DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-B and ADAMTS1

DIOPT Version :10

Sequence 1:NP_572247.2 Gene:AdamTS-B / 31490 FlyBaseID:FBgn0029791 Length:1023 Species:Drosophila melanogaster
Sequence 2:NP_008919.3 Gene:ADAMTS1 / 9510 HGNCID:217 Length:967 Species:Homo sapiens


Alignment Length:1053 Identity:346/1053 - (32%)
Similarity:485/1053 - (46%) Gaps:195/1053 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 LLLHYWLVVVTQGGGVRPLYGLHSDELVAGEGQLVVPRRVHPDGAFMTHQLEYAHELDHRRHRQR 79
            |||...|:.|:...| ||     |:|    :.:||||            :||.|           
Human    37 LLLAAALLAVSDALG-RP-----SEE----DEELVVP------------ELERA----------- 68

  Fly    80 RSLNSEHDTQAADLHLLLPLANETLHLELMAHSYFLAPNLVVERHRRDLRTRSPLTTRHL-NCHF 143
                ..|.|....||..    ::.|.|||...|.||||...::...|...:.:||....| :|.:
Human    69 ----PGHGTTRLRLHAF----DQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFY 125

  Fly   144 HGKVRGQPATNVAISTCAGLVGHIRTAGNEYFIEP------------SKEHEPHPVNGHPHVVFQ 196
            .|.|.|.|::..|:|.|.|:.|.....|..|||:|            ..|..|.|:..|      
Human   126 SGTVNGDPSSAAALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFH------ 184

  Fly   197 RSSVKPKHSLRKRNKRKRGGKSGSGAEVSNCGT--REPRRRMETRLEWQARGKVKVQGGRQIRRH 259
                     |.:||  ::|...|:      ||.  .|||...:...|.:..|......|.|    
Human   185 ---------LLRRN--RQGDVGGT------CGVVDDEPRPTGKAETEDEDEGTEGEDEGAQ---- 228

  Fly   260 HHHHHHHHHKHKYRHHQQKISRVPHTKFKYETQFQTEPDHAEIPRRRRSISSPRHVETLIVADAT 324
                        :......:..|            .:|......|::|.:||.|:|||::|||.:
Human   229 ------------WSPQDPALQGV------------GQPTGTGSIRKKRFVSSHRYVETMLVADQS 269

  Fly   325 MSAFH-RDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRF 388
            |:.|| ..|..||||:.::.:.|||.|||.||:.:|||:|:.:.:|:...:  :|.||...|..|
Human   270 MAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPE--VTSNAALTLRNF 332

  Fly   389 CSWQHKLNKGSEKDPHHHDVAILITRKNIC-ANNCMTLGLANVGGMCKPKQSCSVNEDNGIMLSH 452
            |:||.:.|..|::|..|:|.|||.||:::| :..|.|||:|:||.:|.|.:||||.||:|:..:.
Human   333 CNWQKQHNPPSDRDAEHYDTAILFTRQDLCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAF 397

  Fly   453 TITHELGHNFGMFHDTAKIGCHP--RVGPIVHIMTPTFGADTLQVCWSNCSRKYITHFLDQGLGE 515
            |..|||||.|.|.||.|| .|..  .|....|:|............||.||...||.|||.|.||
Human   398 TTAHELGHVFNMPHDDAK-QCASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGE 461

  Fly   516 CL-DDPPTPLDEYNYTGELPGMRYNARGQCRLQFNLTTDSEVGACSAPHEFCSTLWCK-VNG--- 575
            || |.|..|:   ...|:|||..|:|..||  ||....||:  .|......||||||. .:|   
Human   462 CLMDKPQNPI---QLPGDLPGTSYDANRQC--QFTFGEDSK--HCPDAASTCSTLWCTGTSGGVL 519

  Fly   576 ECVTHMRPTAPGTLCGRNKWCQNGKCVRREEL----AAVNGGWGDWSEWSECSRSCGGGVSTQQR 636
            .|.|...|.|.||.||..|||.|||||.:.:.    ...:|.||.|..|.:|||:|||||....|
Human   520 VCQTKHFPWADGTSCGEGKWCINGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMR 584

  Fly   637 ECDNPVPANGGVFCIGERKRYKICRKRPCPAEE-PSFRAQQCA---RFDNVSY-QGATYKWLPFF 696
            |||||||.|||.:|.|:|.||:.|....||... .:||.:||.   .|...|: .|...:|:|.:
Human   585 ECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKY 649

  Fly   697 DKNNP---CKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQDDRC 758
            ...:|   |||.|..............|:|||||:..:.::|:.|.|.|.|||.|:||:.:.|:|
Human   650 AGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKC 714

  Fly   759 GVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRE-----LANSPHFLAIATGDG 818
            |||||:|..|:.:..:.|   :||.| |.:|:|||..|.:|.:::     ..|:..||||...||
Human   715 GVCGGNGSTCKKISGSVT---SAKPG-YHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADG 775

  Fly   819 GDRFYLNGDSLISMPGE--------FEIAGAESLYDRVDEQETITIPQPIQHSISLYAIVRGNES 875
              .:.||||..:|...:        ...:|:.:..:|:...      .|::..:::..:..||..
Human   776 --TYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSF------SPLKEPLTIQVLTVGNAL 832

  Fly   876 NAGIFYEF----------TLPALNVTAGRQFQWRLSNWTACSASCGGGVQHREPICQE-NGKALG 929
            ...|.|.:          .:|..:.       |.:..|..||.||..|.|.|...|:: ||:   
Human   833 RPKIKYTYFVKKKKESFNAIPTFSA-------WVIEEWGECSKSCELGWQRRLVECRDINGQ--- 887

  Fly   930 DTLPCWTHAKNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVCLDEHDV 994
               |....||..:|| .:|.|.|.||| .|..|.|..|..||.. |:     ::||:.||.....
Human   888 ---PASECAKEVKPA-STRPCADHPCP-QWQLGEWSSCSKTCGK-GY-----KKRSLKCLSHDGG 941

  Fly   995 VVADAECGHLQKP 1007
            |::...|..|:||
Human   942 VLSHESCDPLKKP 954

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-BNP_572247.2 Pep_M12B_propep 47..195 CDD:460254 43/160 (27%)
ZnMc_ADAMTS_like 314..518 CDD:239801 92/208 (44%)
ADAMTS_CR_2 534..602 CDD:465496 32/71 (45%)
TSP1 614..666 CDD:214559 29/51 (57%)
ADAMTS_CR_3 672..768 CDD:437068 38/102 (37%)
ADAMTS_spacer1 770..886 CDD:461796 30/138 (22%)
TSP1 901..956 CDD:214559 20/55 (36%)
TSP1_ADAMTS 959..1020 CDD:465950 16/49 (33%)
ADAMTS1NP_008919.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
Pep_M12B_propep 59..166 CDD:460254 39/137 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 192..250 13/91 (14%)
Cysteine switch. /evidence=ECO:0000250 196..203 3/12 (25%)
ZnMc_ADAMTS_like 258..463 CDD:239801 91/207 (44%)
ADAMTS_CR_2 478..546 CDD:465496 32/71 (45%)
TSP1 562..614 CDD:214559 29/51 (57%)
ADAMTS_CR_3 <658..724 CDD:437068 28/65 (43%)
Spacer 725..849 30/135 (22%)
ADAMTS_spacer1 726..842 CDD:461796 30/127 (24%)
TSP1_ADAMTS 858..909 CDD:465950 20/57 (35%)
TSP1_ADAMTS 912..>954 CDD:465950 14/47 (30%)
Blue background indicates that the domain is not in the aligned region.

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