Protein Alignment AdamTS-B and ADAMTSL1

DIOPT Version :10

• Sequence 1: NP_572247.2
• Gene: AdamTS-B / 31490
• FlyBaseID: FBgn0029791
• Length: 1023
• Species: Drosophila melanogaster
• Sequence 2: XP_011516365.1
• Gene: ADAMTSL1 / 92949
• HGNCID: 14632
• Length: 1828
• Species: Homo sapiens
• Alignment Length: 457
• Identity: 136/457 - (29%)
• Similarity: 203/457 - (44%)
• Gaps: 87/457 - (19%)

  Fly   598 NGKCVRREELAAVNGGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRK 662
            :.:..|.||  ..:|.|..|..||||||:||||.|...|.|      .....|.|...||:.|..
Human    88 SSRTARSEE--DRDGLWDAWGPWSECSRTCGGGASYSLRRC------LSSKSCEGRNIRYRTCSN 144

  Fly   663 RPCPAEEPSFRAQQCARFDNVSYQGATYKWLPFF-DKNNPCKLFCSDVDDTIIANWGATVLDGTP 726
            ..||.|...||||||:..::|.:.|..|:|||.. |.:|||.|.|.....|::......|||||.
Human   145 VDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTR 209

  Fly   727 CTLGTNNMCIDGICKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAA--KDGAYVEI 789
            |...:.:|||.|:|:.||||..:.|.|::|.||||.|.|..|:.||..|....:|  .|..   :
Human   210 CYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDT---V 271

  Fly   790 VTIPARARHI-LIRELANSPHFLAIATGDGGDRFYL--------NGDSLISMPGEFEIAGAESLY 845
            |.||..:||| |:.:              |.|..||        .|::.:|..|.|.:..:...:
Human   272 VAIPYGSRHIRLVLK--------------GPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDF 322

  Fly   846 DRVDEQETITIPQPIQHSISLYAIVRGNESNAG------IFYEFTLPALNVTAGRQFQWRLSNWT 904
            .:..::|.:.:..|:....    ||:...|.:.      |||:   |.::       :||.:::.
Human   323 QKFPDKEILRMAGPLTADF----IVKIRNSGSADSTVQFIFYQ---PIIH-------RWRETDFF 373

  Fly   905 ACSASCGGGVQHREPICQE--NGKALGDTLPCWTHAKNKRPARQSRGCGDQPCPA---------- 957
            .|||:||||.|.....|.:  :.:.:.|.. |..:.:|.:|..:.:.|...||||
Human   374 PCSATCGGGYQLTSAECYDLRSNRVVADQY-CHYYPENIKPKPKLQECNLDPCPASDGYKQIMPY 437

  Fly   958 -------HWWPGPWQFCPVTCRPVGFVAPPQRRRSVVCLDE----HDVVVADAECGHLQKPAEME 1011
                   .|...||..|..:|.  |.:    :.|:|.|::|    |...|.:.:|.:..|....:
Human   438 DLYHPLPRWEATPWTACSSSCG--GGI----QSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQ 496

  Fly  1012 PC 1013
            ||
Human   497 PC 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	47..195	CDD:460254
		ZnMc_ADAMTS_like	314..518	CDD:239801
		ADAMTS_CR_2	534..602	CDD:465496	0/3 (0%)
		TSP1	614..666	CDD:214559	20/51 (39%)
		ADAMTS_CR_3	672..768	CDD:437068	43/96 (45%)
		ADAMTS_spacer1	770..886	CDD:461796	28/132 (21%)
		TSP1	901..956	CDD:214559	15/56 (27%)
		TSP1_ADAMTS	959..1020	CDD:465950	16/59 (27%)
ADAMTSL1	XP_011516365.1	TSP1	102..148	CDD:214559	20/51 (39%)
		ADAMTS_CR_3	153..251	CDD:437068	43/97 (44%)
		ADAMTS_spacer1	270..362	CDD:461796	23/115 (20%)
		TSP1_ADAMTS	367..425	CDD:465950	16/58 (28%)
		TSP1_ADAMTS	446..503	CDD:465950	16/59 (27%)
		TSP1_ADAMTS	506..558	CDD:465950
		TSP1_ADAMTS	597..649	CDD:465950
		TSP1_ADAMTS	677..732	CDD:465950
		TSP1_ADAMTS	736..794	CDD:465950
		TSP1_ADAMTS	798..854	CDD:465950
		TSP1_ADAMTS	858..915	CDD:465950
		Ig	961..1015	CDD:409353
		Ig strand B	961..965	CDD:409353
		Ig strand C	974..978	CDD:409353
		Ig strand E	996..1000	CDD:409353
		Ig strand F	1010..1015	CDD:409353
		Ig	1253..1332	CDD:472250
		Ig strand B	1264..1268	CDD:409353
		Ig strand C	1277..1281	CDD:409353
		Ig strand E	1299..1303	CDD:409353
		Ig strand F	1313..1318	CDD:409353
		Ig strand G	1326..1329	CDD:409353
		Ig	1345..1434	CDD:472250
		Ig strand B	1370..1374	CDD:409353
		Ig strand C	1383..1387	CDD:409353
		Ig strand E	1402..1406	CDD:409353
		Ig strand F	1416..1421	CDD:409353
		Ig strand G	1429..1432	CDD:409353
		Ig	1475..1554	CDD:472250
		Ig strand B	1480..1484	CDD:409353
		Ig strand C	1493..1497	CDD:409353
		Ig strand E	1518..1522	CDD:409353
		Ig strand F	1532..1537	CDD:409353
		Ig strand G	1547..1550	CDD:409353
		TSP1_ADAMTS	1615..1673	CDD:465950
		TSP1_ADAMTS	1676..1732	CDD:465950
		TSP1_ADAMTS	1736..1791	CDD:465950
		PLAC	1796..1825	CDD:462560