DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-B and adamts8a

DIOPT Version :9

Sequence 1:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_021332165.1	Gene:	adamts8a / 569618	ZFINID:	ZDB-GENE-060526-202	Length:	940	Species:	Danio rerio

Alignment Length:	1014	Identity:	330/1014 - (32%)
Similarity:	477/1014 - (47%)	Gaps:	214/1014 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 RSLNSEHDTQAADLHLLLPLANETLHLELMAHSYFLAPNLVVERHR-RDLR-----TRSPLTTRH 138
            ||...:|...:|..||.|        |:|...|.|::|.|.|:|.: ::||     :||....|.
Zfish    43 RSEERQHFKLSAFGHLFL--------LDLSPDSKFVSPVLNVQRIKAKNLRSVLDASRSGGALRD 99

  Fly   139 L-----------NCHFHGKVRGQPATNVAISTCAGLVGHIRTAGNEYFIEP------SKEHEPHP 186
            .           :|.:.|.|..:..:.||:|.|.|:.|...|.|.||||.|      :.:|.|
Zfish   100 ATLYPDSGADLRDCFYTGTVNSEKESVVAVSLCHGIHGTFITQGVEYFIHPKASVQTTGKHFP-- 162

  Fly   187 VNGHPHVVFQRSSVKPKHSLRKRNKRKRGGKSGSGAEVSNCGTREPRRRMETRLEWQARGKVKVQ 251
               ..||:.:|:                         |||..|.
Zfish   163 ---QVHVIKRRA-------------------------VSNSRTA--------------------- 178

  Fly   252 GGRQIRRHHHHHHHHHHKHKYRHHQQKI-SRVPHTKFKYETQFQTEPDHAEIPRRRRSISSPRHV 315
                               .....|.|: |.|..:|..     .:|.:.:.:.|.:|.:|:.|::
Zfish   179 -------------------SLVFDQMKVDSLVKESKLN-----SSEDEDSNMRRAKRFVSAARYI 219

  Fly   316 ETLIVADATMSAFHRD-LNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQ 379
            |||:||||:|:.|:.| :..||||:|.|.:.::..||:.|::.:|||:::.:::||  :...|:.
Zfish   220 ETLVVADASMTRFYGDEIKHYLLTVMAMAAQVFVHPSLKNAVSLVVVKMVVVEDEE--VGPELSS 282

  Fly   380 NAQKNLDRFCSWQHKLNKGSEKDPHHHDVAILITRKNICA-NNCMTLGLANVGGMCKPKQSCSVN 443
            |....|..||.||...|.||::.|.|:|.|||.||::||. .:|.|||:|:||.||.||:||||.
Zfish   283 NGGVALRNFCMWQQLFNPGSQRHPEHYDTAILFTREDICGYKDCDTLGVADVGTMCDPKRSCSVI 347

  Fly   444 EDNGIMLSHTITHELGHNFGMFHDTAKIGCHPRVGPIV-HIMTPTFGADTLQVCWSNCSRKYITH 507
            ||||:..:.|::|||||...|.||.:| .|....|.:. |.|.|.|......:.||.||..|||.
Zfish   348 EDNGLQAAFTVSHELGHVLSMPHDDSK-NCEKWFGHLYGHTMAPFFVHLNKTLPWSPCSALYITE 411

  Fly   508 FLDQGLGECLDDPP---TPLDEYNYTGELPGMRYNARGQCRLQFNLTTDSEVGACS-AP-HEFCS 567
            |.|.|.|:||.|||   .||     ..||||..:....||:..|.    ::...|| || .:.|.
Zfish   412 FFDNGHGDCLLDPPEMTIPL-----AAELPGHTFGLDQQCQQAFG----NKYTHCSNAPADQTCV 467

