DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33080 and aagr-4

DIOPT Version :9

Sequence 1:	NP_788858.1	Gene:	CG33080 / 31491	FlyBaseID:	FBgn0053080	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	NP_508105.2	Gene:	aagr-4 / 180400	WormBaseID:	WBGene00018682	Length:	903	Species:	Caenorhabditis elegans

Alignment Length:	956	Identity:	190/956 - (19%)
Similarity:	309/956 - (32%)	Gaps:	345/956 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LLGAMPRKQSLSERRNVDLPHLKMVNEK---EPESATPSP---EAFAPGLRRNSISMPSGINA-- 101
            |:||:..         ||..:.|...:.   :...|..||   |.....::.|.    :|::|
Worm    10 LIGALDA---------VDRQNFKTCEQSGFCKRHRAVTSPTGYEVVGDSVKTNE----TGLHALI 61

  Fly   102 --------LDLEALR--------------LRHQMQPQDALHEEIIADDATSSLGTPATPDTPGTT 144
                    |.:.||:              ||.:.||.:||.:...|......:...||    .|.
Worm    62 KNKDTTLRLSIVALKDSTVRVVIDENDGALRKRYQPLEALVDREPAQQKVKKIKEEAT----ATK 122

  Fly   145 APTTTAN------TPDKAINFANDDSDDEFGNARRPVHRDRFRSRRRASIAPLPALRLNSKEMLA 203
            ..||..|      .|.: |:|...|......||:..:|.:.|:                 |::|.
Worm   123 VLTTDGNRIVLQHKPFR-IDFYVKDKIVSSINAKETLHFEAFK-----------------KKVLL 169

  Fly   204 SDFDSHSLASNQASITSVNSLASLLREKMQAFPQLIRKKKRETKDY-KIKIFVIIMFFIIIFLIG 267
            ||                       |||  .|.:...|:.::||.: ...:.|.|.|.....:.|
Worm   170 SD-----------------------REK--GFWEETFKEIKDTKPHGSSSVGVDIAFVGAKHVFG 209

  Fly   268 YAYVAYHQQVL----TRSYFQKIKFNSHDRIFRILSHEDKE--VISGQLGVTLGFDTAPFHCLEE 326
               :..|.:..    ||:|.....:|     ..:..:|...  .:.|.:...:|.         .
Worm   210 ---IPEHAESYSLRDTRTYEPYRLYN-----LDVFEYETNSPMALYGSIPYLVGV---------H 257

  Fly   327 QRRSDGSVCIEWNGVARLHLNFEDKGVFRCYTLQWQALTPGLLPTDCYELKRDNGLWFGGGVTKG 391
            |:||.|::   |...|...::.|                    ||...:          ||::|
Worm   258 QKRSVGAL---WLNAAETWVDIE--------------------PTTADK----------GGLSK- 288

  Fly   392 QEWSLSYANFDFAPYASGDSKIHQFGNGVKRYFINS--IGVAMQVSEKTPLQLGVNRTENRFCLR 454
                         .....|:|..|......|::..|  |.|.:.:..:
Worm   289 -------------EVLDADTKPRQVPQHNARFYSESGLIDVFITLGPQ----------------- 323

  Fly   455 AANDEF---TFVNHLTPLP---QLDYRICTTEDMRSLHMLMTQQSLWDGLKEQEFK------VLH 507
             .||.|   ..:..:||||   .|.|                .||.|:...:::.|      |.|
Worm   324 -PNDIFRQLAALTGVTPLPPAFALGY----------------HQSRWNYKDQKDVKEVHDGFVKH 371

  Fly   508 SLLEEPVW-RIPHTELPESLNESAICDYSESAIAMGLGHIVINEFWQENIGDFTVDKARFPTLKD 571
            .:..:.:| .|.||                                 :|...||.||..|...:|
Worm   372 DIPLDVLWLDIEHT---------------------------------DNKAYFTFDKDAFGKPED 403

  Fly   572 TIDVLHRRGFKVVLTIQPFISTDSAN--FKDAVKRKLL-------IYERH--------------- 612
            .|..|..:..|:|..:.|.|..||..  :|:|.|.|.|       |||.:
Worm   404 MIKDLADKNRKLVTIVDPHIKKDSKYYIYKEAKKNKYLVKDAKDTIYEGNCWPGDSTYIDFINPK 468

  Fly   613 -----SERSIPALTRYKSSSSAGVLDITNNASVPWLLE----KLQRLKEEYGVQSFYLDLGTGYN 668
                 ||:.  |..:||.::..  :.|.|:.:.|.:..    .:.:..:.:| :..:.|:   :|
Worm   469 ARKWWSEQF--AFDKYKGTTKD--VHIWNDMNEPSVFNGPEITMHKDAKHHG-EFEHRDV---HN 525

  Fly   669 LPHYYQCRQTLD----------NPDTYARLFTASLEGAGLMAVSTASVVPKPPTFLSTPPANATW 723
            :..::|...|.:          .|...:|.|.|..:       .||:|        .|....|.|
Worm   526 VYGFHQHSSTFEGLKARSNNEVRPFVLSRSFFAGSQ-------RTAAV--------WTGDNKADW 575

  Fly   724 EGLRETLGAVLNYGVIGYPFVLPGV-IGGDYLLQRPLSKMVSFYSLSQPPLPDPELFIRWLQLAT 787
            ..|::::..:|:....|.|||  |. :||             |:.     .||.||.:||.|...
Worm   576 AHLKQSIPMLLSLSTAGLPFV--GADVGG-------------FFG-----NPDEELLVRWYQAGA 620

  Fly   788 FMPAMQ-FSHLPSEYR-----SDLVTRVAQELKEVRQLIVIPLLKKYLNPSMNEGLPLVRPLWMM 846
            |.|..: .||..::.|     :|..|...:...:.|... :|............|.|::||.||.
Worm   621 FQPFFRGHSHQDTKRREPWLFADNTTEAIRNAIKTRYAF-LPYWYTLFYEHAKTGKPVMRPFWME 684

  Fly   847 DPHDPACLIVSDEFSVGEELIVAPILHANREEREVYLP--QGVWKD 890
            ...|........::.||..|:|.|:|....:|..:|||  :.||.|
Worm   685 FIEDEPSWDEDRQWMVGNGLLVKPVLEEKVKELSIYLPGKRQVWYD 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33080	NP_788858.1	GH31_NET37	511..888	CDD:269878	93/429 (22%)
aagr-4	NP_508105.2	DUF4968	61..146	CDD:379828	19/89 (21%)
		GH31_N	197..336	CDD:270212	34/220 (15%)
		GH31_GANC_GANAB_alpha	336..804	CDD:269889	108/488 (22%)
		DUF5110	779..852	CDD:379926
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810