DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-B and Adamts4

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_076449.1	Gene:	Adamts4 / 66015	RGDID:	621242	Length:	851	Species:	Rattus norvegicus

Alignment Length:	926	Identity:	276/926 - (29%)
Similarity:	394/926 - (42%)	Gaps:	206/926 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RWLGLLLHYWLVVVTQGGGVRPLYGLHSDELVAGE---GQLVVPRRVHPDGAFMTHQLEYAHELD 72
            ||..|||...|:.:.......|    ..:|:|..|   |..::|      |:.:..:|.|.
  Rat    48 RWQQLLLLASLLPLAWSASPLP----REEEIVFPEKLNGSSIIP------GSGVPARLLYR---- 98

  Fly    73 HRRHRQRRSLNSEHDTQAADLHLLLPLANETLHLELMAHSYFLAPNLVVERHRRDLRTRSPLTTR 137
                                    ||...|.|.|||...     |.:.||          .||.:
  Rat    99 ------------------------LPAFGEILLLELEQD-----PGVQVE----------GLTVQ 124

  Fly   138 HL------------NCHFHGKVRGQPATNVAISTCAG-LVGHIRTAGNEYFIEPSKEHEPHPVNG 189
            :|            ..:..|.:.|.|.:..::....| |:|.::..|.|..::|.:....:...|
  Rat   125 YLGQAPEMLGGAEPGTYLTGTINGDPESVASLHWDRGALLGVLQYRGAELHLQPLEGGALNSAGG 189

  Fly   190 HPHVVFQRSSVKPKHSLRKRNKRKRGGKSGSGAEVSNCGTREPRRRMETRLEWQARGKVKVQGGR 254
                       ...|.||:::.....|      .:.|                     ||...|
  Rat   190 -----------PGAHILRRKSPASNRG------PICN---------------------VKAPSG- 215

  Fly   255 QIRRHHHHHHHHHHKHKYRHHQQKISRVPHTKFKYETQFQTEPDHAEIPRRRRSISSPRHVETLI 319
                                ....|||                      |.:|..|..|.||||:
  Rat   216 --------------------SPSPISR----------------------RNKRFASLSRFVETLV 238

  Fly   320 VADATMSAFH-RDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQK 383
            |||..|:||| ..|..||||:|...:..:|.|||.|.:.:||.|::.|...:...|:.  .:|.:
  Rat   239 VADDKMAAFHGAGLKHYLLTVMAAAAKAFKHPSIRNPVNLVVTRLVILGSGQEVPQVG--PSAAQ 301

  Fly   384 NLDRFCSWQHKLNKGSEKDPHHHDVAILITRKNIC-ANNCMTLGLANVGGMCKPKQSCSVNEDNG 447
            .|..||:||..||..::.||.|.|.|||.||:::| .:.|..||:|.||.:|.|.:||::.||:|
  Rat   302 TLRSFCTWQKGLNPPNDSDPDHFDTAILFTRQDLCGVSTCDALGMAGVGTVCDPARSCAIVEDDG 366

  Fly   448 IMLSHTITHELGHNFGMFHDTAK-------IGCHPRVGPIVHIMTPTFGADTLQVCWSNCSRKYI 505
            :..:.|..|||||.|.|.||.:|       .|...|     |:|.|.......:..||.||.::|
  Rat   367 LQSAFTAAHELGHVFNMLHDNSKPCANLNGQGSSSR-----HVMAPVMAHVDPEEPWSPCSARFI 426

  Fly   506 THFLDQGLGEC-LDDPPTPLDEYNYTGELPGMRYNARGQCRLQFNLTTDSEVGACSAPHEFCSTL 569
            |.|||.|.|.| ||.|..||   :.....||..|:|..||:|.|.  .||  ..|......|:.|
  Rat   427 TDFLDNGYGHCLLDKPEAPL---HLPVTFPGKDYDADRQCQLTFG--PDS--SHCPQLPPPCAAL 484

  Fly   570 WC--KVNGE--CVTHMRPTAPGTLCGRNKWCQNGKCVRREELAAVN----GGWGDWSEWSECSRS 626
            ||  .:||.  |.|...|.|.||.||..:.|..|:|:..::|...|    ||||.|..|.:|||:
  Rat   485 WCFGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHVDQLKDFNIPQAGGWGPWGPWGDCSRT 549

  Fly   627 CGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCP-AEEPSFRAQQCARFDN-----VSY 685
            |||||....|:|..|||.|||.:|.|.|..::.|..:.|| ....:||.:|||.:::     .|:
  Rat   550 CGGGVQFSSRDCTKPVPRNGGKYCEGRRTPFRSCNTKNCPHGSALTFREEQCAAYNHRTDLFKSF 614

  Fly   686 QGATYKWLPFFDKNNP---CKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGICKKVGCDW 747
            .| ...|:|.:....|   |||.|..............|.|||||:..::::|:.|.|...|||.
  Rat   615 PG-PMDWVPRYTGVAPRDQCKLTCQARALGYYYVLEPRVADGTPCSPDSSSVCVQGRCIHAGCDR 678

  Fly   748 IVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRELANS---PH 809
            |:.|:.:.|:|.||||:|..|    ...:..|......|.::|||||...|||:|:...|   ..
  Rat   679 IIGSKKKFDKCMVCGGNGSSC----SKQSGSFKKFRYGYSDVVTIPAGRTHILVRQQGGSGLKSI 739

  Fly   810 FLAIATGDGGDRFYLNGDSLISMPGEFEIA--GAESL-YD-RVDEQETITIPQPIQHSISLYAIV 870
            :||:...||.  :.|||:..: ||...::.  ||.|| |. |....||::...|:...::|..:|
  Rat   740 YLALKLADGS--YALNGEYTL-MPSSTDVVLPGAVSLRYSGRTAASETLSGHGPLAQPLTLQVLV 801

  Fly   871 RGNESNAGIFYEFTLP 886
            .||..|..:.|.|.:|
  Rat   802 AGNPQNVRLRYSFFVP 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	23/128 (18%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	86/213 (40%)
		Reprolysin	315..521	CDD:279729	88/215 (41%)
		ADAM_CR	<558..602	CDD:301627	17/47 (36%)
		TSP1	614..666	CDD:214559	24/51 (47%)
		ADAM_spacer1	773..886	CDD:283607	37/119 (31%)
		TSP1	901..956	CDD:214559
Adamts4	NP_076449.1	Pep_M12B_propep	92..195	CDD:279848	26/156 (17%)
		Reprolysin	232..442	CDD:279729	89/216 (41%)
		ZnMc_ADAMTS_like	232..439	CDD:239801	87/213 (41%)
		ADAM_CR	452..523	CDD:301627	28/74 (38%)
		TSP1	545..589	CDD:214559	20/43 (47%)
		ADAM_spacer1	701..816	CDD:283607	37/117 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720