DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and ADAMTS9

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	NP_891550.1	Gene:	ADAMTS9 / 56999	HGNCID:	13202	Length:	1935	Species:	Homo sapiens

Alignment Length:	1177	Identity:	340/1177 - (28%)
Similarity:	490/1177 - (41%)	Gaps:	316/1177 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 EGQLVVPRRVHPDGAFMTHQLEYAHELDHRRHRQRRSLNSEHD-----------TQAADLHLLLP 98
            |.::|.|.||:..|......:.:        .|.|||:||..|           :.::..|..|.
Human    47 EYEIVSPIRVNALGEPFPTNVHF--------KRTRRSINSATDPWPAFASSSSSSTSSQAHYRLS 103

  Fly    99 LANETLHLELMAHSYFLAPNLVVERHRRDLRTRSPLTTRHLN--------------CHFHGKVRG 149
            ...:.....|.|::.|:||          |.|.:.|.|..:|              |.:.|.|..
Human   104 AFGQQFLFNLTANAGFIAP----------LFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNT 158

  Fly   150 QPATNVAISTCAGLVGHIRTAGNEYFIEPSK---EHEPHPVNGHPHVVFQRSSV----------- 200
            .......||.|:|::|..|:...:|||||.:   |.|.......||::::||:.
Human   159 NSEHTAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTGRHAC 223

  Fly   201 -----KPKHSLRKRNKRKR--GGKSGSGAEVS--NCGTREPRRRMETRLEWQARGKVKVQGGRQI 256
                 |.:||..|:..|.|  |.:.....:|:  |.|       :.|. .:.|.|. |....|:.
Human   224 DTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSG-------LATE-AFSAYGN-KTDNTREK 279

  Fly   257 RRHHHHHHHHHHKHKYRHHQQKISRVPHTKFKYETQFQTEPDHAEIPRRRRSISSPRHVETLIVA 321
            |.|.                                           |.:|.:|.||.||.|:||
Human   280 RTHR-------------------------------------------RTKRFLSYPRFVEVLVVA 301

  Fly   322 DATMSAFH-RDLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNL 385
            |..|.::| .:|..|:||:|::|:::||||||||.|.||:|.:|.:..|:....::.  |||..|
Human   302 DNRMVSYHGENLQHYILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQDGPSISF--NAQTTL 364

  Fly   386 DRFCSWQHKLNKGSEKDPH--HHDVAILITRKNICA--NNCMTLGLANVGGMCKPKQSCSVNEDN 446
            ..||.|||     |:..|.  |||.|:|:||::||.  :.|.|||||.:|.:|.|.:|||::||:
Human   365 KNFCQWQH-----SKNSPGGIHHDTAVLLTRQDICRAHDKCDTLGLAELGTICDPYRSCSISEDS 424

  Fly   447 GIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPIVHIMTPTFGADTLQVCWSNCSRKYITHFLDQ 511
            |:..:.||.|||||.|.|.||.........|....|:|.||....|....||.|||||||.|||.
Human   425 GLSTAFTIAHELGHVFNMPHDDNNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDT 489

  Fly   512 GLGEC-LDDP---PTPLDEYNYTGELPGMRYNARGQCRLQFNLTTDSEVGACSAPHEF-CSTLWC 571
            |.||| |::|   |.||..     :|||:.||...||.|.|.      .|:...|:.. |..|||
Human   490 GYGECLLNEPESRPYPLPV-----QLPGILYNVNKQCELIFG------PGSQVCPYMMQCRRLWC 543

  Fly   572 -KVNG---ECVTHMRPTAPGTLCGRNKWCQNGKCVRRE-ELAAVNGGWGDWSEWSECSRSCGGGV 631
             .|||   .|.|...|.|.||.|...|.|:.|.||.:| ::...:|.||.||.:..|||:||||:
Human   544 NNVNGVHKGCRTQHTPWADGTECEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGI 608

