEMRTQHWPIRLDGQQEPQPFVTSDVYSSDAAFGGILERYWLSSRAAAIKVNDSVPF 245

  Fly   441 QLGVNRTENRFCLRAANDEFTFVNHLTP---------LPQLDYRICTTEDMRSLHMLMTQQSLWD 496
            .||.|.||....|:|.       .|.||         .|:|.||:|...|:.|:|..|.::..
Human   246 HLGWNSTERSLRLQAR-------YHDTPYKPPAGRAAAPELSYRVCVGSDVTSIHKYMVRRYF-- 301

  Fly   497 GLKEQEFKV-LHSLLEEPVW--------RIPHTELPESLNESAICDYSESAIAMGLGHIVINEFW 552
               .:..:| ......:|:|        .:...::.....:..:..::.|       |:.|::.:
Human   302 ---NKPSRVPAPEAFRDPIWSTWALYGRAVDQDKVLRFAQQIRLHHFNSS-------HLEIDDMY 356

  Fly   553 QENIGDFTVDKARFPTLKDTIDVLHRRGFKVVLTIQPFISTDSANFKDAVKRKLLIYERHSERSI 617
            ....|||..|:.:||...|....|...||:|.|.:.||::.:|:.|.:.|:|:|.:  |.....:
Human   357 TPAYGDFDFDEVKFPNASDMFRRLRDAGFRVTLWVHPFVNYNSSRFGEGVERELFV--REPTGRL 419

  Fly   618 PALTRYKSSSSAGVLDITNNASVPWLLEKLQRLKEEYGVQSFYLDLGTGYNLPHYYQCRQTLDNP 682
            |||.|:.:...| |||.|:..:..|....|:||:..|.|.||..|.|....||..:...:.|.:|
Human   420 PALVRWWNGIGA-VLDFTHPKARDWFQGHLRRLRSRYSVASFKFDAGEVSYLPRDFSTYRPLPDP 483

  Fly   683 DTYARLFT-ASLEGAGLMAVSTASVVPKPPTFLSTPPANATWE---GLRETLGAVLNYGVIGYPF 743
            ..::|.:| .:|....|..|...........|......::.|.   |||..:.|||...::||||
Human   484 SVWSRRYTEMALPFFSLAEVRVGYQSQNISCFFRLVDRDSVWGYDLGLRSLIPAVLTVSMLGYPF 548

  Fly   744 VLPGVIGGDYLLQRPLSKMVSFYSLSQPPLPDPELFIRWLQLATFMPAMQFSHLPSEYRSDLVTR 808
            :||.::||:.:.||.....|          |:.||:||||::|.||||||||..|..|.:::|.
Human   549 ILPDMVGGNAVPQRTAGGDV----------PERELYIRWLEVAAFMPAMQFSIPPWRYDAEVVA- 602

  Fly   809 VAQELKEVRQLIVIPLLKKYLNPSMNEGLPLVRPLWMMDPHDPACLIVSDEFSVGEELIVAPILH 873
            :||:...:|..:|.|||.:......:.|.|:|||||.:.|.|.....:..:|.:|:.|:|||:|.
Human   603 IAQKFAALRASLVAPLLLELAGEVTDTGDPIVRPLWWIAPGDETAHRIDSQFLIGDTLLVAPVLE 667

  Fly   874 ANREEREVYLPQGVWKDGIDGSLRKGSRWMHGYRVPKDKIAYF 916
            ..::||:||||.|.|:........|....:..|.|..|:||||
Human   668 PGKQERDVYLPAGKWRSYKGELFDKTPVLLTDYPVDLDEIAYF 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33080	NP_788858.1	GH31_NET37	511..888	CDD:269878	121/388 (31%)
MYORG	NP_065753.2	GH31_NET37	314..682	CDD:269878	121/388 (31%)
MYORG	NP_065753.2	Glyco_hydro_31	329..707	CDD:279404	124/398 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5596
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D238940at2759
OrthoFinder	1	1.000	-	-		FOG0004094
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103615
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.670