DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-B and Adamtsl5

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_011241828.1	Gene:	Adamtsl5 / 66548	MGIID:	1913798	Length:	548	Species:	Mus musculus

Alignment Length:	465	Identity:	137/465 - (29%)
Similarity:	191/465 - (41%)	Gaps:	106/465 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   612 GGWGDWSEWSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQ 676
            |.|..|..||.||.|||.|||.::|:|   |...|...|.|:...|::|:...||.....||..|
Mouse   110 GEWTPWGSWSRCSSSCGRGVSVRRRQC---VRLPGEELCWGDSHEYRVCQLPDCPPGTTPFRDLQ 171

  Fly   677 CARFDN--VSYQGATYKWLPFFDKNNPCKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGI 739
            |:.::.  |.....||:|:||....|.|.|.|.........::| .||||||||.||..:|:.|.
Mouse   172 CSLYNGHPVLDTQKTYQWVPFHGAPNVCDLNCLAEGHAFYHSFG-RVLDGTPCTPGTQGLCVAGR 235

  Fly   740 CKKVGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIREL 804
            |...|||.|:.|...:||||:|||:.|.|..|:..:.|  |.....:..:..||..||||.:.:
Mouse   236 CLSAGCDGILGSGTLEDRCGLCGGANDSCLFVQRVFRD--AGAFAGFWNVTLIPEGARHIRVAQ- 297

  Fly   805 ANSPHFLAIATGDGGDRFYLNGDSLISMPGEFEIAGAESLYDR-VDEQETITIPQPIQHSISLYA 868
             .|.:.||:.|  .|..:.||||.::|.||.:|.||...:|.| ...:||:....|....:.|..
Mouse   298 -RSHNHLALVT--RGGHYVLNGDGVLSPPGTYEAAGTRVVYTRSAGPEETLQATGPTSQELLLQV 359

  Fly   869 IVRGNESNAGIFYEFTLPALNVTAGRQFQWRLSNWTACSASCGGGVQHREPICQENGKALGDTLP 933
            ::|  |.|.|:.:||.||          :.|...:.|...:.|..::..:|...|...|....:|
Mouse   360 LLR--EPNPGVHFEFWLP----------RERYGPFQAQVQALGWPLRQPQPREVEPQPAETPVVP 412

  Fly   934 CWTHAKNKRPARQSR----GCGDQPCP-----AH------------------------------- 958
                  ...|||.:.    .||  |||     ||
Mouse   413 ------EAIPARVASLPPDPCG--PCPDSRGRAHRLLHYCGSDFVFQARVLGRHRQAQETRYEVR 469

  Fly   959 -----------------WWPGPWQFCPVTCRPVGFVAPPQRR-----RSVVCLD--EHDVVVADA 999
                             |.||   .||  |.|:.    |.|.     |.:|..|  :..:::..|
Mouse   470 VLLIYKSRTPLRTREYVWAPG---HCP--CPPLA----PHREYLLAARRLVSPDGTQDRLLLPHA 525

  Fly  1000 ECGHLQKPAE 1009
            ....|..|||
Mouse   526 GYARLWSPAE 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848
		ZnMc_ADAMTS_like	314..518	CDD:239801
		Reprolysin	315..521	CDD:279729
		ADAM_CR	<558..602	CDD:301627
		TSP1	614..666	CDD:214559	20/51 (39%)
		ADAM_spacer1	773..886	CDD:283607	35/113 (31%)
		TSP1	901..956	CDD:214559	12/58 (21%)
Adamtsl5	XP_011241828.1	TSP1	112..161	CDD:214559	20/51 (39%)
		ADAM_spacer1	270..375	CDD:368694	35/112 (31%)
		NTR_like	442..541	CDD:239600	17/103 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810