  Fly   632 STQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCARFD----NVSYQGATYKW 692
            .|..|||:.|.|.|||.:|:|.|.::|.|...||..::..||.:|||.||    |::......:|
Human   609 KTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRW 673

  Fly   693 LPFFD---KNNPCKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQ 754
            :|.:.   ..:.|||||....:|........|:|||||...||::|:.|:|::.|||.:::|:.:
Human   674 VPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKAR 738

  Fly   755 DDRCGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRELA-----NSPHFLAIA 814
            .|:||||||....|:.|..|    |......|..:|.|||.|.:|.:|:.:     :..::||::
Human   739 RDKCGVCGGDNSSCKTVAGT----FNTVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALS 799

  Fly   815 TGDGGDRFYLNGDSLISMP--------GEFEIAGAESLYDRVDEQETITIPQPIQHSISLYAIVR 871
            :..|  .|.|||:.:::|.        ...|.:|:|:..:|::..:.      |:..:.|..:..
Human   800 SSKG--EFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDR------IEQELLLQVLSV 856

  Fly   872 GNESNAGIFYEFTLP-------------------------------------------------- 886
            |...|..:.|.|.:|
Human   857 GKLYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPCQGERKRKLVCTRESDQLTVSDQRCDRL 921

  Fly   887 -----------------------------------ALNVTAGRQFQ------------------- 897
                                               .|::...:..:
Human   922 PQPGHITEPCGTDCDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKP 986

  Fly   898 --------------WRLSNWTACSASCGGGVQHREPICQENGKALGDTLPCWTHAKNKRPARQSR 948
                          ||.|.||.||.||.||.|.|..||......:.|...| ||.:.....|
Human   987 SNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKC-THQEKVTIQR--- 1047

  Fly   949 GCGDQPCPAHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVCLDEHDVVVADAECGHLQKPAEMEPC 1013
             |.:.||| .|..|.|..|.|||      ....:.|.|.|....| .:.|..|....||..|:.|
Human  1048 -CSEFPCP-QWKSGDWSECLVTC------GKGHKHRQVWCQFGED-RLNDRMCDPETKPTSMQTC 1103

  Fly  1014 ESSLPIC 1020
            :.  |.|
Human  1104 QQ--PEC 1108

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	36/143 (25%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	96/209 (46%)
		Reprolysin	315..521	CDD:279729	98/214 (46%)
		ADAM_CR	<558..602	CDD:301627	18/48 (38%)
		TSP1	614..666	CDD:214559	26/51 (51%)
		ADAM_spacer1	773..886	CDD:283607	28/125 (22%)
		TSP1	901..956	CDD:214559	20/54 (37%)
ADAMTS9	NP_891550.1	Pep_M12B_propep	73..206	CDD:279848	36/142 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	192..242		11/49 (22%)
		Cysteine switch. /evidence=ECO:0000250	221..228		0/6 (0%)
		Reprolysin	293..499	CDD:279729	98/212 (46%)
		ZnMc_ADAMTS_like	293..496	CDD:239801	97/209 (46%)
		TSP1	591..642	CDD:214559	25/50 (50%)
		Spacer	753..877		30/135 (22%)
		ADAM_spacer1	753..871	CDD:283607	29/129 (22%)
		TSP1	1001..1054	CDD:214559	22/57 (39%)
		TSP1	1059..1103	CDD:214559	15/50 (30%)
		TSP1	1114..1166	CDD:214559
		TSP1	1186..1239	CDD:214559
		TSP1	1239..1296	CDD:214559
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1289..1330
		TSP1	1332..1384	CDD:214559
		TSP1	1386..1440	CDD:214559
		TSP1	1445..1499	CDD:214559
		TSP1	1504..1555	CDD:214559
		TSP1	1562..1613	CDD:214559
		TSP1	1615..1676	CDD:214559
		GON	1738..1934	CDD:285848
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720