DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33080 and GANC

DIOPT Version :9

Sequence 1:	NP_788858.1	Gene:	CG33080 / 31491	FlyBaseID:	FBgn0053080	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_001380857.1	Gene:	GANC / 2595	HGNCID:	4139	Length:	914	Species:	Homo sapiens

Alignment Length:	855	Identity:	162/855 - (18%)
Similarity:	279/855 - (32%)	Gaps:	253/855 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 RFRSRRRASIAPLPA-----------LRLNSKEMLASDFDSHSLASNQASITSVNSLASLLREKM 232
            ||:....||..||.|           |::|.:..|...|:...:      :||..|...|:....
Human    58 RFQIINEASKVPLLAEIYGIEGNIFRLKINEETPLKPRFEVPDV------LTSKPSTVRLISCSG 116

  Fly   233 QAFPQLIRKKKRETK------DYKIKIFVIIMFFIIIFLIGYAYVAYHQQVLTRSYFQKIKFNSH 291
            .....::...|.:.|      .:|:.:.......|.|..:|..|.. |.|:|.:   |:....:.
Human   117 DTGSLILADGKGDLKCHITANPFKVDLVSEEEVVISINSLGQLYFE-HLQILHK---QRAAKENE 177

  Fly   292 DRIFRILSHEDKEVISGQLGVTLGFDTAPFHCLEEQRRSDGSVCIEWNGVARLHLNFEDKGVFRC 356
            :......|.|::|    .||:.             :.:....|.|:.||.:.:.|:|...|....
Human   178 EETSVDTSQENQE----DLGLW-------------EEKFGKFVDIKANGPSSIGLDFSLHGFEHL 225

  Fly   357 YTLQWQALTPGLLPT---DCYELKRDNGLWFGGGVTKGQEWSLSYANFDFAPYASGDSK------ 412
            |.:...|.:..|..|   |.|.|                      .|.|...|...|..
Human   226 YGIPQHAESHQLKNTGDGDAYRL----------------------YNLDVYGYQIYDKMGIYGSV 268

  Fly   413 ----IHQFGNGVKRYFINSIGVAMQVS-----EKTPLQLGV--------NRTENRFCLRAA---- 456
                .|:.|..:..:::|:....::::     |.|..|:|.        :||...:...:.
Human   269 PYLLAHKLGRTIGIFWLNASETLVEINTEPAVEYTLTQMGPVAAKQKVRSRTHVHWMSESGIIDV 333

  Fly   457 --------NDEFTFVNHLTPLPQLDYRICTTEDMRSLHMLMTQQSLWDGLKEQEFKVL------H 507
                    :|.|...:|||          .|:.|..|..|...|..|:...||:.|.:      |
Human   334 FLLTGPTPSDVFKQYSHLT----------GTQAMPPLFSLGYHQCRWNYEDEQDVKAVDAGFDEH 388

  Fly   508 SLLEEPVW-RIPHTELPESLNESAICDYSESAIAMGLGHIVINEFWQENIGDFTVDKARFPTLKD 571
            .:..:.:| .|.|||                    |..:             ||.||.|||..|.
Human   389 DIPYDAMWLDIEHTE--------------------GKRY-------------FTWDKNRFPNPKR 420

  Fly   572 TIDVLHRRGFKVVLTIQPFISTDSANFKDAVKRK---LLIYERHSER----SIPALTRYKS---- 625
            ..::|..:..|:|:...|.|..| .::...||.|   ..:..:..|.    ..|.|:.|..
Human   421 MQELLRSKKRKLVVISDPHIKID-PDYSVYVKAKDQGFFVKNQEGEDFEGVCWPGLSSYLDFTNP 484

  Fly   626 ---------------SSSAGVLDITNNASVPWLL----EKLQR---------LKEEYGVQSFYLD 662
                           ..|..:|.:.|:.:.|.:.    :.:|:         .:|.:.:..||..
Human   485 KVREWYSSLFAFPVYQGSTDILFLWNDMNEPSVFRGPEQTMQKNAIHHGNWEHRELHNIYGFYHQ 549

  Fly   663 LGTGYNLPHYYQCRQTLDNPDTYARLFTASLEGAGLMAVSTASVVPKPPTFLSTPPANATWEGLR 727
            :.|...|   .:..:..:.|....|.|.|..:..|  ||.|..             ..|.|..|:
Human   550 MATAEGL---IKRSKGKERPFVLTRSFFAGSQKYG--AVWTGD-------------NTAEWSNLK 596

  Fly   728 ETLGAVLNYGVIGYPFV---LPGVIGGDYLLQRPLSKMVSFYSLSQPPLPDPELFIRWLQLATFM 789
            .::..:|...:.|..|.   :.|.||.                      |:.||.:||.|...:.
Human   597 ISIPMLLTLSITGISFCGADIGGFIGN----------------------PETELLVRWYQAGAYQ 639

  Fly   790 PAMQFSHLPSEYRSDLVTRVAQELKEVRQLI-----VIPLLKKYLNPSMNEGLPLVRPLWMMDPH 849
            |..:.....:..|.:......:..:.:|:.|     ::|........:.....|::||||:..|.
Human   640 PFFRGHATMNTKRREPWLFGEEHTRLIREAIRERYGLLPYWYSLFYHAHVASQPVMRPLWVEFPD 704

  Fly   850 DPACLIVSDEFSVGEELIVAPILHANREEREVYLP--QGVWKDGIDGSLRKGSRWMHG--YRVP- 909
            :.....:.||:.:|..|:|.|:........:|:||  ..||.|     .:..:.|..|  .::|
Human   705 ELKTFDMEDEYMLGSALLVHPVTEPKATTVDVFLPGSNEVWYD-----YKTFAHWEGGCTVKIPV 764

  Fly   910 -KDKIAYFRK 918
             .|.|..|::
Human   765 ALDTIPVFQR 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33080	NP_788858.1	GH31_NET37	511..888	CDD:269878	80/426 (19%)
GANC	NP_001380857.1	GH31_N	213..353	CDD:270212	28/171 (16%)
GANC	NP_001380857.1	GH31_GANC_GANAB_alpha	353..820	CDD:269889	99/501 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810