DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and ADAMTS12

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_016865394.1	Gene:	ADAMTS12 / 81792	HGNCID:	14605	Length:	1631	Species:	Homo sapiens

Alignment Length:	1071	Identity:	367/1071 - (34%)
Similarity:	541/1071 - (50%)	Gaps:	178/1071 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTCS-RMWIRSRWLGLLLHYWLVVVTQ----GG---GVRPLYG------LHSDELVAG--EGQLV 49
            |.|: |.|:.:          |.||.|    |.   |.:|..|      ...:..:.|  |..:|
Human     1 MPCAQRSWLAN----------LSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVV 55

  Fly    50 VPRRVHPDGAFMTHQLEYAHELDHRRHRQRRSLNSEHDTQAADLHLLLPLANETLHLELMAHSYF 114
            .|.||...|.|:::.|.|    .....|::|.|:...|.    ::..:....:.|...|..:..|
Human    56 GPVRVDASGHFLSYGLHY----PITSSRRKRDLDGSEDW----VYYRISHEEKDLFFNLTVNQGF 112

  Fly   115 LAPNLVVER------HRRDLRTRSPLTTRHLNCHFHGKV--RGQPATNVAISTCAGLVGHIRTAG 171
            |:.:.::|:      |.:.:.:.:||      ||..|.|  :|......|:|.|.||.|..:...
Human   113 LSNSYIMEKRYGNLSHVKMMASSAPL------CHLSGTVLQQGTRVGTAALSACHGLTGFFQLPH 171

  Fly   172 NEYFIEPSKEHEPHPVNGHPHVVFQRSSVKPKHSLRKRNKRKRGGKSGSGAEVSNCGTREPRRRM 236
            .::||||.|:|.......|||:|::|..| |:                  .:...||.::.....
Human   172 GDFFIEPVKKHPLVEGGYHPHIVYRRQKV-PE------------------TKEPTCGLKDSVNIS 217

  Fly   237 ETRLEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQQKISRVPHTKFKYETQFQTEPDHAE 301
            :.:..|                          :.|:..|                         .
Human   218 QKQELW--------------------------REKWERH-------------------------N 231

  Fly   302 IPRR---RRSISSPRHVETLIVADATMSAFH--RDLNGYLLTIMNMVSALYKDPSIGNSIEIVVV 361
            :|.|   |||||..|.||||:|||..|..:|  .::..|:|||||||:.|:.:|||||:|.||||
Human   232 LPSRSLSRRSISKERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVV 296

  Fly   362 RIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKLNKGSEKDPHHHDVAILITRKNICA---NNCM 423
            |:|.|:|||..|:  :..:|:|.|..||.||..:|..|:.:|.|||||:|:|||:|||   ..|.
Human   297 RLILLEEEEQGLK--IVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCE 359

  Fly   424 TLGLANVGGMCKPKQSCSVNEDNGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPIVHIMTPTF 488
            ||||:::.|||:|.:||::|||:|:.|:.||.|||||:||:.||..:..|.| ||...:||:...
Human   360 TLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEP-VGRHPYIMSRQL 423

  Fly   489 GADTLQVCWSNCSRKYITHFLDQGLGECLDDPPTPLDEYNYTGEL--PGMRYNARGQCRLQF--N 549
            ..|...:.||.||.:|||.|||:|.|.||||.|   .:.....::  ||:.|:...||:||:  |
Human   424 QYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIP---KKKGLKSKVIAPGVIYDVHHQCQLQYGPN 485

  Fly   550 LTTDSEVGACSAPHEFCSTLWCKVNGECVTHMRPTAPGTLCGRNKWCQNGKCV---RREELAAVN 611
            .|      .|......|.||||.|.|.|.:.:...|.||.||..|||..|||:   ::.|  ::.
Human   486 AT------FCQEVENVCQTLWCSVKGFCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPE--SIP 542

  Fly   612 GGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQ 676
            ||||.||.||.|||:||.||.:.:|.|:||.|..||.:|.||||||::|...||.:|.|:||..|
Human   543 GGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFRQMQ 607

  Fly   677 CARFDNVSYQGATYKWLPFFDKNNPCKLFCSDVDDTIIANWGATVLDGTPCTLGTN--NMCIDGI 739
            |:.||.|.|:...|.|.|.|:..:||:|:|..:|..........|:|||||..|.|  |:||:||
Human   608 CSEFDTVPYKNELYHWFPIFNPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCINGI 672

  Fly   740 CKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGA-YVEIVTIPARARHILIRE 803
            ||.||||:.:||...:||||||.|.|..||.||:.    |..|:|: ||:|..||..||.|.:.|
Human   673 CKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKM----FKQKEGSGYVDIGLIPKGARDIRVME 733

  Fly   804 LANSPHFLAIATGDGGDRFYLNGDSLISMPGEFEIAGAESLYDRVDEQETITIPQPIQHSISLYA 868
            :..:.:||||.:.| .:::||||..:|...|.:::||....|||..:.|.:....|...|:.:..
Human   734 IEGAGNFLAIRSED-PEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDLEKLMATGPTNESVWIQL 797

  Fly   869 IVRGNESNAGIFYEFTLP---ALNVTAGRQFQWRLSNWTACSASCGGGVQHREPICQENGKALGD 930
            :.:  .:|.||.||:|:.   ..|....:.:.|:..:||.||.:||.|::.:...|.:.|:.:..
Human   798 LFQ--VTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVK 860

  Fly   931 TLPCWTHAKNKRPARQSRGCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVCLDEHDVV 995
            ...|   ....:|..:.:.|.::.||..||.|.|:.|..||.|.|     :::|:|:|:   ..:
Human   861 ATFC---DPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGPHG-----EKKRTVLCI---QTM 914

  Fly   996 VAD------AECGHLQKPAEMEPCESSLPIC 1020
            |:|      .:|.||.||..:..|...: :|
Human   915 VSDEQALPPTDCQHLLKPKTLLSCNRDI-LC 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	31/123 (25%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	104/208 (50%)
		Reprolysin	315..521	CDD:279729	107/210 (51%)
		ADAM_CR	<558..602	CDD:301627	19/43 (44%)
		TSP1	614..666	CDD:214559	29/51 (57%)
		ADAM_spacer1	773..886	CDD:283607	37/113 (33%)
		TSP1	901..956	CDD:214559	12/54 (22%)
ADAMTS12	XP_016865394.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	217	1.000	Domainoid score	I2674
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	636	1.000	Inparanoid score	I829
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	1	1.000	-	-		FOG0001196
OrthoInspector	1	1.000	-	-		otm40606
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5231
SonicParanoid	1	1.000	-	-		X2816
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.860