DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33080 and ganc

DIOPT Version :9

Sequence 1:	NP_788858.1	Gene:	CG33080 / 31491	FlyBaseID:	FBgn0053080	Length:	925	Species:	Drosophila melanogaster
Sequence 2:	XP_021323148.1	Gene:	ganc / 100536353	ZFINID:	ZDB-GENE-130530-754	Length:	916	Species:	Danio rerio

Alignment Length:	759	Identity:	145/759 - (19%)
Similarity:	245/759 - (32%)	Gaps:	246/759 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 HEDKEVISGQLGVTLGFDTAPFHCLEEQRRSDGSVCIEWN-GVARLHLNFED-KGVFRCYTLQWQ 362
            ::..:|:.|:|         .:..|..:.:.:..||:.|. |..:|...|.. |....|...:..
Zfish    93 YQVSDVLVGEL---------RYEPLRVEWKKEDCVCLTWGLGQYQLLAFFSPFKLEISCAGEEIV 148

  Fly   363 ALTPGLLPTDCYELKRDNGLWFGGGVTKGQE-----WSLSYANFD----FAPYASG-DSKIHQFG 417
            .|.||  ...|:|..:|.........::|.|     |..::..|:    ..|.:.| |..:|.|.
Zfish   149 TLNPG--NKLCFETLQDPASRSSSNSSEGDENCCGLWKETFRQFEDIKANGPSSVGLDLSLHGFN 211

  Fly   418 N--GVKR-------------------------YFINS-------------------IGVAMQVSE 436
            :  ||..                         |.|||                   .||....|.
Zfish   212 HTYGVPEHADTLLLKDTSVSEAYRLYNLDVFGYEINSRLGLYGSVPLLLAHKPERTAGVFWLNSS 276

  Fly   437 KTPLQLGVNRTEN---------------RFCLRAANDEFT---FVNHLTPLP--------QLD-- 473
            :|.:.:..|..:|               |..:|..::..|   |: .|.|.|        ||.
Zfish   277 ETLVDVKYNTEQNEDEDEPPGKKSRISPRTDVRWISESGTIDCFI-LLGPTPAQVFSQYAQLTGK 340

  Fly   474 -----YRIC-------TTEDMRSLHMLMTQQSLWDGLKEQEFKV------LHSLLEEPVW-RIPH 519
                 |..|       :.:.:..|..|...|..|:...|.:.|.      ||.:..:.:| .|.|
Zfish   341 CRCRLYNGCARNRPLLSYQALPPLFSLGNHQCRWNYEDEADVKAVDAGFDLHGIPYDVIWLDIEH 405

  Fly   520 TELPESLNESAICDYSESAIAMGLGHIVINEFWQENIGDFTVDKARFPTLKDTIDVLHRRGFKVV 584
            |:                    |..:             ||.|..|||...:....|.::..|:|
Zfish   406 TD--------------------GKRY-------------FTWDSKRFPNPAELQHHLMKKKRKLV 437

  Fly   585 LTIQPFISTDS--ANFKDAVKRKLLIYERHS---ERSI-PALTRYKSSSSAGVLDITNNASVPWL 643
            :...|.|..|.  :.:.:|.|....:..|..   |.:. |..:.|        ||.:::.:..|.
Zfish   438 VISDPHIKMDPDWSIYCEAKKGGHFVKNREGFDFEGTCWPGESCY--------LDFSSSKTRLWY 494

  Fly   644 LEKLQRLKEEYGVQSFYL--DLGTG-------------------------YNLPHYYQCRQTL-- 679
            ..:....|.|...:|.::  |:...                         :||..:||...|.
Zfish   495 ARQFSLSKYEGSTESLFVWNDMNEPSVFNGPEQTMPKDALHHGGWEHRELHNLYGFYQHMATFEG 559

  Fly   680 --------DNPDTYARLFTASLEGAGLMAVSTASVVPKPPTFLSTPPANATWEGLRETLGAVLNY 736
                    :.|....|.|.|..:..|  |:.|...|             ||||.|:.::..:|:.
Zfish   560 LLTRSGGTERPFILTRSFFAGSQRLG--AIWTGDNV-------------ATWEYLKISIPMLLSL 609

  Fly   737 GVIGYPFVLPGVIGGDYLLQRPLSKMVSFYSLSQPPLPDPELFIRWLQLATFMP-------AMQF 794
            .:.|..|.  |...|.::..                 |||||.:||.|.....|       .|..
Zfish   610 SLTGIQFC--GADVGGFVQD-----------------PDPELLVRWYQAGALQPFFRAHSAKMTK 655

  Fly   795 SHLPSEYRSDLVTRVAQELKEVRQLIVIPLLKKYLNPSMNEGLPLVRPLWMMDPHDPACLIVSDE 859
            ...|..:..::.:.:...:::  :..::|......:.:....||.:||||:..|.|.:...|.::
Zfish   656 RREPWLFGEEVTSAIRSAVQD--RYCLLPYWYTLFHQAHTAALPPIRPLWVEFPKDTSTFAVENQ 718

  Fly   860 FSVGEELIVAPILHANREEREVYLP--QGVWKDGIDGSLRKGSR 901
            :.:|..|:|.|:......|.:|.||  ..:|.|.....:.||:|
Zfish   719 YMIGGALLVCPVTDPGVTEVKVLLPGSNELWYDTNTSEVHKGAR 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33080	NP_788858.1	GH31_NET37	511..888	CDD:269878	82/429 (19%)
ganc	XP_021323148.1	GH31_N	201..339	CDD:270212	25/138 (18%)
ganc	XP_021323148.1	GH31_GANC_GANAB_alpha	358..824	CDD:269889	95/482 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810