  Fly   568 TLWCKVNG--ECVT-----HMRPTAPGTLCGRNKWCQNGKCVRR------EELAAVNGGWGDWSE 619
            .|||:..|  :|.|     |.   |.||.||.::.|:.|.|:..      |:...||||||:|..
Zfish   468 QLWCREEGKIQCTTRNGSLHW---ADGTPCGEDRRCREGLCLSSAMEEAGEQKVPVNGGWGEWGP 529

  Fly   620 WSECSRSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEE-PSFRAQQCARFDNV 683
            |..|||:|||||....|||.:|||.|||::|:|:|.:|:.|..:.||.:. .|||.:||.::::.
Zfish   530 WGPCSRTCGGGVEFSHRECTSPVPQNGGLYCVGQRVKYQSCNTQTCPEDHGKSFREEQCEKYNSD 594

  Fly   684 SY---QGATYKWLPFFDKNNP---CKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGICKK 742
            .|   :|...:|:|.:...:|   |||.|..........:.|.|:|||.|...|.::|:.|.|.|
Zfish   595 RYMDIKGNIKQWIPKYSGVSPRDRCKLVCRAKGSNEFKVFEAKVVDGTTCGPDTTSICVQGQCIK 659

  Fly   743 VGCDWIVDSEVQDDRCGVCGGSGDQCQPVRETYTDPFAAKDGAYVEIVTIPARARHILIRELANS 807
            .|||.::.|..:.|:|.||||.|..|:.:..:..   .|..| |::||||||.|.:|.|::.::.
Zfish   660 AGCDQVIGSNEKLDKCSVCGGDGTTCRKISGSLN---KATIG-YIDIVTIPAGATNIDIKQRSHR 720

  Fly   808 --PH---FLAIATGDGGDRFYLNGDSLISM-------PGE-FEIAGAESLYDRVDE----QETIT 855
              ||   :||:...||  .:.|||:..:||       ||. ...:|:.:..:|:..    ||.||
Zfish   721 GIPHDGNYLAVKAQDG--TYILNGNFSVSMAEQDVPVPGAMLRYSGSSTTLERLLSFHRLQEPIT 783

  Fly   856 IPQPIQHSISLYAIVRGNESNAGIFYEFTLP-----------------ALNVTAGRQFQWRLSNW 903
            |.         .....|:.|...|.|.|.||                 .::...|  |.|.|..|
Zfish   784 IQ---------LLSTAGDISPPRIKYTFFLPRDVPFSKPGTESRISTHVISPFGG--FDWVLGEW 837

  Fly   904 TACSASCGGGVQHREPICQENGKALGDTLPCWTHAKNKRPARQSRGCGDQPCPAHWWPGPWQFCP 968
            :.||.|||.|...|...|::...:|.     :....:.||| ..|.|||.|||. |..|||..|.
Zfish   838 SECSKSCGAGWSRRSVECRDGEGSLS-----YLCDADLRPA-DIRPCGDLPCPM-WQMGPWSACS 895

  Fly   969 VTCRPVGFVAPPQRRRSVVCLDEHDVVVADAECGHLQKP 1007
            .||      .|.:|.|:|||||....|:...:|...::|
Zfish   896 RTC------GPGERHRTVVCLDYAGKVLEPQKCNPDKRP 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	39/136 (29%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	91/206 (44%)
		Reprolysin	315..521	CDD:279729	93/208 (45%)
		ADAM_CR	<558..602	CDD:301627	19/52 (37%)
		TSP1	614..666	CDD:214559	26/51 (51%)
		ADAM_spacer1	773..886	CDD:283607	37/129 (29%)
		TSP1	901..956	CDD:214559	18/54 (33%)
adamts8a	XP_021332165.1	Pep_M12B_propep	37..167	CDD:307618	39/136 (29%)
		ZnMc_ADAMTS_like	217..422	CDD:239801	92/207 (44%)
		TSP1	533..576	CDD:214559	22/42 (52%)
		ADAM_spacer1	686..805	CDD:310520	37/133 (28%)
		TSP1	832..884	CDD:214559	20/57 (35%)
		TSP1	885..926	CDD:214559	17/47 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810